From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Wed Nov 27 2002 - 12:17:42 MST
On Wed, 27 Nov 2002, Anders Sandberg wrote:
> Vol. 96, Issue 5, 2445-2450, March 2, 1999
Yea, but thats *old* (though thanks for finding it) :-)
PubMed URL:
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=10051662&dopt=Abstract
But also of interest is:
Ahmad Z, Salim M, Maines MD.
"Human biliverdin reductase is a leucine zipper-like DNA-binding protein and functions in
transcriptional activation of heme oxygenase-1 by oxidative stress"
J Biol Chem. 2002 Mar 15;277(11):9226-32.
http://www.ncbi.nlm.nih.gov:80/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11773068&dopt=Abstract
(I'm sure the "Related Articles" to these contain some associated
information.)
> And why pour it into the gut? Maybe the gut flora produces free
> radicals.
I don't know. Is there a significant amount of macrophage
migration into the gut to keep the bacteria under control?
An assay to determine the fraction of human DNA vs. bacterial
DNA in stool samples can't be *that* hard. That and/or a
measurement of the level of oxidative stress in the gut
might be useful.
More interesting will be to determine the basic transport
mechanisms. I'm not absolutely positive but I would suspect
this is produced primarily in the liver and/or spleen. So
that would mean that in order for it to get to neurons there
would have to be multiple receptors and transport mechanisms
for it.
Rafal, congratulations (potentially) for winning the genetic
lottery. But we may need to count all of the eggs before they
are hatched and I doubt we can do that just yet.
I need to go dig out a biochemistry book and refresh my memory
on this topic but its about #5 on the priority list.
Robert
This archive was generated by hypermail 2.1.5 : Wed Jan 15 2003 - 17:58:26 MST