From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Wed Jul 01 1998 - 05:48:48 MDT
Authors
Huang MZ. Watanabe S. Kobayashi T. Nagatsu A. Sakakibara J. Okuyama H.
Institution
Faculty of Pharmaceutical Sciences, Nagoya City University, Japan.
Title
Unusual effects of some vegetable oils on the survival time of stroke-prone
spontaneously hypertensive rats.
Source
Lipids. 32(7):745-51, 1997 Jul.
Abstract
Preliminary experiments have shown that a diet containing 10% rapeseed oil
(low-erucic acid) markedly shortens the survival time of stroke-prone
spontaneously hypertensive (SHRSP) rats under 1% NaCl
loading as compared with diets containing perilla oil or soybean oil.
High-oleate safflower oil and high-oleate sunflower oil were found to have
survival time-shortening activities comparable to that of rapeseed oil; olive
oil had slightly less activity. A mixture was made of soybean oil, perilla
oil, and triolein partially purified from high-oleate sunflower oil to adjust
the fatty acid composition to that of rapeseed oil. The survival time of this
triolein/mixed oil group was between those of the rapeseed oil and soybean
oil groups. When 1% NaCl was replaced with tap water, the survival time was
prolonged by approximately 80%. Under these conditions, the rapeseed oil and
evening primrose oil shortened the survival time by approximately 40% as
compared with n-3 fatty acid-rich perilla and fish oil; lard, soybean oil,
and safflower oil with relatively high n-6/n-3 ratios shortened the survival
time by roughly 10%. The observed unusual survival time-shortening activities
of some vegetable oils (rapeseed, high-oleate safflower, high-oleate
sunflower, olive, and evening primrose oil) may not be due to their unique
fatty acid compositions, but these results suggest that these vegetable oils
contain factor(s) which are detrimental to SHRSP rats.
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