From: Robert Coyote (coyyote@hotmail.com)
Date: Sun Dec 23 2001 - 14:29:15 MST
Adrafinil in not Scheduled and Modafinil is
I have used Adrafinil a few times for alertness during long distance
driving, graveyard shifts, it not toxic with occasional use like many
NSAID's
----- Original Message -----
From: "James Rogers" <jamesr@best.com>
To: <extropians@extropy.org>
Sent: Saturday, December 22, 2001 8:14 PM
Subject: Re: Staying Awake Drug?
: On 12/22/01 6:59 PM, "Max More" <max@maxmore.com> wrote:
: >
: > I've used Adrafinil, which I believe is pretty much the same thing. I
: > really couldn't notice any effect. If there was one, it was minor.
:
:
: Adrafinil is the only other drug in the same class as Modafinil
("eugorics"
: I believe), and was actually a primitive version of Modafinil. Adrafinil
: was cheap, but showed substantial liver toxicity and was poorly targeted
in
: the brain. Modafinil refined the initial breakthrough that was Adrafinil,
: eliminating many of the undesirable side effects and more narrowly
targeting
: the desired effect.
:
: I believe these are both readily available in many parts of Europe, though
I
: could be mistaken. They ARE scheduled in the U.S., so possession without
a
: rather narrow prescription is a crime.
:
:
: >> In addition to its wakefulness-promoting effects and increased
locomotor
: >> activity in animals, in humans, PROVIGIL produces psychoactive and
: >> euphoric effects, alterations in mood, perception, and thinking, and
: >> feelings typical of other CNS stimulants.
: >
: > Unless Modafinil is much more effective than Adrafinil, this seems
unlikely
: > to me.
:
:
: One of the hallmarks of eugorics is that the effect is largely
unnoticeable.
: This has made them unpopular in the recreational drug world. Several
: western militaries have adopted modafinil, citing very good real world
: performance and a lot of evidence suggesting far fewer long-term
: consequences (e.g. brain damage) than the amphetamine type drugs
previously
: used. The basic operational subtlety from a military standpoint is that
: amphetamines prevent sleep, whereas eugorics eliminate the need to sleep.
: As I recall, one of the features that the military liked with modafinil
was
: that most people on it had the ability to sleep at will regardless of
where
: they were in their dosing cycle. This greatly aided in the use of
unnatural
: and irregular sleep schedules without significant reductions in
performance.
:
: This is all from memory, though, so I could be mistaken.
:
: -James Rogers
: jamesr@best.com
:
:
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