There are some other things in ?genetic-modifications.csv.

Gene candidates for germline genetic modification

Direct gene candidates

CD47 suppression

gobs of radiation resistance. prevent binding of thrombospondin to CD47 with a drug, inhibits NO production and somehow this prevents radiation damage and kills cancer cells. antisense CD47 RNA should do the trick permanently.

Add better summary here

Other radiation resistance: "What about radiation resistance? Here's a case in the literature where radiation resistance was improved 100,000-fold. 10-fold using e14-deletion. 50-fold using recA. 20-fold using yfjK. And 10-fold using dnaB. See Ecoli, Byrne et al, eLife 2014 ("Evolution of extreme resistance to ionizing radiation via genetic adaptation of DNA repair"). This only requires 4 mutations. There is a wide variation in natural organisms, but the only difference here is those 4 mutations."

Myostatin inhibition

There are a number of options here, but with germline modification, a muscle-specific knockout of ACVR2B or myostatin are good choices. Also follistatin overexpression in muscle.

PEPCK-C overexpression

In muscle, this allows greatly improved metabolism and endurance (see 'mighty mice'). Synergistic effect with myostatin inhibition is untested, but intriguing.

P53 overexpression

As the "guardian of the genome", p53 is missing in many cancers, and has been investigated as a gene therapy option for cancer. Introducing a separate copy, or copies of the gene from the wild-type could reduce the incidence of knockout mutations that normally lead to cancer.

milano allele

"Apolipoprotein A-1 Milano (also ETC-216, now MDCO-216) (ApoA-1 milano) is a naturally occurring mutated variant of the apolipoprotein A1 protein found in human HDL, the lipoprotein particle that carries cholesterol from tissues to the liver and is associated with protection against cardiovascular disease. ApoA1 Milano was first identified by Dr. Cesare Sirtori in Milan, who also demonstrated that its presence significantly reduced cardiovascular disease, even though it caused a reduction in HDL levels and an increase in triglyceride levels."

https://en.wikipedia.org/wiki/ApoA-1_Milano

Alpha-galactosidase expression

Humans are unsuited to digesting some types of branching carbohydrates, which then pass through the intestines and feed annoying bacteria. Not a huge priority, but with the increased metabolic demands from the muscle-enhancing therapies, it can't hurt.

CCR5 knockout

Provides resistance to HIV and plague. Increases risk from West Nile virus, but who gives a fuck about that.

Also see HCP5 (rs2395029), and CCL3L1.

See also rs333 for other details.

LRP5 gene (strong bones)

Those with the LRP5 gene have extra strong bones.

PCSK5 (lower coronary disease)

Those with the PCSK5 gene have 88 percent lower coronary disease. Also, PCSK9 (according to George Church) is also capable of lowering susceptibility to coronary disease.

APP (Alzheimer's)

"More than 50 different mutations in the APP gene can cause early-onset Alzheimer disease, which begins before age 65."

Amyloid precursor protein

FUT2 (norovirus / stomach flu resistance)

Those with double FUT2 are resistant to stomach flu.

rs601338

Allergy

  • rs2101521
  • rs9266772
  • rs7720838
  • rs10497813
  • rs9860547
  • rs6021270
  • rs17388568
  • rs1998359
  • rs17533090

ref

Lactase persistence (lactose tolerance)

http://snpedia.com/index.php/Rs4988235 http://snpedia.com/index.php/Rs4988235(C;C)

Also known as "C/T(-13910)", and located in the MCM6 gene but with influence on the lactase LCT gene, rs4988235 is one of two SNPs that is associated with the primary haplotype associated with hypolactasia, more commonly known as lactose intolerance in European Caucasian populations. [PMID 11788828], [PMID 15114531]

In these populations, the rs4988235(T) allele is both the more common allele and the one associated with lactase persistence; individuals who are rs4988235(C;C) are likely to be lactose intolerant. In populations of sub-Saharan Africans, though, the rs4988235(T) allele is so rare that it's unlikely to be predictive of lactase persistence, and other SNPs are predictive instead. [PMID 15106124, PMID 17159977]

Resistance to weight gain from high-fat diets (APOA5)

rs662799 increases risk of heart attack, but contributes towards preventing weight gain from high fat diets.

Hyperosmia (increased odor sensitivity)

rs1953558 - sensitivity to sweaty odor (isovaleric acid)

Smell

rs6591536 - detection of β-ionone (floral) fragrance

Pain sensitivity

rs6269

http://snpedia.com/index.php/Rs6269

Malaria resistance

DARC - rs2814778

HBB - i3003137

G6PD - rs1050828

Taste

sweetness - TAS1R2

umami - TAS1R1

sourness - PKD2L1

spiciness - TRPV1

signal - GNAT3, TRPM5, PLCB2

bitterness - TAS2R4, TAS2R5, TAS2R16, TAS2R8, TAS2R38, TAS2R48

Sprinting vs. endurance

ACTN3 - rs1815739

Eye color

green eye color - rs7495174

blue eye color - rs12913832

Hair color

https://www.snpedia.com/index.php/Redheads - MC1R SNPs like rs1805009(C;C), known as Asp294His or D294H; the most common variant associated with red hair and poor tanning ability in one study; rs1805007(T;T), known as Arg151Cys or R151C; associated with red hair, and in redheaded females, linked to being more responsive to the anesthetics pentazocine, nalbuphine, and butorphanol, often used by dentists; rs1805008(T;T), known as Arg160Trp or R160W; associated with red hair in an Irish population;

red hair SNPs from 23andme blog post:

  • rs34474212 C S83P
  • rs1805006 A D84E
  • rs11547464 A R142H
  • rs1110400 C I155T
  • i3002507 C D294H

MC1R rs1805005, known as Val60Leu or V60L, associated with light blond hair in one study (PMID 9302268.

Height

Height SNPs

Hearing

SNPs related to hearing loss

perfect pitch - rs3057 near 8q24

Modulated alcohol cravings

rs1799971

Baldness

rs6152

rs1160312

Cognitive

Hippocampus stuff:

Some loci associated with hippocampal volume found in genes related to apoptosis (HRK), development (WIF1), oxidative stress (MSR3B), ubiquitination (FBXW8), enzymes targeted by new diabetes medications (DPP4), and neuronal migration (ASTN2).

  • DPP4 - rs6741949 - G allele, smaller hippocampus vlume
  • ASTN2 - rs7852872 - C allele, smaller hippocampus volume
  • rs7294919, located on 12q24 between HRK and FBXW8, T allele, smaller hippocampus volume
  • rs17178006 - smaller hippocampus volume
  • rs6581612, between WIF1 and LEMD3, smaller hippocampus volume

optimization of ubiquitin metabolism in hippocampus ? The deubiquitinating enzyme USP46 regulates AMPA receptor ubiquitination and trafficking. Also influences glutamate receptors.

  • hippocampus volume (ref): rs11979341 (7q36.3) 200 kb upstream of SHH (sonic hedgehog) crucial for neural tube formation, rs7020341 (9q33.1) in ASTN2 (astrotactin 2), rs2268894 (2q24.2) in an intron of DPP4, rs2289881 (5q12.3) in an intron of MAST4 which modules microtubule scaffolding, rs7492919, rs17178006.

  • rs733722, near the choline acetyltransferase CHAT gene, -- controls whether galantamine can help fight mental decline in Alzheimer's disease

  • RIMS1 allele causing blindness but significantly increased verbal intelligence

Exceptional episodic memory:

  • rs9321334
  • MOXD1 (Monooxygenase, DBH-like 1) rs6902875 (when lacking an APOE ε4 allele); see also rs9321334 and rs4897574.

Educational attainment: rs9320913, rs11584700, rs4851266

cognitive performance: rs1487441, rs7923609, rs2721173 (Common genetic variants associated with cognitive performance identified using the proxy-phenotype method)

intelligence: rs10457441 rs1872841 rs10119 rs12204181 rs9375195 rs1487441 rs1906252 rs12202969 rs17522122 rs9388171 rs9401634 rs12206087 rs9375225

anti-depression: rs3787138, rs3787138, rs1044396, rs3787140

COMT rs4680 - higher frequency of complaint reporting? something about placebo effect? met/met more likely to respond to morphine than val/val allele.

Working memory

The polymorphisms rs1800497 and rs2283265 (also known as the Taq1a polymorphism) near the dopamine receptor 2 (DRD2) gene are associated with improvements during working memory training. (rs1800497(C;C) better avoidance of errors). However this polymorphism comes with serious tradeoffs: antisocial, borderline, dissocial, and avoidant personality disorders, addictive and impulsive behaviors such as binge eating, pathological gambling, and drug abuse. (more)

Other genes and polymorphisms associated with working memory improvements are listed on page 5 table 1: SLC6A3 (DAT1) rs27072 rs40184 rs3863145; DRD4 rs11246226 rs936465 rs7124601; PPP1R1B (DARPP32) rs3764352; MAOA rs6609257; ANKK1 rs1800497 (TAQ1A); DRD2 rs2283265; LMX1A rs4657412; BDNF rs6265; COMT rs4680

(in ADHD) CDH13 alleles associated with improved verbal working memory performance, see CDH13 intronic SNP rs11150556 and a nearby region (ref)

SNAP25

SNPs in the SNAP25 gene were initially linked to intelligence but have failed to replicate. While now suspect, the original work can be found here.

Memory enhancement in mice

from Genes and signaling pathways involved in memory enhancement in mutant mice:

Excitatory synaptic transmission:

MutantMemory phenotypesLTP phenotypes
NR2B (GluN2B) transgenicEnhanced in Morris water maze, contextual fear conditioning, object recognition test, non-match place to taskEnhanced CA1 LTP
Cdk5 conditional knockoutEnhanced in contextual fear conditioning, reversal learning in Morris water mazeEnhanced CA1 LTP
p25 transgenicEnhanced in Morris water maze, contextual fear conditioningEnhanced CA1 LTP
Kif17 transgenicEnhanced in Morris water maze, delay matching to place taskNot determined
ORL1 knockoutEnhanced in Morris water maze, contextual fear conditioning, PAEnhanced CA1 LTP
Hgf transgenicEnhanced in Morris water mazeNot determined
Cavβ3 knockoutEnhanced in Morris water mazeEnhanced CA1 LTP
Dao knockoutEnhanced in Morris water mazeEnhanced CA1 LTP

Presynaptic function:

MutantMemory phenotypesLTP phenotypes
H-ras transgenicEnhanced in Morris water maze, contextual fear conditioningEnhanced CA1, cortical LTP
Ncx2 knockoutEnhanced in Morris water maze, contextual fear conditioning, object recognition testEnhanced CA1 LTP
Cbl-b knockoutEnhanced in Morris water maze (remote memory)No change in CA1 LTP
Gap43 transgenicEnhanced in Morris water mazeEnhanced CA1 LTP

Inhibitory synaptic transmission:

MutantMemory phenotypesLTP phenotypes
GABAAR α4 (Gabra4) knockoutEnhanced in contextual fear conditioning, trace fear conditioningNot determined
Magl knockoutEnhanced in Morris water maze, object recognition testEnhanced CA1 LTP
Pkr (Eif2ak2) knockoutEnhanced in Morris water maze, contextual fear conditioning, auditory fear conditioningEnhanced CA1 LTP
GABAAR α5 (Gabra5) knockoutEnhanced in Morris water mazeTrend of enhanced CA1 LTP
Grpr knockoutEnhanced in contextual fear conditioning, auditory fear conditioningEnhanced amygdala LTP

Network activity:

MutantMemory phenotypesLTP phenotypes
Bec1 knockoutEnhanced in Morris water maze, y-mazeNo change in CA1 LTP; Impaired LTP in Tg
Kvβ1.1 knockoutEnhanced in Morris water maze (aged mice only)Enhanced CA1 LTP (aged mice only)
Hcn1 knockoutEnhanced in Morris water mazeEnhanced perforant path LTP

Transcriptional regulation and its upstream molecules:

MutantMemory phenotypesLTP phenotypes
CREB-Y134F transgenicEnhanced in Morris water maze, contextual fear conditioning, social recognition, "CD" (contextual discrimination?)Enhanced CA1 LTP
CREB-DIEDML transgenicEnhanced in contextual fear conditioning, social recognitionNot determined
eIF2αSS1A knock-inEnhanced in Morris water maze, contextual fear conditioning, auditory fear conditioningEnhanced CA1 LTP
Gcn2 knockoutEnhanced in Morris water maze, impaired in contextual fear conditioningEnhanced CA1 LTP
ATF4, C/EBP conditional inhibitionEnhanced in Morris water mazeEnhanced CA1 LTP
CamkIV transgenicEnhanced in contextual fear conditioningEnhanced CA1 LTP
Ac1 transgenicEnhanced in object recognition testEnhanced CA1 LTP
Ap oa1 transgenicEnhanced in contextual fear conditioning, object recognition testEnhanced CA1 LTP
Pde4d knockoutEnhanced in Morris water maze, radial arm maze, object recognition testNot determined but see reference
Pde8b knockoutEnhanced in Morris water maze, contextual fear conditioningNot determined
Calcineurin conditional inhibitionEnhanced in Morris water maze, auditory fear conditioning, object recognition testEnhanced CA1 LTP
PP1 conditional inhibitionEnhanced in Morris water maze, object recognition testEnhanced CA1 LTP

Translational regulation:

MutantMemory phenotypesLTP phenotypes
Paip2a knockoutEnhanced in Morris water maze, object location test, contextual fear conditioningEnhanced CA1 late phase LTP
Fkbp12 knockoutEnhanced in contextual fear conditioningEnhanced CA1 late phase LTP

Epigenetic regulation:

MutantMemory phenotypesLTP phenotypes
Hdac2 knockoutEnhanced in contextual fear conditioning, auditory fear conditioning, non-match place to taskEnhanced CA1 LTP

miRNA biogenesis:

MutantMemory phenotypesLTP phenotypes
Dicer1 knockoutEnhanced in Morris water maze, contextual fear conditioning, trace fear conditioningEnhanced CA1 LTP

Extracellular molecules:

MutantMemory phenotypesLTP phenotypes
Mmp9 transgenicEnhanced in Morris water maze, object recognition testEnhanced CA1 LTP
tPA (Plat) transgenicEnhanced in Morris water mazeEnhanced CA1 LTP
HB-GAM (Ptn) transgenicEnhanced in Morris water mazeEnhanced CA1 LTP

Other manipulations:

MutantMemory phenotypesLTP phenotypes
Ncs-1 transgenicEnhanced in Morris water maze, object recognition testEnhanced perforant path LTP
Rgs14 knockoutEnhanced in Morris water maze (learning), object recognition testEnhanced CA2 LTP
5-HT3R transgenicEnhanced in contextual fear conditioningNot determined
Maoa knockoutEnhanced in contextual fear conditioning, auditory fear conditioningNot determined
Hdc knockoutEnhanced in Morris water maze, contextual fear conditioning, auditory fear conditioningEnhanced CA1 LTP
Def45 knockoutEnhanced in Morris water maze, object recognition testNot determined
EC-SOD transgenicEnhanced in Morris water maze, impaired contextual fear conditioningEnhanced CA1 LTP
S100b knockoutEnhanced in Morris water maze, contextual fear conditioningEnhanced CA1 LTP

Theoretical "heterozygote advantages" genes

The principle here is that diseases such as sickle cell or Tay-Sachs, among many others, persist in a population because having one 'good' and one 'bad' copy of the gene offers a significant advantage - in disease resistance, intelligence, etc.

While it would be nice to find a point mutation that would mimic the benefits of heterozygosity, the most straightforward option would be to give someone both variants of the gene, with ~50% expression of each.

Longevity

mutations in:

  • KLOTHO
  • FOXO3 and FOXO3A

and:

  • APOB rs1801703, rs12713450, rs12720854

  • TOMM40 rs2075650 (see ref)

  • APOC1 rs4420638
  • APOE rs429358

maybe:

  • PPARGC1A rs148144750
  • NRG1 rs62497784
  • RAD52 rs35278212
  • NCOR1 rs61753150
  • RAD51 rs191297852
  • ADCY5 rs61734561
  • HLA-DRB5 rs71549220

  • PMS2

  • GABRR3

  • Various frameshift indels in TET2 and DNMT3A, and high levels of granulocytes in blood. "Both TET2 and DNMT3A are factors [28,29] and are thought to silence hematopoietic stem cell self-renewal to permit efficient hematopoietic differentiation [30,31]. Therefore, loss of functionality in these genes is likely to underlie an enhanced self-renewal leading to the observed age-related myeloid lineage bias. This skewing towards the myeloid lineage is assumed to have adverse effects on immune functionality in normal healthy individuals, but in the oldest old the increase of the myeloid compartment might be compensative for the age-related decrease in naive T-cells, known as immuno-senescence. Hence on condition that the enhanced self-renewal, instigated by somatic disruptive mutations in TET2 and DNMT3A, leads to increased levels of competent immune cells, be it of the myeloid lineage though, might partly compensate for the age-related loss of immuno-capacity of the lymphoid compartment." (from "Germ line and somatic characteristics of the long-lived genome")

Maybe also mutations in:

  • OBFC1 (telomere maintenance), rs77987791 rs77987791 rs7925084
  • GSK3B (healthy aging index)
  • NOTCH1 (diastolic blood pressure)
  • TP53 (serum HDL)
  • CTEP
  • ZNF562

... see "Candidate gene resequencing to identify rare, pedigree-specific variants influencing healthy aging phenotypes in the long life family study".

cognitive aging: "Genetic variants near MLST8 and DHX57 affect the epigenetic age of the cerebellum" -- MLST8, DHX57 -- see rs6723868 and "surrounding 25 SNPs"; and rs30986 -- "Within 20 kb of rs30986 are six genes: MLST8, PGP, E4F1, ECI1, DNASE1L2, and BRICD5"... and rs26840, rs27709, rs27648.

cognitive aging: TMEM106B and GRN alleles (ref)

skin aging: MC1R alleles have been found to add/subtract 2 years from one's youthful appearance. See rs34265416, rs4785704, rs34714188, rs12924124, rs35026726, rs12931267, rs75570604, MERGED_DEL_2_86235, 16:89913406:D, rs1805007, rs112556696, etc. Also see CALN1 rs10259553 and CORO2A rs35480968. (MC1R V92M is also associated with Alzheimer's disease risk)

skin aging: "Genetic variants associated with skin aging in the Chinese Han population" -- "Our candidate study found a significant association between SNP rs2066853 in exon 10 of the aryl hydrocarbon receptor gene AHR and crow’s feet. In addition, we found a significant association between SNP rs10733310 in intron 5 of BNC2 and pigment spots on the arms, and between SNP rs11979919, 3 kb downstream of COL1A2, and laxity of eyelids. Our results identified genetic risk factors for signs of skin aging (pigmentation, wrinkles or laxity) in Han Chinese."

  • Speculative longevity improvements: slow metabolism; and whatever metformin is doing.

Other notes

Tetracycline response elements, i.e. tet-on and tet-off, can be used for transgenes where constant expression is undesirable. While a number of options for such inducible expression exist, the tet system is the most studied. It is left as an exercise to the reader to determine which genes would be suitable candidates [I will add some when I get around to it].

Puberty and sexual characteristics

MKRN3 H420Q precocious/early puberty

puberty timing, check near: MAPK3, PXMP3, VGLL3, ADCY3-POMC, LIN28B

height related -- rs4788196 near MAPK3, height-increasing allele correlates to decreased expression of MAPK3

finger length / finger digit ratio SNPs:

  • rs314277 LIN28B
  • rs7759968 LIN28B ??
  • rs2332175
  • rs4902759 upstream of SMOC1

rs193536 - might impact male genitals and TF binding

rs246185 near MKL2 on chromosome 16p13.12 might be associated with 2.1 weeks earlier menarche, arrests early puberty, also impacts male genital development

breast size: http://www.snpedia.com/index.php/Breast_size and ref - see rs7816345, rs4849887, rs17625845, rs12173570, rs7089814, rs12371778, rs62314947, rs7089814(C;C), rs4665972(C;C), rs4849887(C;C), rs2819348(T;T), rs17356907(A;A), rs34479159(T;T), rs10488023(A;A), rs61159171(C;C), rs61280460(A;T), rs4820792(C;C), rs7837045(A;C), rs17625845(T;T), rs1529102(C;T), rs7102705(A;G), rs7104745(A;A), rs12585963(A;A), rs62314947(C;T)

Anti-myopia

see http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1003299 "Sixteen of the novel associations are in or near genes implicated in eye development, neuronal development and signaling, the visual cycle of the retina, and general morphology: BMP3, BMP4, DLG2, DLX1, KCNMA1, KCNQ5, LAMA2, LRRC4C, PRSS56, RBFOX1, RDH5, RGR, SFRP1, TJP2, ZBTB38, and ZIC2".

Anti-acne

https://www.ebi.ac.uk/gwas/search?query=acne

Candidate genes for sports doping

This is lifted from this table.

Gene/product System/organ targets Gene product properties Physiologic response
ACE skeletal muscles peptidyl dipeptidase ACE-D is involved in fast twitch muscles.
ACTN3 skeletal muscles actin-binding proteins related to dystrophin Involved in fast-twitch muscles.
endorphins central and peripheral nervous system widely active peptides pain modulation
EPO hematopoietic system glycoprotein hormone Increases RBC mass and oxygen delivery.
HGH endocrine system 191-amino acid protein Increases muscle size, power, and recovery.
HIF hematologic and immune systems multisubunit protein Regulates transcription at hypoxia response elements.
IGF-1 endocrine/metabolic/skeletal muscle 70-amino acid protein Increases muscle size, power, and recovery by increasing regulator cells.
myostatin (MSTN) skeletal muscle 2-subunit protein Regulates skeletal muscle. Inhibition increases muscle size, power, and recovery.
PPAR-delta skeletal muscle and adipose tissue nuclear hormone receptor protein Promotes fat metabolism and increases number of slow twitch fibers.
VEGF vascular endothelium glyosylated disulfide-bonded homodimers Induces development of new blood vessels.

Abbreviations: ACE, angiotensin-converting enzyme; ACTN3, actinin binding protein 3; EPO, erythropoetin; HGH, human growth factor; HIF, hypoxia inducible factor; IGF-1, insulin-like growth factor; PPAR-delta, peroxisome proliferators-activated receptor (delta); VEGF, vascular endothelial growth factor.

Others

  • alpha-actin-3 for endurance and increased power in sprinters
  • myostatin and follistatin and muscle hypertrophy
  • erythropoietin for red blood cell production
  • insulin-like growth factor 1
  • "an increase in synthesis of monoamines could improve the mood of athletes"
  • preproenkephalin for pain reduction
  • glucagon-like peptide 1 to increase glucose in liver and reduce lactic acid buildups for athletes
  • endurance: ACE Alu I/D (rs4646994) (called ACE I); ACTN3 577X; PPARA rs4253778 G; PPARGC1A Gly482;
  • power/strength markers: ACE Alu I/D (rs4646994) (called ACE D); ACTN3 Arg577; AMPD1 Gln12; HIF1A 582Ser; MTHFR rs1801131 C; NOS3 rs2070744 T; PPARG 12Ala;
  • human tetrachromacy
  • rs17822931 - dry earwax, sweat production, body odor. "rs17822931(T;T) individuals were at least 5-fold less likely to use deodorant, consistent with them being "genotypically nonodorous"".

Sleep

4-5 hours of sleep/night, plus resistance to sleep deprivation -- see http://gnusha.org/logs/2016-11-25.log

"The transcriptional repressor DEC2 regulates sleep length in mammals" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2884988/ (hDEC2-P385R)

"A novel BHLHE41 variant is associated with short sleep and resistance to sleep deprivation in humans" https://go.aastweb.org/Resources/journalclub/journalcluboctober2014.pdf

"Resisting sleep deprivation by breaking the link between sleep and circadian rhythms" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4173912/

"TNFα G308A polymorphism is associated with resilience to sleep deprivation-induced psychomotor vigilance performance impairment in healthy young adults" https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4467999/

morning person / "morningness": rs12736689 near RGS16, rs9479402 near VIP, rs55694368 near PER2, rs35833281 near HCRTR2, rs11545787 near RASD1, rs11121022 near PER3, rs9565309 near FBXL3; others reported in GWAS of 89,283 individuals identifies genetic variants associated with self-reporting of being a morning person ..

George Church's wish list

  • LRP5 G171V/+, extra strong bones
  • MSTN -/-, lean muscles and low atherosclerosis
  • SCN9A -/-, insensitivity to pain
  • ABCC11 -/-, low odor production
  • CCR5 -/-, HIV resistance
  • FUT2 -/-, norovirus resistance
  • PCSK9 -/-, low coronary disease
  • APP A673T/+, low alzheimers
  • APOE E2/E2, low alzheimers (E2=R112C, R158C)
  • GHR,GH, -/-, low cancer
  • SLC30A8 -/+, low type-2 diabetes
  • IFIH1 E627X/+, low type-1 diabetes
  • TERT overproduction, low aging
  • CDKN2A overproduction, low cancer
  • TP53 overproduction, low cancer
  • GRIN2B overproduction, high learning and memory
  • PDE4B inhibition, low anxiety and high problem solving in mice

TODO

Microbiome

dental caries vaccine

wikipedia

a genetically modified strain of Streptococcus mutans called BCS3-L1, is incapable of producing lactic acid, which dissolves tooth enamel, and aggressively replaces native flora. In laboratory tests, rats who were given BCS3-L1 were conferred with a lifetime of protection against S. mutans. Dr. Jeffrey D. Hillman suggests that treatment with BCS3-L1 in humans could also provide a lifetime of protection, or, at worst, require occasional re-applications. He figures the treatment would be available in dentists' offices and "will probably cost less than $100.

paper: Genetically modified Streptococcus mutans for the prevention of dental caries

Cellular changes and molecular biology

https://twitter.com/AdamMarblestone/status/792803428774866944

From "GWAS catalog"

https://www.ebi.ac.uk/gwas

Authorship

Originally authored by yashgaroth on 2012-06-28. See http://gnusha.org/logs/2012-06-28.log for more context.