About the diyhpl.us wiki
The diyhpl.us wiki (diyhpluswiki) is a wiki for open source hardware, do-it-yourself biohacking and practical human enhancement engineering projects which could be called transhumanism. The engineering teams behind this wiki can be found in the hplusroadmap IRC channel (logs). Our projects are self-funded by the diyhpl.us group and community.
The domain name "diyhpl.us" comes from "do-it-yourself human enhancement" or "plus". The domain name "diyhpl.us" (diyhplus) hosts the diyhplus wiki (diyhpluswiki) which covers topics such as human enhancement, genetic engineering, germline genetic engineering, gene therapy, cell therapy, human enhancement, intelligence enhancement, open-source hardware, molecular nanotechnology, kinematic self-replicating machines, do-it-yourself biology, synthetic biology, kinematic self-replicating machines, molecular nanotechnology, evolutionary algorithms for applied molecular evolution, etc.
Most of this wiki is an attempt to summarize the interesting developments and techniques from over 15 years of hplusroadmap IRC chat logs which are publicly available logs.
Interesting pages
- Potential human enhancements via human embryo germline genetic engineering is the diyhpluswiki's long-running 15+ year living document of potential human embryo germline modifications. The proposed and documented human embryo engineering enhancements include upgrades for longevity, intelligence, learning, memory, sleep, disease resistance, future proofing, immune system upgrades, and many other speculative subjects. It's a combination of direct genetic engineering interventions (such as upregulation, overexpression, knock-in, knock-out, etc), genome-wide association studies (GWAS) mutational hints, human studies, familial studies, transgenic mice studies, transgenic rat studies, and other sources of knowledge. The goal is to provide a roadmap for embryo engineering and embryo technology development. At this point, the diyhplus human embryo engineering wish list is the largest list of potential human enhancements on the web.
Other pages:
- What is hplusroadmap?
- Proposed human embryo genetic upgrades
- gene editing - various gene therapy tools and mechanisms
- gene therapy - information about approaches for gene therapy
- cell therapy - information about approaches to cell therapy
- Human cloning and non-human cloning
- protein engineering - protein folding and protein engineering wish list
- nutrition - unbreaking human metabolism
- Methods for human brain uploading
- Human gigafactory plan - the human gigafactory is a plan for making more humans at scale using large-scale engineering to grow billions of new humans.
- Conference transcripts - mostly handwritten transcripts from bryan's adventures in live word-for-word notetaking at conferences, now mostly migrated to btctranscripts.com but on this wiki there is also substantial non-bitcoin related transcripts such as in the fields of synthetic biology, brain uploading, protein engineering, etc.
- various old DNA project ideas - what can you do with DNA synthesis?
- DIYbio FAQ - this is a basic FAQ on do-it-yourself biohacking
- DIYbio group list - an old list of do-it-yourself biology (DIYbio) community groups in different cities.
- a laser_etcher for microfluidics project (see cgit).
Index of pages
- DNA data storage
- DNA nanoscopy
- DNA sequencing
- DNA ticker tape
- ant routing
- artificial life
- artificial womb
- azobenzene
- bioprinting
- biosight
- bitcoin
- blastocyst complementation
- brain
- brain imaging
- brain uploading
- cad
- cell-specific expression
- cell-specific targeting
- cell therapy
- chatsummaries
- cloning
- cryonics
- diabetes
- distillation
- diybio
- dna
- expansion microscopy
- extra ovaries
- fda
- fisseq
- gene-editing
- gene-therapy
- gene editing
- gene therapy
- genetic-modifications
- genetic-modifications.csv
- goals.yaml.txt
- homecmos
- hplusroadmap
- human-gigafactory
- human-modifications.csv
- human brain reverse engineering
- images
- immune system
- in-vitro-fertilization
- in situ sequencing
- in vitro fertilization
- index
- information physics
- intelligence
- kanzure
- lineage tracing
- longevity
- mapseq
- mitochondria
- mitochondria longevity
- morphogenesis
- myostatin
- nanotech
- nerve graft
- neuroscience
- neurosurgery
- nootropics
- nutrition
- octopus
- optogenetic-axon-guidance
- optogenetics
- organoids
- polymerase
- projects
- protein-engineering
- protein engineering
- protein sequencing
- proteins
- reservoir computing
- scaffolding
- self-replicating machines
- senses
- sleep
- talk:diybio
- trans-tech.yaml.txt
- transcripts
- transhumanism
- users
- volitional control
- wikiicons
- wikis
- xenotransplantation
Editing this wiki
Submit a pull request on github: https://github.com/kanzure/diyhpluswiki
Register to edit here and see other commands. You can also clone this wiki with git and push changes back:
git clone git://diyhpl.us/diyhpluswiki.git
Note to push changes you must push with your registered account:
git push username@diyhpl.us:/srv/git/diyhpluswiki.git master
You can make this easier by updating the remotes:
git remote set-url origin username@diyhpl.us:/srv/git/diyhpluswiki.git
Now "git push" should work without debilitating complaint.
What is hplusroadmap?
hplusroadmap is a collaborative community of engineers, scientists, and makers working to transform transhumanist concepts into practical projects and open-source technology, with a focus on biological enhancement, longevity, intelligence, nanotechnology, space colonization, and other emerging technologies.
The #hplusroadmap IRC channel is a technology development and engineering group that focuses on projects such as:
- do-it-yourself biology, ?genetic engineering, gene therapy, biohacking, ?synthetic biology
- human embryo genetic engineering (ref), human cloning, non-human cloning, chimeras, hybrids, microchimerism, xenotransplantation, in vitro fertilization
- artificial womb, uterus (xeno)transplantation, ex vivo uterus, organ xenotransplantation
- DNA synthesis machine development
- brain emulation, human brain uploading, computational neuroscience, neuroanatomy, neurosurgery
- nootropics, smart drugs, intelligence enhancement, memory enhancement
- cryonics, biobanking
- molecular nanotechnology
- molecular biology, polymerase, fusion proteins, ?directed evolution, gene editing
- protein engineering, protein design, protein language models, protein diffusion, enzyme engineering
- nutrition, bodybuilding
- open-source hardware development
- ?space colonization, ?megastructure engineering, habitats, mining, communication, transportation
- ?self-replication, self-replicating machines, kinematic self-replicating machines, RepRap
- robots, mechanical automation, machining, electronics
- computer architecture, supercomputing, parallel computing, decentralized p2p protocols or distributed systems
- intelligence (both biological and artificial), superintelligence, ?biological superintelligence, in vitro neural tissue culture, biocomputing
- open-source software development, computer programming, non-computer programming, in materio computing
- life extension, anti-aging, longevity research
- transhumanism
- applied cryptography, zero-knowledge proofs, bitcoin technology development
Chat logs both recent and historical logs
All logs are stored at https://gnusha.org/logs/?C=M;O=D and are instantly updated after receiving new messages.
Connecting to IRC
The easiest way to join is to simply go to http://web.libera.chat/#hplusroadmap and click "Start".
Discord bridge: https://discord.gg/vFPzfaaeXv
Users who plan to contribute often are encouraged to seek out better IRC clients. The channel inhabitants seem to like irssi, HexChat, ChatZilla for Firefox, Textual for OS X, Pidgin, and a variety of bouncers and remote shells.
- download and run an IRC client
- /connect irc.libera.chat
- /join #hplusroadmap
The hplusroadmap chat is an active community with daily, weekly and monthly participants working on technology development.
Collaboration
We have a wide range of different projects, some that are open source technology engineering projects, and others that are private commercial ventures. We're open to collaboration in public on open source or other open projects and are always interested in meeting collaborators in the extended community.
Project funding and opportunities
There's some funding available for hplusroadmap projects. Are you interested in making human clones? Do you want to work on molecular nanotechnology? Bring us your projects and let's talk. If we're not the right fit for funding your human enhancement project, then we likely know someone else who would be a better match.
History
The hplusroadmap IRC channel was started in 2008 to focus on a roadmap for transhumanist technology development, do-it-yourself biohacking and turning near-future ideas into practical engineering projects.
The channel was hosted on Freenode until 2021-05-19, when a hostile takeover of the network led us to move to libera.chat.
hplusroadmap originally started as a mailing list in 2007. The chat group was founded and is primarily administered by Bryan Bishop (kanzure).
Arc of history and S-N ratio
hplusroadmap has an unusually high signal-to-noise ratio. For example, the hplusroadmap community was extremely early to bitcoin showing word of bitcoin in the hplusroadmap logs on January 10, 2009 just 2 days after Satoshi Nakamoto's second or third announcement of the creation of bitcoin on the p2pfoundation mailing list. Thanks are also owed to Eugen Leitl for the nudge at that time.
Certain participants choose to remain anonymous such as investors, university professors, entrepreneurs, programmers, and various hackers. For a while we were adjacent to, though not affiliated with, the Jiankui He genetically modified human births controversy; and at different times adjacent to the Human Genome Synthesis Project (GP-write), coordination around DNA synthesis screening, the bitcoin project, and other things I'm probably forgetting.
It is hard to describe what this thing is. There is a wide variety of highly unusual and unlikely content in the logs. The Internet has a sort of "weirding way" about it, dunno what else to say except that there's some level of intentional or at least indirectly intentioned illegibility here. There's also noise and spam from time to time but we try to not have that. Buyer beware.
Naming of hplusroadmap
Why is the hplusroadmap engineering group called "hplusroadmap"? Originally there was a mailman-style public mailing list for discussion around a "Transhumanist Technical Roadmap" back in 2007 on Bryan Bishop (kanzure)'s previous wiki. The name "hplusroadmap" comes from "hplus" (h+) for "human plus" (which at one point was a term used to reference transhumanist projects) and "roadmap" for "roadmap".
Rules
- no philosophy (violators that are bad at philosophy will be harshly judged)