From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Sat Aug 19 2000 - 18:48:35 MDT
Title
Ramipril vs captopril in mild to moderate
hypertension.
Source
Journal of the Association of Physicians of India. 42(2):120-3, 1994 Feb.
Abstract
Ramipril 5 mg once daily was compared to
Captopril 50 mg twice daily in a randomised, double-blind,
parallel group study in 60 patients with a diastolic blood pressure between
95 to 120 mmHg over a period of 2 months. Both drugs in the dose regimen used
in this study exerted a similar anti-hypertensive effect at the end of 2
months of treatment resulting in a fall of supine diastolic blood pressure
with Ramipril = 19.27 +/- 3.34 mmHg and
Captopril = 19.15 +/- 2.63, in patients receiving the drugs
without the diuretic. The mean fall in supine diastolic blood pressure 4
hours after the first dose of Ramipril was 6.5 mmHg and
Captopril 8 mmHg. None of the patients developed first dose
hypotension or orthostatic hypotension and there was no significant
alteration of the heart rate in either group. The serum K+ levels remained
unchanged in both groups of patients. Both drugs were well tolerated and
there were no adverse effects observed on the liver, kidney, blood sugar or
haemopoietic system. Based on the results of this study, it can be concluded
that the antihypertensive efficacy of 5 mg ramipril in a
once daily dose is equivalent to 50 mg captopril given twice
daily. However an appreciably greater number of patients reported improvement
in the "quality of life' parameters with ramipril as
compared to captopril. Thus for the routine treatment of
mild to moderate arterial hypertension, ramipril offers
reliable antihypertensive efficacy in a once daily dose, thereby helping to
improve patient compliance and making the treatment more economical.
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