From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Thu Jul 02 1998 - 21:39:59 MDT
Neurobiology of Aging 19(3): 273-276 1998
"Long-Term Food Restriction, Deprenyl, and Nimodipine Treatment on Life
Expectancy and Blood Pressure of Stroke-Prone Rats"
Abstract:
We determined whether food restriction or the drugs nimodipine (Ca2+
antagonist) and deprenyl (a MAO-B inhibitor) prevent the development of
stroke in the spontaneously hypertensive stroke-prone rat (SHR-SP). Forty
male SHR-SP rats, in the age of 34 weeks, were exposed to various
treatments. During a period of 27 weeks, survival and blood pressure were
followed. In the control and deprenyl group, the blood pressure values
remianed unchanged; 50% had died after 27 weeks. All rats that were treated
with nimodipine survived. After food restriction, 7/8 rats survived and
showed a lower blood pressure. This study in SHR-SP rats shows the
superiority of nimodipine on survival, and the potential of food
restriction as a stroke-preventing measure.
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