From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Sun Dec 23 2001 - 01:14:55 MST
On Sat, 22 Dec 2001, Max More wrote:
> Thanks for the information Patrick. I stress my observations are
> subjective, but I do doubt the effectiveness of Modafinil.
I think it would be important to stress that effects of many,
perhaps most, cognitive modification agents are likely to be
subjective. We have very little information about how polymorphic
the various neurotransmitter release and receptor pathways are.
My read of the literature to date suggests there is a fairly
large degree of variance. One persons boon may be anothers bane.
One needs to be *very* specific with regard to chemical
structures of such drugs because of effects on absorption
as well as clearance. The clearance rates are likely to
be quite specific on an individual basis.
So this discussion should have a high dose of "your mileage
may vary".
Robert
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