From: Joao Pedro de Magalhaes (joao.magalhaes@fundp.ac.be)
Date: Tue Nov 02 1999 - 04:19:04 MST
Hi!
Some time ago, you wrote:
>IMO the order of things that need to be corrected to prevent/reverse
>aging are:
> a) Telomere Loss
> b) Mitochondrial DNA damage
> c) Protein glycosylation
> d) Accumulation of non-digestable CaRbohydrAte/Protein/lipids [CRAP]
> d) Ribosomal DNA loss through recombination repair
> e) DNA damage causing the accumulation of mutations
>
>This list will get you the major causes of what we call aging.
Perhaps. But what about "use-related damage" or mechanical senescence that
might not be derived from aging itself. For example: presbyopia, molar
erosion, hardening of joints, and menopause. Species that appear not to age
have different physiologies that allow them to cope with these situations.
Even that we do not age, these problems might still affect us. Of course
this depends on how you define aging but I think that senescence and certain
age-related changes might be independent of one another (as predicted from
evolutionary theory).
Bye.
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