From: Smigrodzki, Rafal (SmigrodzkiR@msx.upmc.edu)
Date: Tue Jun 11 2002 - 11:49:18 MDT
Extropian Agro Forestry Ventures Inc. [mailto:megao@sk.sympatico.ca] wrote:
immune modulators especially ones with low overall toxicity are good
choices for long term support.
Non-hallucingenic cannabinoids are classed as neuroprotective antioxidants.
Cannabidiol is a good candidate. Find a hemp farmer and go get a few pounds
of buds. Freeze or gently dry and incorporate into foods.
Phase2 enzyme inducers of various origins most notably crucifer sprouts or
extracts therefrom have functionality in reducing neurological trauma from
disease processes.
Omega3 oils including GLA are long standing supportative chemistry for nerve
cells.
Alpha lipoic acid especially in quite large doses has in the literature
shown efficacy as supportative on a systemic basis.
### I would tend to agree with cautious use of the aforementioned chemicals,
although to my knowledge the evidence in their favor is circumstantial and
not directly related to MS.
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Piracetam and its related pyrrolidinone derivatives has fundamental utility
to optimize oxygen efficiency in mitichondria. Nerve cells under stress
need this kind of support. Go heavy on this 1-5 grams/ day would not be
excessive.
### I have some doubts about Nootropil. Aside from its efficacy against
myoclonus the evidence in its favor is scant.
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Recently 2 neurologists from Stanford presented a paper at FASEB about the
immune aspects of the statin drugs (ex-lipitor)commonly used to block
cholesterol. There is a strong recommendation to apply them to MS. They
are dose dependant so don't skimp. 80mg is safe for long term use. Split
this dose AM/PM
### I am not familiar with the paper mentioned here. In general I am a fan
of statins, for stroke and dementia prevention, with quite strong clinical
evidence. However, using large doses of statins is not without risk - there
is a fair frequency of liver toxicity, myopathy, and neuropathy, possibly
related to the interference in the synthesis of CoQ10. If you use statins
(as I do), titrate the dose to the minimum dose sufficient to attain the
target LDL/HDL ratio, and have regular medical follow-up, and consider CoQ10
supplements (unproven).
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antioxidants from the broad classification of the flavonoids, anthocyanins,
ponlphenols and their complex relatives the condensed and hydrolyzable
tannins are a strong personal recommendation for dietary support. Include
the soy isoflavones in this category.
### Won't harm, for sure. I take antioxidants as a general precaution,
despite lack of decisive evidence.
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The interferons, if your drug plan will cover them are good at forestalling
damaging plaque development.
### Interferons are the most crucial thing you can do. If your plan doesn't
cover them, change it if you can.
Rafal
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