From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Thu Dec 23 1999 - 13:23:23 MST
Authors
Anisimov VN. Osipova GYu.
Institution
Laboratory of Experimental Tumors, N.N. Petrov Research Institute of
Oncology, St. Petersburg, Russia.
Title
Life span reduction and
carcinogenesis in the progeny of rats exposed neonatally to
5-bromo-2'-deoxyuridine.
Source
Mutation Research. 295(3):113-23, 1993 Aug.
Abstract
Outbred LIO rats were given subcutaneous injections (3.2 mg) of a synthetic
analogue of thymidine, 5-bromo-2'-deoxyuridine (BrdUrd) on days 1, 3, 7 and
21 postnatally. At 3 months, the treated males and females were mated to
generate F1 progeny. The mean life span
decreased by 31.6% and 9.1% in male rats and by 21.1% and 7.2% in female rats
exposed to BrdUrd and in their offspring, respectively. Exposure to BrdUrd
increased the aging rate of the rats and of their progeny. Age-related
changes in the length of the estrus cycle and in the incidence of persistent
estrus and/or anestrus were observed earlier in female rats exposed
neonatally to BrdUrd and in their offspring compared to controls; also,
developmental stigmas were observed in the offspring of rats exposed
neonatally. The incidence of total and malignant tumors was increased in rats
that had received BrdUrd as well as their progeny. Our observations on the
decrease in mean and maximum life span, the
increase in aging rate, the acceleration of age-related changes in female
reproductive system function, and the increase in tumor incidence and
decrease in tumor latency in rats exposed to BrdUrd in early
life suggest that this system could serve as a model of
accelerated aging. These effects persist at least to the next generation.
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