From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Wed Aug 25 1999 - 16:44:47 MDT
Authors
Stavrovskaia IG. Sirota TV. Saakian IR. Kondrashova MN.
Institution
Institute of Theoretical and Experimental Biophysics, Russian Academy of
Sciences, Pushchino, Moscow Region, Russia.
Title
[Optimization of energy-dependent processes
in mitochondria from rat liver and brain after inhalation of negative air
ions]. [Russian]
Source
Biofizika. 43(5):766-71, 1998 Sep-Oct.
Abstract
The effect of negative air ions (NAI) inhalation by rats on
energy reactions of mitochondria in homogenates of liver and
brain was studied. The influence of NAI was investigated under activation of
animals by administration of physiological dose of adrenaline. Adrenaline
administration induced hyperactivation of the rate of phosphorylating
oxidation of succinic acid in liver and brain mitochondria which was
accompanied by oxalacetate inhibition of succinate dehydrogenase (SDH) as
well as excessive Ca2+ accumulation in liver mitochondria. These changes
connected with a decrease of coefficient of phosphorylation efficiency ADP/O
and uncoupler stimulation of respiration evidenced decrease of
energy control of respiration in mitochondria. NAI
inhalation diminished the rate of hyperactivated respiration and abolished
excessive Ca2+ accumulation. These changes together with ADP/O coefficient
and DNP stimulation increase evidence improvement of energy
control of respiration which provide more moderate function of the
respiratory chain under activation by adrenaline. Animals were excited by
adrenaline administration. This effect was abolished by NAI inhalation,
animals relaxed, some fell asleep. The data evidence sensitivity of
mitochondrial processes in internal organs to inhalation of NAI and show
participation of mitochondria in realization of physiological effects of NAI.
Additional comment by poster:
It would be very interesting to see the effects of large doses of
negative air ions in the setting of an old age home.
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