<!DOCTYPE html>
<!--[if lt IE 7]> <html lang="en" class="no-js ie6 lt-ie9 lt-ie8"> <![endif]-->
<!--[if IE 7]> <html lang="en" class="no-js ie7 lt-ie9 lt-ie8"> <![endif]-->
<!--[if IE 8]> <html lang="en" class="no-js ie8 lt-ie9"> <![endif]-->
<!--[if IE 9]> <html lang="en" class="no-js ie9"> <![endif]-->
<!--[if gt IE 9]><!--> <html lang="en" class="no-js"> <!--<![endif]-->
<head>
<meta charset="UTF-8"/>
<meta name="description" content=""/>
<meta name="author" content=""/>
<meta name="viewport" content="width=device-width, minimum-scale=1, maximum-scale=1"/>
<meta name="format-detection" content="telephone=no"/>
<meta name="citation_publisher" content="Springer Berlin Heidelberg"/>
<meta name="citation_title" content="The Role of Cyclic Nucleotides in Platelets"/>
<meta name="citation_firstpage" content="723"/>
<meta name="citation_lastpage" content="761"/>
<meta name="citation_doi" content="10.1007/978-3-642-68393-0_20"/>
<meta name="citation_language" content="en"/>
<meta name="citation_abstract_html_url" content="http://link.springer.com/chapter/10.1007/978-3-642-68393-0_20"/>
<meta name="citation_pdf_url" content="http://link.springer.com/content/pdf/10.1007%2F978-3-642-68393-0_20.pdf"/>
<meta name="citation_springer_api_url" content="http://api.springer.com/metadata/pam?q=doi:10.1007/978-3-642-68393-0_20&api_key="/>
<meta name="citation_author" content="D. C. B. Mills"/>
<meta name="citation_inbook_title" content="Cyclic Nucleotides"/>
<meta name="citation_isbn" content="978-3-642-68395-4"/>
<meta name="citation_isbn" content="978-3-642-68393-0"/>
<meta name="citation_publication_date" content="1982/01/01"/>
<meta name="twitter:card" content="summary"/>
<meta name="twitter:title" content="The Role of Cyclic Nucleotides in Platelets"/>
<meta name="twitter:description" content="Cyclic AMP in blood platelets is regulated by several endogenous factors and can also be influenced by drugs. Elevation of platelet cAMP, either by inhibition of phosphodiesterase or by stimulation of"/>
<meta name="twitter:image" content="http://link.springer.com/static-content/covers/books/978/9783642683930.jpg"/>
<meta name="twitter:site" content="SpringerSBM"/>
<!--[if (gt IE 8) | (IEMobile)]><!--> <link rel="stylesheet" media="screen" href="/static/0.8657/css/modern_link.min.css"> <!--<![endif]-->
<!--[if (lt IE 9) & (!IEMobile)]> <link rel="stylesheet" media="screen" href="/static/0.8657/css/ielt9_link.min.css"> <![endif]-->
<link rel="stylesheet" media="print" href="/static/0.8657/css/print.css"/>
<link rel="apple-touch-icon-precomposed" size="144x144" href="/static/0.8657/sites/link/images/apple-touch-icon-144x144-precomposed.png"/>
<link rel="apple-touch-icon-precomposed" size="114x114" href="/static/0.8657/sites/link/images/apple-touch-icon-114x114-precomposed.png"/>
<link rel="apple-touch-icon-precomposed" size="72x72" href="/static/0.8657/sites/link/images/apple-touch-icon-72x72-precomposed.png"/>
<link rel="apple-touch-icon-precomposed" size="57x57" href="/static/0.8657/sites/link/images/apple-touch-icon-57x57-precomposed.png"/>
<link rel="apple-touch-icon-precomposed" href="/static/0.8657/sites/link/images/apple-touch-icon-57x57-precomposed.png"/>
<link rel="shortcut icon" href="/static/0.8657/sites/link/images/favicon-32x32.png"/>
<!--[if IE]>
<link rel="shortcut icon" href="/static/0.8657/sites/link/images/favicon.ico"/>
<![endif]-->
<meta name="msapplication-TileColor" content="#FFFFFF"/>
<meta name="msapplication-TileImage" content="/static/0.8657/sites/link/images/ms-tileimage.png"/>
<link rel="canonical" href="http://link.springer.com/chapter/10.1007%2F978-3-642-68393-0_20"/>
<script type="text/javascript">window.jsErrors = [];window.onerror = function(errorMessage) {window.jsErrors[window.jsErrors.length] = errorMessage;}</script>
<script>document.documentElement.className = document.documentElement.className.replace(/\bno-js\b/,'js');</script>
<script type="text/javascript">
var _gaq = _gaq || [];
</script>
<script type="text/javascript">
var googletag = googletag || {};
googletag.cmd = googletag.cmd || [];
(function() {
var gads = document.createElement('script');
gads.async = true;
gads.type = 'text/javascript';
var useSSL = 'https:' == document.location.protocol;
gads.src = (useSSL ? 'https:' : 'http:') +
'//www.googletagservices.com/tag/js/gpt.js';
var node = document.getElementsByTagName('script')[0];
node.parentNode.insertBefore(gads, node);
})();
</script>
<script type="text/javascript" id="googletag-push">
googletag.cmd.push(function() {
googletag.defineSlot('6313/casper/book/chapter', [160, 600], 'doubleclick-ad').addService(googletag.pubads());
googletag.pubads().setTargeting("eisbn","978-3-642-68393-0");
googletag.pubads().setTargeting("pisbn","978-3-642-68395-4");
googletag.pubads().setTargeting("eissn","1865-0325");
googletag.pubads().setTargeting("pissn","0171-2004");
googletag.pubads().setTargeting("doi","10.1007-978-3-642-68393-0_20");
googletag.pubads().setTargeting("sucode",["SUCO11642"]);
googletag.pubads().setTargeting("pmc",["B","B21007","F00008"]);
googletag.pubads().setTargeting("BPID",["3000165890","8200420897"]);
googletag.pubads().enableSingleRequest();
googletag.enableServices();
});
</script>
<title>The Role of Cyclic Nucleotides in Platelets - Springer</title>
</head>
<body class="company link" data-name="link">
<div id="wrapper">
<div id="header" role="banner">
<h1>
<a id="logo" href="/">
<img src="/static/0.8657/sites/link/images/logo-base.png" alt="Logo Springer" title="SpringerLink"/>
</a>
</h1>
<div class="panel-search">
<form id="global-search" class="big-search" action="/search" method="get" role="search">
<div class="search-field">
<input id="query" class="text" name="query" type="text" autocomplete="off" value="" placeholder="Search" title="Search"/>
</div>
<input id="search" class="search-submit" type="submit" value="Submit" title="New Search"/>
<div id="search-options" class="flyout">
<button class="pillow-btn open-search-options" title="Open search options" type="button">Search Options</button>
<div class="flyout-content">
<ul>
<li>
<a id="advanced-search-link" href="/advanced-search">Advanced Search</a>
</li>
<li>
<a id="search-help-link" href="/searchhelp">Search Help</a>
</li>
</ul>
</div>
</div>
</form>
</div>
<button class="pillow-btn open-search" title="Open search">Search</button>
<button class="pillow-btn open-menu" title="Open menu">Menu</button>
<div class="panel-menu">
<div id="cross-nav">
<div id="auth" class="flyout">
<button class="flyout-caption">Sign up / Log in</button>
<div class="flyout-content">
<ul>
<li>
<a id="register-link" class="action" href="/signup-login?previousUrl=%2Fchapter%2F10.1007%2F978-3-642-68393-0_20%3Fno-access%3Dtrue">Sign up / Log in</a>
<a id="institutional-link" class="action" href="/institutional-login?previousUrl=%2Fchapter%2F10.1007%2F978-3-642-68393-0_20%3Fno-access%3Dtrue">Institutional / Athens login</a>
</li>
</ul>
</div>
</div>
<div id="lang" class="flyout">
<button class="flyout-caption cur">English</button>
<div class="flyout-content">
<ul>
<li>
<a id="change-language-Deutsch" href="/language/Deutsch" rel="nofollow">Deutsch</a>
</li>
</ul>
</div>
</div>
<div id="edition" class="flyout">
<button class="flyout-caption cur">Academic edition</button>
<div class="flyout-content">
<ul>
<li>
<a class="edition-select" href="/siteEdition/rd" rel="nofollow">Corporate edition</a>
</li>
</ul>
</div>
</div>
</div>
<!-- /- giving kb-only user the option to skip to relevant content (see KeyboardNavigation.js) -->
<div id="skip-navigation">
<p class="skip-navigation--label">
<span>Skip to:</span>
<a href="#kb-nav--main">Main content</a>
<a href="#kb-nav--aside">Side column</a>
</p>
</div>
<div id="logo-company">
<img class="first" src="/content/companylogo/8200420897" alt="PORTLAND STATE UNIV">
<div></div>
</img>
</div>
<ul id="global-nav" class="clearfix" role="navigation">
<li>
<a href="/">Home</a>
</li>
<li>
<a href="/contactus">Contact Us</a>
</li>
</ul>
</div>
</div>
<div id="content">
<input id="autoShowLookInside" type="hidden" value="false"/>
<div id="chapter" class="document no-access" itemscope="itemscope" itemtype="http://schema.org/ScholarlyArticle">
<div class="bar-dock">
<div class="bar-wrapper">
<div class="bar-actions">
<span class="action icon-view">
<a class="lookinside-href webtrekk-track pdf-link" href="/chapter/10.1007%2F978-3-642-68393-0_20/lookinside/000.png" title="Look Inside" pageType="rd_springer_com.book.chapter_preview" doi="10.1007/978-3-642-68393-0_20" parentDoi="10.1007/978-3-642-68393-0" parentContentType="Book" contentType="Chapter" publication="10.1007/978-3-642-68393-0 | Cyclic Nucleotides" viewType="Preview">Look Inside</a>
</span>
<span class="action icon-unlock">
<a class="access-link webtrekk-track" href="/accesspage/chapter/10.1007/978-3-642-68393-0_20?coverImageUrl=%2Fstatic-content%2Fcovers%2Fbooks%2F978%2F9783642683930.jpg" title="Get Access" pageType="rd_springer_com.book.chapter_denial" doi="10.1007/978-3-642-68393-0_20" parentContentType="Book" contentType="Chapter" publication="10.1007/978-3-642-68393-0 | Cyclic Nucleotides" viewType="Denial">Get Access</a>
</span>
</div>
<div class="unlock-wrapper">
<div class="bar-access-restr">
<strong class="message">Find out how to access preview-only content</strong>
</div>
</div>
</div>
</div>
<div id="kb-nav--main" class="document-main layout-3">
<div id="kb-nav--main" class="col-main has-full-enumeration" role="main">
<div id="enumeration">
<div id="publication-title">
<a href="/book/10.1007/978-3-642-68393-0">Cyclic Nucleotides</a>
</div>
<a id="series-title" href="/bookseries/164">Handbook of Experimental Pharmacology</a>
<span id="book-volume">Volume 58 / 2, </span>
<span id="copyright-year">1982, </span>
<span id="page-range">
pp 723-761
</span>
</div>
<h1 id="title" itemprop="headline">The Role of Cyclic Nucleotides in Platelets</h1>
<div class="author-list">
<ul class="authors">
<li class="author" itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person">
<a href="/search?facet-author=%22D.+C.+B.+Mills%22" itemprop="name">D. C. B. Mills</a> </li>
<li class="show-all-hide-authors">
<span class="more-authors">…</span>
<span class="show-all-authors">show all 1</span>
<span class="hide-authors">hide</span>
</li>
</ul></div>
<div id="abstract-actions" class="panel">
<div class="content-pricing leaf-pricing">
<div class="leaf-pricing-content">
<div id="price-promo-message" class="hidden">
<div class="shout-out">
<p></p>
</div>
</div>
<div class="leaf-pricing-wrapper"></div>
<form id="getaccess-webshop" action="http://www.springer.com/?SGWID=0-1740713-3130-0-0&wt_mc=SpringerLink-_-AbstractPage-_-EPM653-_-Chapter" method="post">
<input type="hidden" name="mac" value="65bc80f2b79722630091eb5a0c37a6d4"/>
<input type="hidden" name="returnurl" value="http://link.springer.com/chapter/10.1007/978-3-642-68393-0_20"/>
<input type="hidden" name="contenttitle" value="The Role of Cyclic Nucleotides in Platelets"/>
<input type="hidden" name="pages" value="723-761"/>
<input type="hidden" name="copyrightyear" value="1982"/>
<input type="hidden" name="year" value="1982"/>
<input type="hidden" name="seriestitle" value="Handbook of Experimental Pharmacology"/>
<input type="hidden" name="authors" value="D. C. B. Mills"/>
<input type="hidden" name="title" value="Cyclic Nucleotides"/>
<input type="hidden" name="type" value="chapter"/>
<input type="hidden" name="doi" value="10.1007/978-3-642-68393-0_20"/>
<input type="hidden" name="volume" value="58 / 2"/>
<input type="hidden" name="isxn" value="978-3-642-68393-0"/>
<input id="leaf-pricing-buy-now" class="btn btn-primary btn-action btn-monster" value="Buy chapter" type="submit"/>
<div id="display-leaf-ppv">
<a href="/leaf-pricing/chapter/10.1007/978-3-642-68393-0_20"></a>
</div>
</form>
</div>
<div class="line-divider"></div>
<div id="display-book-ppv">
<a class="btn btn-primary btn-action btn-monster" href="/pricing/chapter/10.1007/978-3-642-68393-0_20">Buy this eBook</a>
</div>
</div>
<p class="price-disclaimer">* Final gross prices may vary according to local VAT.</p>
<span class="action icon-unlock">
<a id="request-access-link" class="webtrekk-track" href="/accesspage/chapter/10.1007/978-3-642-68393-0_20?coverImageUrl=%2Fstatic-content%2Fcovers%2Fbooks%2F978%2F9783642683930.jpg" pageType="rd_springer_com.book.chapter_denial" doi="10.1007/978-3-642-68393-0_20" contentType="Chapter" parentContentType="Book" viewType="Denial" publication="10.1007/978-3-642-68393-0 | Cyclic Nucleotides">Get Access</a>
</span>
</div>
<h2 class="abstract-heading">Overview</h2>
<div class="abstract-content formatted" itemprop="description">
<p class="a-plus-plus">Cyclic AMP in blood platelets is regulated by several endogenous factors and can also be influenced by drugs. Elevation of platelet cAMP, either by inhibition of phosphodiesterase or by stimulation of adenylate cyclase, leads to the suppression of their responsiveness to stimulation, and their participation in haemostatic and thrombotic processes is reduced.</p>
<p class="a-plus-plus">Platelet adenylate cyclase is regulated by specific receptors for prostaglandins I<sub class="a-plus-plus">2</sub> and D<sub class="a-plus-plus">2</sub>, for adenosine (“P”- and “R”-type receptors) and for ADP and catecholamines, (<em class="a-plus-plus">α</em> and <em class="a-plus-plus">β</em>. PGI<sub class="a-plus-plus">2</sub>, PGE<sub class="a-plus-plus">1</sub>, PGD<sub class="a-plus-plus">2</sub> adenosine and <em class="a-plus-plus">β</em>-adrenergic agonists stimulate adenylate cyclase activity; ADP and <em class="a-plus-plus">α</em>-adrenergic agonists inhibit the enzyme. Both receptor-mediated stimulation and inhibition are influenced by intracellular guanine nucleotides. The enzyme is also stimulated by histamine, cholera toxin and fluoride ion. Adenosine, acting on an intracellular “P” receptor, proaggregatory prostaglandins and endoperoxides inhibit the enzyme.</p>
<p class="a-plus-plus">Platelets have three cyclic nucleotide phosphodiesterases, one relatively specific for cAMP (FI), one for cGMP (FIII) and a nonspecific, low affinity enzyme (FII). They differ in their physical characteristics, and in their susceptibility to inhibition by a variety of drugs.</p>
<p class="a-plus-plus">Two cAMP-dependent protein kinases (type I and type II) have been detected, and an increase in platelet cAMP is associated with the phosphorylation of two membrane proteins, and with an increased ability of membrane vesicles to accumulate calcium. Many of the effects of cAMP may be mediated by the consequent reduction in intracellular free calcium ions.</p>
<p class="a-plus-plus">Platelets have a powerful guanylate cyclase which, in contrast to the adenylate cyclase, is not membrane bound. The cGMP level in platelets is rapidly elevated during aggregation, and also when guanylate cyclase is stimulated by a variety of drugs, including inhibitors of aggregation (azide, nitroprusside), aggregating agents (fatty acids, calcium ionophore) and some compounds having no detectable effect on aggregation (ascorbic acid).</p>
<p class="a-plus-plus">Elevation of cGMP level is a consequence rather than a cause of aggregation, and the function of this nucleotide remains a mystery.</p>
<p class="a-plus-plus">Abnormalities of cAMP metabolism have been recognised in some conditions, Bartter’s syndrome, essential thrombocythemia and acute thrombosis, in which platelet haemostatic function is abnormal, as well as others in which no functional abnormally has been detected. It is possible that the adenylate cyclase system of platelets may have a useful role as an indicator of events occurring in the brain or in other inaccessible organs.</p>
</div>
</div>
<div id="kb-nav--aside" class="col-aside" role="complementary">
<div class="cover">
<div class="look-inside cover-image-animate">
<div id="reader-overlay">
<div id="reader-page-template">
<div id="page-%P">
<div class="page-number">
Page
%P
</div>
<div class="pdf-page" id="page-img-container-%ID">
<img id="pdf-page-image-%ID" class="pdf-image" src="/static/0.8657/images/pdf-preview/spacer.gif" alt="Loading..." width="%W" style="width:%Wpx;" data-loaded="false"/>
</div>
</div>
</div>
<div class="reader-position">
<div id="reader">
<div id="reader-buttons">
<a href="#close" id="pdf-close" class="btn btn-close right">
Close
</a>
<a href="#close" id="toggletext" class="btn" title="Toggle plain text">
Plain text
</a>
</div>
<div id="viewer" class="show-pdf">
<div id="scroller"></div>
</div>
<div class="top-shadow"></div>
<div class="bottom-shadow"></div>
</div>
</div>
</div>
<a class="webtrekk-track lookinside-href" href="/chapter/10.1007%2F978-3-642-68393-0_20/lookinside/000.png" pageType="rd_springer_com.book.chapter_preview" parentContentType="Book" contentType="Chapter" doi="10.1007/978-3-642-68393-0_20" viewType="Preview" publication="10.1007/978-3-642-68393-0 | Cyclic Nucleotides">
<img class="look-inside-cover" src="/static-content/covers/books/978/9783642683930.jpg" alt="Cyclic Nucleotides" width="153" itemprop="image"/>
<img class="look-inside-page" src="/static-content/lookinside/222/chp%253A10.1007%252F978-3-642-68393-0_20/000.png" alt="Cyclic Nucleotides" width="153" itemprop="image"/>
<span class="look-inside-badge">
Look
<br/>
Inside
</span>
</a>
</div>
</div>
<div class="abstract-numbers">
<a id="citation-link" class="abstract-numbers__citations external external-quiet hidden" target="_blank" href="http://citationsapi.nkb3.org/article/citations/count">
<span class="abstract-numbers__count"></span>
<span class="abstract-numbers__label">Citations</span>
</a>
<span class="social-mention"></span>
</div>
<div class="partner-logos">
<ul>
</ul>
</div>
<div class="section-links">
</div>
<div class="other-actions">
<h2>Other actions</h2>
<ul>
<li>
<a id="permissions-link" class="external" href="https://s100.copyright.com/AppDispatchServlet?publisherName=Springer&orderBeanReset=true&orderSource=SpringerLink&author=D.+C.+B.+Mills&contentID=10.1007%2F978-3-642-68393-0_20&openAccess=false&endPage=761&publicationDate=1982&startPage=723&title=The+Role+of+Cyclic+Nucleotides+in+Platelets&imprint=Springer-Verlag+Berlin+Heidelberg&publication=eBook" target="_blank" title="It opens in new window">Reprints and Permissions</a>
</li>
<li>
<a id="export-citation" href="/export-citation/chapter/10.1007/978-3-642-68393-0_20">
Export citation
</a>
</li>
<li>
<a id="about-link" class="external" href="http://www.springer.com/978-3-642-68395-4" target="_blank" title="It opens in new window">
About this Book
</a>
</li>
<li>
<a id="papers-link" class="external webtrekk-track" href="http://redirect.papersapp.com/redirect?url=http://link.springer.com/chapter/10.1007%2F978-3-642-68393-0_20" target="_blank" title="It opens in new window" gaCategory="Papers" publication="10.1007/978-3-642-68393-0_20 | The Role of Cyclic Nucleotides in Platelets" viewType="Add to Papers">Add to Papers</a>
</li>
</ul>
</div>
<div class="other-actions share">
<h2>Share</h2>
<a id="facebook" href="javascript:void(0)" title="Share this content on Facebook">Share this content on Facebook</a>
<a id="twitter" href="javascript:void(0)" title="Share this content on Twitter">Share this content on Twitter</a>
<a id="linkedin" href="javascript:void(0)" title="Share this content on LinkedIn">Share this content on LinkedIn</a>
</div>
</div>
</div>
<div id="kb-nav--aside" class="document-aside" role="complementary">
<input id="useUnsilo" type="hidden" value="false"/>
<div id="abstract-related" class="hidden expander">
<div class="expander-title">
<div class="heading">
<button>
<h2>Related Content</h2>
<img class="hidden" src="/static/0.8657/sites/link/images/loading_expander.gif" alt="loading..."/>
</button>
</div>
</div>
<div class="expander-content">
<div class="expander-content-inner">
<ol id="related-list"></ol>
</div>
</div>
</div>
<div id="abstract-esm" class="expander expander-empty">
<div class="expander-title">
<div class="heading">
<h2>
<button>Supplementary Material (0)</button>
</h2>
</div>
</div>
</div>
<div id="abstract-references" class="expander">
<div class="expander-title">
<div class="heading">
<h2>
<button>References (307)</button>
</h2>
</div>
</div>
<div class="expander-content">
<div class="expander-content-inner">
<div class="formatted">
<ol>
<li>
<span class="authors">Abdulla YH (1969) <em class="a-plus-plus">β</em>-adrenergic receptors in human platelets. J Atherosclerosis Res 9:171–177</span>
<a class="external" href="http://dx.doi.org/10.1016/S0368-1319(69)80052-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Abdulla YH, Hamadah K (1975) Effects of ADP on PGE<sub class="a-plus-plus">1</sub>-formation in blood platelets from patients with depression mania and schizophrenia. Br J Psychiatry 127:591–595</span>
<a class="external" href="http://dx.doi.org/10.1192/bjp.127.6.591" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Adams AF, Haslam RJ (1978) Factors affecting the activity of guanylate cyclase in lysates of human blood patelets. Biochem J 174:23–35</span>
</li>
<li>
<span class="authors">Adelstein RL, Conti MA, Barylko B (1978) The role of myosin phosphorylation in regulating actin-myosin interaction in human blood platelets. Thromb Haemost 40:241–244</span>
</li>
<li>
<span class="authors">Adler JR, Handin RI (1979) Solubilization and characterization of a platelet membrane ADP-binding protein. J Biol Chem 254:3866–3872</span>
</li>
<li>
<span class="authors">Agarwal KC, Steiner M (1976) Effect of serotonin on cyclic nucleotides of human platelets. Biochem Biophys. Res Commun 69:962–969</span>
</li>
<li>
<span class="authors">Akkerman JWN, Gorter G, Sixma JJ, Stahl GEJ (1979) Influence of sulphate on effect of ADP, 3′,5′-cyclic AMP and citrate on human platelet phosphofructokinase activity. Int J Biochem 5:853–857</span>
<a class="external" href="http://dx.doi.org/10.1016/0020-711X(74)90120-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Alexander RW, Cooper B, Handin RI (1978) Characterization of human platelet alpha adrenergic receptor — correlation of (<sup class="a-plus-plus">3</sup>H) dihydroergocryptine binding with aggregation and adenylate cyclase inhibition. J Clin Invest 61:1136–1144</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI109028" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Amer M, Marquis NR (1972) The effect of prostaglandins, epinephrine and aspirin on cAMP phosphodiesterase activity of human blood platelets and their aggregation. In: Prostaglandins in cellular biology. Plenum Press, New York London, pp 93–105</span>
</li>
<li>
<span class="authors">Amer MS, Maynol RF (1973) Studies with phosphodiesterase III. Two forms of the enzyme from human blood platelets. Biochim Biophys Acta 309:149–156</span>
</li>
<li>
<span class="authors">Amer MS, McKinney GR (1973) Possibilities for drug development based on the cyclic AMP system. Life Sci 13:753–767</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(73)90066-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Anderson NH, Eggerman TL, Harker LA, Wilson CHD (1980) On the multiplicity of platelet prostaglandin receptors. I. Evaluation of competitive antagonism by aggregometry. Prostaglandins 19:711–755</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(80)90170-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Apitz-Castro R, DeMurciano A (1978) Modulation of platelet responsiveness through selective phosphorylation of plasma membrane proteins. Biochim Biophys Acta 544:529–539</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(78)90327-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Apitz-Castro R, Ramirez E, Maignon R, DeMurciano A, Ribbi A (1976) Plasma membrane phosphorylation by endogenous phosphate donors in human blood platelets. Selectivity of the action of cyclic AMP. Biochim Biophys Acta 455:371–382</span>
<a class="external" href="http://dx.doi.org/10.1016/0005-2736(76)90312-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Ardlie NG, Glew G, Schwartz CJ (1966) Influence of catecholamines on nucleotide-induced platelet aggregation. Nature 212:415–416</span>
<a class="external" href="http://dx.doi.org/10.1038/212415a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Ardlie NG, Glew G, Schultz BG, Schwartz CJ (1967) Inhibition and reversal of platelet aggregation by methyl xanthines. Thromb Diath Haemorrh 18:670–673</span>
</li>
<li>
<span class="authors">Asano T, Hidaka H (1977) Purification of guanylate cyclase from human platelets and the effect of arachidonic acid peroxide. Biochem Biophys Res Commun 78:910–918</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(77)90509-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Asano T, Ochai Y, Hidaka H (1977) Selective inhibition of separated forms of human platelet cyclic nucleotide phosphodiesterase by platelet aggregation inhibitors. Mol Pharmacol 13:400–406</span>
</li>
<li>
<span class="authors">Assaf SF (1976) Cyclic AMP mediated phosphorylation reactions in the regulation of blood platelet aggregation. Int J Biochem 7:535–540</span>
<a class="external" href="http://dx.doi.org/10.1016/0020-711X(76)90071-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Assaf SF (1977) Human platelet protein kinases reaction with platelet membranes and cytoplasmic enzymes and crystalization of a cyclic AMP-dependent protein kinase. Ann NY Acad Sci 283:159–174</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1749-6632.1977.tb41763.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Ball G, Brereton GG, Fulwood M, Ireland DM, Yates P (1970) Effect of prostaglandin E<sub class="a-plus-plus">1</sub> alone or in combination with theophylline or aspirin on collagen induced platelet aggregation and on platelet nucleotides including adenosine 3′,5′ monophosphate. Biochem J 102:709–718</span>
</li>
<li>
<span class="authors">Barber AJ (1976). Cyclic nucleotides and platelet aggregation. Effect of aggregating agents on the activity of cyclic nucleotide metabolizing enzymes. Biochim Biophys Acta 444:579–595</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(76)90402-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Barnes FS, Gamow E, Burns A, deBoisfleury A (1974) Directional effects of cyclic AMP on platelets. Clin Sci Mol Med 46:307–309</span>
</li>
<li>
<span class="authors">Best LC, Martin TJ, Russell RGG, Preston FE (1977) Prostacyclin increases cyclic AMP levels and adenylate cyclase activity in platelets. Nature 267:850–851</span>
<a class="external" href="http://dx.doi.org/10.1038/267850a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Best LC, McGuire MB, Jones PBB, Holland TK, Martin TJ, Preston FE, Segal DS, Russell RGG (1979 a) Mode of action of dipyridamole on human platelets. Thromb Res 16:367–379</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(79)90084-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Best LC, McGuire MB, Martin TJ, Preston FE, Russell RGG (1979 b) Effects of epoxymethano analogs of prostaglandin endoperoxides on aggregation, on release of 3′, 5′-cyclic AMP and cyclic GMP in human platelets. Biochim Biophys Acta 583:344–351</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(79)90458-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Bishop GA, Rosenberg MC (1975) The effect of ADP, calcium and some inhibitors of platelet aggregation on protein phosphokinases from human blood platelets. Biochim Biophys Acta 385:112–119</span>
</li>
<li>
<span class="authors">Bohme E, Jakobs KH (1973) Guanosine 3:5-monophosphate in human platelets. IRC Int Res Com Sys 1:30</span>
</li>
<li>
<span class="authors">Bohme E, Jung R, Mechler I (1974) Guanylate cyclase in human platelets. Methods Enzymol 38C:199–202</span>
<a class="external" href="http://dx.doi.org/10.1016/0076-6879(74)38032-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Booyse FM, Marr J, Young DC, Guiliani D, Rafelson ME (1967) Adenosine cyclic 3′,5′-monophosphate-dependent protein kinase from human platelets. Biochim Biophys Acta 422:60–72</span>
</li>
<li>
<span class="authors">Booyse FM, Guiliani D, Marr JJ, Rafelson ME (1973) Cyclic adenosine 3′,5′-monophosphate dependent protein kinase of human platelets: membrane phosphorylation and regulation of platelet function. Ser Haematol 6:351–366</span>
</li>
<li>
<span class="authors">Born GVR, Cross MJ (1963) Inhibition of the aggregation of blood platelets by substances related to adenosine diphosphate. J Physiol 166:29–30 P</span>
</li>
<li>
<span class="authors">Bousser M-G (1973) Prostaglandin E<sub class="a-plus-plus">1</sub> and platelets. Biomedicine 1:95–102</span>
</li>
<li>
<span class="authors">Brodie GN, Baenziger NL, Chase LR, Majerus PW (1972) The effects of thrombin on adenylate cyclase activity and a membrane protein from human platelets. J Clin Invest 51:81–88</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI106800" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Bruno JJ, Taylor LA, Droller MJ (1974) Effects of prostaglandin E<sub class="a-plus-plus">2</sub> on human platelet adenylate cyclase and aggregation. Nature 251:721–723</span>
<a class="external" href="http://dx.doi.org/10.1038/251721a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Bunting S, Gryglewski R, Moncada S, Vane JR (1976) Arterial walls generate from prostaglandin endoperoxides a substance (prostaglandin X) which relaxes strips of mesenteric and coeliac arteries and inhibits platelet aggregation. Prostaglandins 12:897–913</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(76)90125-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Chiang TM, Beachey EH, Kang AH (1975) Interaction of a chick skin collagen fragment (<em class="a-plus-plus">α</em>1-CB 5) with human platelets. J Biol Chem 250:6916–6922</span>
</li>
<li>
<span class="authors">Chiang TM, Dixit SN, Kang AH (1976) Effect of 3′,5′-guanosine monophosphate on human platelet function. J Lab Clin Med 88:215–221</span>
</li>
<li>
<span class="authors">Chuang HYK, Shermer RW, Mason RG (1974) Acetylcholine-induced release reaction of canine platelets. Res Commun Chem Pathol Pharmacol 7:330–346</span>
</li>
<li>
<span class="authors">Claesson H-E, Malmsten C (1977) On the relationship of prostaglandin endoperoxide G<sub class="a-plus-plus">2</sub> and cyclic nucleotides in platelet function. Eur J Biochem 76:277–284</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1432-1033.1977.tb11593.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cole B, Robison GA, Hartmann RC (1971) Studies on the role of cyclic AMP in platelet function. Ann NY Acad Sci 185:477–487</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1749-6632.1971.tb45274.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Colman RW, Figures WR, Colman RF, Morinelli TA, Niewiarowski S, Mills DCB (1980) Identification of two distinct adenosine diphosphate receptors in human platelets. Trans Am Soc Phys 93:305–316</span>
</li>
<li>
<span class="authors">Cooper B (1979 a) Diminished platelet adenylate cyclase activation by prostaglandin D<sub class="a-plus-plus">2</sub> in acute thrombosis. Blood 54:694–693</span>
</li>
<li>
<span class="authors">Cooper B (1979 b) Agonist regulation of the human platelet D<sub class="a-plus-plus">2</sub> receptor. Life Sci 25:1361–1368</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(79)90412-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cooper B, Ahern D (1979) Characterization of the platelet prostaglandin D<sub class="a-plus-plus">2</sub> receptor. J Clin Invest 64:586–590</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI109497" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cooper B, Handin RI, Young LH, Alexander RW (1978 a) Agonist regulation of the human platelet <em class="a-plus-plus">α</em>-adrenergic receptor. Nature 274:703–706</span>
<a class="external" href="http://dx.doi.org/10.1038/274703a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cooper B, Shafer AI, Puchalsky D, Handin RI (1978 b) Platelet resistance to prostaglandin D<sub class="a-plus-plus">2</sub> in patients with myeloproliferative disorders. Blood 52:618–626</span>
</li>
<li>
<span class="authors">Cooper B, Schaffer AI, Puchalsky D, Handin RI (1979) Desensitization of prostaglandin activated platelet adenylate cyclase. Prostaglandins 17:561–571</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(79)90007-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cooper DMF, Rodbell M (1979) ADP is a potent inhibitor of human platelet plasma membrane adenylate cyclase. Nature 282:517–518</span>
<a class="external" href="http://dx.doi.org/10.1038/282517a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cusack NJ, Hickman ME, Born GVR (1979) Effects of D and L enantiomers of adenosine, AMP, ADP and their 2-azido-analogues on human platelets. Proc R Soc Lond [Biol] 206:139–144</span>
<a class="external" href="http://dx.doi.org/10.1098/rspb.1979.0097" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Cuthbertson WFJ, Mills DCB (1963) Some factors influencing platelet clumping. J Physiol 169:9P</span>
</li>
<li>
<span class="authors">Cutler L, Rodan G, Feinstein MB (1978) Cytochemical localization of adenylate cyclase and of calcium ion, magnesium ion activated ATP’ase in the dense tubular system of human blood platelets. Biochim Biophys Acta 542:357–371</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(78)90367-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Daniel JL, Holmsen H, Adelstein RS (1977) Thrombin-stimulated myosin phosphorylation in intact platelets and its possible involvement in secretion. Thromb Haemost 38:984–989</span>
</li>
<li>
<span class="authors">DaPrada M, Burckhard WP, Pletscher A (1972) Cyclic AMP of blood platelets: accumulation in organelles storing 5 hydroxytryptamine and ATP. Experientia 72:845</span>
<a class="external" href="http://dx.doi.org/10.1007/BF01923167" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Davies T, Davidson MML, McGlenaghan MD, Saye A, Haslam RJ (1976) Factors affecting platelet cyclic GMP levels during aggregation induced by collagen and by arachidionic acid. Thromb Res 9:387–405</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(76)90139-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Dechavanne M, Lagarde M (1974) Mise en evidence de deux compartements d’AMP cyclique dans des suspensions de plaquettes humaines. Pathol Biol 22:17–21</span>
</li>
<li>
<span class="authors">Dembinska-Kiec A, Rucker W, Schonhofer PS (1979 a) Effect of dipyridamole in experimental atherosclerosis. Action on PGI<sub class="a-plus-plus">2</sub>, platelet aggregation and atherosclerotic plaque formation. Atherosclerosis 33:315–327</span>
<a class="external" href="http://dx.doi.org/10.1016/0021-9150(79)90183-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Dembinska-Kiec A, Rucker W, Schonhofer PS (1979 b) Effects of dipyridamole in vivo on ATP and cAMP content in platelets and arterial walls and on atherosclerotic plaque formation. Arch Pharmacol 309:59–64</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00498756" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Demopoulos CA, Pinkard RN, Hanahan DJ (1979) Platelet activating factor. Evidence for 1–0-alkyl-2-acetyl-sn-glycerol-3-phosphoryl choline as the active component (a new class of lipid chemical mediators). J Biol Chem 254:9355–9358</span>
</li>
<li>
<span class="authors">Detwiler TC, Charo IF, Feinman RD (1978) Evidence that calcium regulates platelet function. Thromb Haemost 40:207–211</span>
</li>
<li>
<span class="authors">Diesseroth A, Wolfe SM, Shulman NR (1970) Platelet Phosphorylase activity in the presence of activators an inhibitors of aggregation. Biochem Biophys Res Commun 39:551–557</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(70)90613-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Dodds WJ (1978) Platelet function in animals: species specificities. In: DeGaetano G, Garattini S (eds) Platelets: A multidisciplinary approach. Raven Press, New York, pp 45–59</span>
</li>
<li>
<span class="authors">Droller MJ (1976) Thrombin-induced platelet prostaglandin production and a possible intrinsic modulation of platelet function. Scand J Haematol 17:167–178</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1600-0609.1976.tb01172.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Droller MJ, Wolfe SM (1972) Thrombin induced increase in intracellular cyclic 3′,5′adenosine monophosphate in human platelets. J Clin Invest 51:3094–3103</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI107136" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Egorava VA, Belyaeva ZN, Blinova MN (1978) Activity of adenyl cyclase from platelets in some blood systemic impairments. Vopr Med Khim 24:28</span>
</li>
<li>
<span class="authors">Feinstein MB, Rodan GA, Cutler LS (1981) Cyclic AMP and calcium in platelet function. In: Gordon JL (ed) Platelets in biology and pathology, vol 2. Elsevier/North Holland, Amsterdam, pp 437–472</span>
</li>
<li>
<span class="authors">Fitzpatrick FA, Gorman RR (1979) Regulatory role of cyclic adenosine 3′,5′-monophosphate on platelet cyclo oxygenase and platelet function. Biochim Biophys Acta 582:44–58</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(79)90287-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Fox JEB, Say AK, Haslam RJ (1979) Subcellular distribution of the different platelet proteins phosphorylated on exposure to ionophore A 23187 or to prostaglandin E<sub class="a-plus-plus">1</sub>. Possible role of a membrane phosphopolypeptide in the regulation of calcium ion transport. Biochem J 184:651–661</span>
</li>
<li>
<span class="authors">Gear ARL, Schneider W (1975) Control of platelet glycogenosis by calcium. Biochim Biophys Acta 392:111–120</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(75)90171-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Gerrard JM, Peller JD, Krick TP, White JG (1977) Cyclic AMP and platelet prostaglandin synthesis. Prostaglandins 14:39–50</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(77)90155-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Glass DB, Frey W 2nd, Carr DW, Goldberg ND (1977 a) Stimulation of human platelet guanylate cyclase by fatty acids. J Biol Chem 252:1279–1285</span>
</li>
<li>
<span class="authors">Glass DB, Gerrard JM, Townsend D, Carr DW, White JG, Goldberg ND (1977 b) The involvement of prostaglandin endoperoxide formation in the elevation of cyclic GMP levels during platelet aggregation. J Cyclic Nucleotide Res 3:37–44</span>
</li>
<li>
<span class="authors">Goldberg ND, Haddox MK, Nicol SE, Glass DB, Sanford CH, Kuehl FA Jr, Stensen RE (1975) Biologic regulation through opposing influences of cyclic GMP and cyclic AMP: the Yin Yang hypothesis. Adv Cyclic Nucleotide Res 5:307–330</span>
</li>
<li>
<span class="authors">Gorman RR (1974) Specific PGE<sub class="a-plus-plus">1</sub> and PGE<sub class="a-plus-plus">2</sub> binding sites on platelet membranes. Prostaglandins 6:542</span>
<a class="external" href="http://dx.doi.org/10.1016/S0090-6980(74)80066-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Gorman RR (1975) Prostaglandin endoperoxides: possible new regulators of cyclic nucleotide metabolism. J Cyclic Nucleotide Res 1:1–9</span>
</li>
<li>
<span class="authors">Gorman RR (1979) Modulation of human platelet function by prostacyclin and thromboxane B2. Fed Proc 38:83–87</span>
</li>
<li>
<span class="authors">Gorman RR, Hamberg M, Samuelsson B (1976) Antagonism of the prostaglandin endoperoxide inhibition of hormone-stimulated a denylate cyclase by guanosine triphosphate and 5′guanylylimmidodiphosphate. Biochim Biophys Acta 444:596–603</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(76)90403-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Gorman RR, Bunting S, Miller O (1977) Modulation of human platelet adenylate cyclase by prostacyclin. Prostaglandins 13:377–388</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(77)90018-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Gorman RR, Wierenga W, Miller OV (1979) Independence of the cyclic AMP-lowering activity of thromboxane A<sub class="a-plus-plus">2</sub> from the platelet release reaction. Biochim Biophys Acta 572:95–104</span>
</li>
<li>
<span class="authors">Grant JA, Scrutton MC (1979) Novel alpha<sub class="a-plus-plus">2</sub>-adrenoceptors primarily responsible for inducing human platelet aggregation. Nature 277:659–661</span>
<a class="external" href="http://dx.doi.org/10.1038/277659a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Grant JA, Scrutton MC (1980) Interactions of selective <em class="a-plus-plus">α</em>-adrenoceptor agonists and antagonists with human and rabbit platelets. Br J Pharmacol 71:121–124</span>
</li>
<li>
<span class="authors">Grette K (1963) Relaxing factor in extracts of human platelets and its function in the cells. Nature 198:488–489</span>
<a class="external" href="http://dx.doi.org/10.1038/198488a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Gryglewski RJ, Szczeklik A, Krysztof B (1975) Morphine antagonises prostaglandin Elmediated inhibition of human platelet aggregation. Nature 256:5–57</span>
<a class="external" href="http://dx.doi.org/10.1038/256056a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Halushka PV, Lurie D, Colwell JA (1977) Increased synthesis of prostaglandin E-like material by platelets from patients with diabetes melitus. N Engl J Med 297:1306–1310</span>
<a class="external" href="http://dx.doi.org/10.1056/NEJM197712152972402" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hamet P, Coquil JF (1978) Cyclic GMP binding and cyclic GMP phosphodiesterase in rat platelets. J Cyclic Nucleotide Res 4:281–290</span>
</li>
<li>
<span class="authors">Hamet P, Fraysse J, Franks DJ (1978) Cyclic nucleotides and aggregation in platelets of spontaneously hypertensive rats. Circ Res 43:583–591</span>
</li>
<li>
<span class="authors">Harris DN, Asaad MM, Phillips MB, Goldenberg HJ, Antonaccio MJ (1979) Inhibition of adenylate cyclase in human blood platelets by 9-substituted adenine derivatives. J Cyclic Nucleotide Res 5:125–134</span>
</li>
<li>
<span class="authors">Harwood JP, Moskowitz J, Krishna GG (1972) Dynamic interaction of prostaglandin and norepinephrine in the formation of adenosine 3′5′monophosphate in human and rabbit platelets. Biochim Biophys Acta 261:444–456</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(72)90069-4" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hashimoto S, Shibata S, Kobayashi B (1975) Dependence of platelet adenylate cyclase system on oxidative phosphorylation. Thromb Diath Haemorrh 34:42–49</span>
</li>
<li>
<span class="authors">Haslam RJ (1973) Interactions of the pharmacological receptors of blood platelets with adenylate cyclase. Ser Haematol 6:333–350</span>
</li>
<li>
<span class="authors">Haslam RJ (1975) Role of cyclic nucleotides in platelet function. Ciba Found Symp 35:121–151</span>
</li>
<li>
<span class="authors">Haslam RJ (1978) Cyclic nucleotides in platelet function. In: Day HJ, Holmsen H, Zucker MB (eds) Platelet function testing. DHEW Publication (NIH) 78–1087, pp 487–503</span>
</li>
<li>
<span class="authors">Haslam RJ, Cusack NJ (1981) Blood platelet receptors for ADP and adenosine. In: Burnstock G (ed) Receptors and recognition, series B, vol 9: Purinergic receptors. Chapman & Hall, London</span>
</li>
<li>
<span class="authors">Haslam RJ, Lynham J (1972) Activation and inhibition of blood platelet adenylate cyclase by adenosine or by 2-chloroadenosine. Life Sci 11(II): 1143–1154</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(72)90269-X" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Haslam RJ, Lynham J (1977) Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule constituents. I. Effects of different aggregating agents. Biochem Biophys Res Commun 77:714–722</span>
<a class="external" href="http://dx.doi.org/10.1016/S0006-291X(77)80037-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Haslam RJ, Lynham J (1978) Relationship between phosphorylation of blood platelet proteins and secretion of platelet granule contents. II. Effects of different inhibitors. Thromb Res 12:619–628</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(78)90251-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Haslam RJ, McGlenaghan MD (1974) Effects of collagen and of aspirin on the concentration of guanosine 3′:5′-cyclic monophosphate in human blood platelets: measurement by a prelabelling technique. Biochem J 138:317–320</span>
</li>
<li>
<span class="authors">Haslam RJ, McGlenaghan MD (1981) Measurement of circulating prostacyclin. Nature 292:364–366</span>
<a class="external" href="http://dx.doi.org/10.1038/292364a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Haslam RJ, Rosson GM (1975) Effects of adenosine on levels of adenosine cyclic 3′,5′-monophosphate in human blood platelets in relation to adenosine incorporation and platelet aggregation. Mol Pharmacol 11:528–544</span>
</li>
<li>
<span class="authors">Haslam RJ, Say A (1975) Effects of acetylcholine and carbachol on cyclic GMP levels in dog platelets ion relation to platelet function: role of extracellular Ca<sup class="a-plus-plus">2+</sup> ions. Fed Proc 34:231</span>
</li>
<li>
<span class="authors">Haslam RJ, Taylor A (1971 a) Effects of catecholamines on the formation of adenosine 3′:5′-cyclic monophosphate in human blood platelets. Biochem J 125:377–379</span>
</li>
<li>
<span class="authors">Haslam RJ, Taylor A (1971 b) Role of cyclic 3′5′ adenosine monophosphate on platelet aggregation. In: Caen JP (ed) Platelet aggregation. Masson, Paris, pp 85–93</span>
</li>
<li>
<span class="authors">Haslam RJ, Davidson MML, McClenagham MD (1975) Cytochalasin B, the blood platelet release reaction and cyclic GMP. Nature 253:455–457</span>
<a class="external" href="http://dx.doi.org/10.1038/253455a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Haslam RJ, McGlenaghan MD, Adams A (1975) Depression of cyclic GMP levels in blood platelets by acetylsalicylic acid (ASA) and related drugs. Adv Cyclic Nucleotide Res 5:821</span>
</li>
<li>
<span class="authors">Haslam RJ, Davidson MML, Davies T, Lynham JA, McGlenaghan MD (1978 a) Regulation of blood platelet function by cyclic nucleotides. Adv Cyclic Nucleotide Res 9:533–552</span>
</li>
<li>
<span class="authors">Haslam RJ, Davidson MML, Desjardins JV (1978 b) Inhibition of adenylate cyclase by adenosine analogues in preparations of broken and intact human platelets. Evidence for the unidirectional control of platelet function by cyclic AMP. Biochem J 176:83–95</span>
</li>
<li>
<span class="authors">Haslam RJ, Davidson MML, Desjardins JV, Fox J, Lynham J (1978 c) Factors affecting the formation and actions of cyclic AMP in blood platelets. Adv Pharmacol Ther 4:75–85</span>
</li>
<li>
<span class="authors">Haslam RJ, Davidson MML, Fox J, Lynham J (1978 d) Cyclic nucleotides in platelet function. Thromb Haemost 40:232–240</span>
</li>
<li>
<span class="authors">Haslam RJ, Davidson MML, Lemmex BWG, Desjardins JV, McCarry BE (1979 a) Adenosine receptors of the blood platelet: interactions with adenylate cyclase. In: Baer HP, Drummond GI (eds) Physiological and regulatory functions of adenosine and adenine nucleotides. Raven Press, New York, pp 189–204</span>
</li>
<li>
<span class="authors">Haslam RJ, Lynham J, Fox J (1979 b) Effects of collagen, ionophore A 23187 and prostaglandin E1 on the phosphorylation of specific proteins in blood platelets. Biochem J 178:397–406</span>
</li>
<li>
<span class="authors">Haslam RJ, Salama SE, Fox JEB, Lynham JA, Davidson MML (1980) Roles of cyclic nucleotides and of protein phosphorylation in the regulation of platelet function. In: Rotman A, Meyer FA, Gitler C, Silberberg A (eds) Platelets: Cellular Response Mechanism and their Biological Significance. Wiley, Chichester, pp 213–231</span>
</li>
<li>
<span class="authors">Hathaway DR, Eaton CR, Adelstein RS (1981) Regulation of human platelet myosin light chain kinase by the catalytic subunit of cyclic AMP-dependent protein kinase. Nature 291:252–254</span>
<a class="external" href="http://dx.doi.org/10.1038/291252a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hidaka H, Asano T (1976a) Human Blood platelet 3′:5′-cyclic nucleotides phosphodiesterase. Isolation of low Km and high Km phosphodiesterase. Biochim Biophys Acta 429:485–497</span>
</li>
<li>
<span class="authors">Hidaka H, Asano T (1976 b) Platelet cyclic 3′:5′-nucleotide phosphodiesterase released by thrombin and calcium ionophore. J Biol Chem 251:7508–7516</span>
</li>
<li>
<span class="authors">Hidaka H, Asano T (1977) Stimulation of human platelet guanylate cyclase by unsaturated fatty acid peroxides. Proc Natl Acad Sci USA 74:3657–3661</span>
<a class="external" href="http://dx.doi.org/10.1073/pnas.74.9.3657" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hidaka H, Asano T, Shibuya M, Shimamoto T (1974) Cyclic GMP phosphodiesterase of human blood platelets and its inhibitors. Thromb Diath Haemorrh [Suppl] 60:321–327</span>
</li>
<li>
<span class="authors">Hirose S, Asano T, Hidaka H (1978) Effects of unsaturated fatty acids on separated forms of human platelet cyclic nucleotide phosphodiesterase. Thromb Res 12:701–706</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(78)90262-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hoffman BB, LeDean A, Wood CL, Schocken DD, Lefkowitz RJ (1979) Alpha-adrenergic receptor subtypes: quantitative assessment by ligand binding. Life Sci 24:1739–1746</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(79)90061-4" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hoffman BB, Michel T, Mulliken-Kilpatrick D, Lefkowitz RJ, Tolbert MEM, Filman H, Fain JN (1980) Agonist versus antagonist binding to a adrenergic receptors. Proc Natl Acad Sci USA 77:4569–4573</span>
<a class="external" href="http://dx.doi.org/10.1073/pnas.77.8.4569" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Holmsen H (1965) Incorporation of <sup class="a-plus-plus">32</sup>P into platelet acid soluble organophosphates and their chromatographic identification. Scand J Clin Lab Invest 17:230–242</span>
</li>
<li>
<span class="authors">Holmsen H, Smith JB, Daniel JL, Holme S, Bills TK (1979) Platelet biochemistry. In: Schmidt RM (ed) CRC Handbook Series in Clinical Laboratory Science, vol 1. pp 273–312</span>
</li>
<li>
<span class="authors">Honegger H, Trimmer R, Bally P (1975) Rise and fall of the cAMP content in human blood platelets after stimulation of their adenyl cyclase with prostaglandin E<sub class="a-plus-plus">1</sub>. Experientia 31:729</span>
</li>
<li>
<span class="authors">Horch U, Kadatz R, Kopitar Z, Weisenberger H (1970) Pharmacology of dipyridamole and its derivatives. Thromb Diath Haemorh [Suppl] 42:253–266</span>
</li>
<li>
<span class="authors">Horlington M, Watson PA (1970) Inhibition of 3′5′ cyclic AMP phosphodiesterase by some platelet aggregation inhibitors. Biochem Pharmacol 19:955–956</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-2952(70)90262-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hornstra G, Haddeman E, Don JA (1979) Blood platelets do not provide endoperoxides for vascular prostacyclin synthesis. Nature 279:66–68</span>
<a class="external" href="http://dx.doi.org/10.1038/279066a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Hsu CY, Knapp DR, Halushka PV (1979) The effects of alpha adrenergic agents on human platelet aggregation. J Pharmacol Exp Ther 28:36–37</span>
</li>
<li>
<span class="authors">Hughes RJ, Insel PA (1980) Regulation of cyclic AMP levels in human platelets. Fed Proc 39:424</span>
</li>
<li>
<span class="authors">Insel PA, Nirenberg P, Turnbull J, Shattil SJ (1978) Relationships between membrane cholesterol, <em class="a-plus-plus">α</em>-adrenergic receptors, and platelet function. Biochemistry 17:5269–5274</span>
<a class="external" href="http://dx.doi.org/10.1021/bi00617a029" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Jakobs KH (1978 a) Inhibition of platelet adenylate cyclase by <em class="a-plus-plus">α</em>-adrenergic agents. In: Falco G, Paoletti R (eds) Molecular biology and pharmacology of cyclic nucleotides: Proceedings of the NATO Advanced Study Institute on Cyclic Nucleotides. Elsevier/North Holland, New York</span>
</li>
<li>
<span class="authors">Jakobs KH (1978 b) Synthetic <em class="a-plus-plus">α</em>-adrenergic agonists are potent <em class="a-plus-plus">α</em>-adrenergic blockers in human platelets. Nature 274:819–820</span>
<a class="external" href="http://dx.doi.org/10.1038/274819a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Jakobs KH (1978 c) GTP-dependent inhibition of platelet adenylate cyclase by a adrenergic agents. In: Krause EG et al. (ed) Cyclic nucleotides and protein phosphorylation in cell regulation: Proc 12th FEBS Meeting. Pergamon, Oxford, pp 11–19</span>
</li>
<li>
<span class="authors">Jakobs KH, Rauschek R (1978) (<sup class="a-plus-plus">3</sup>H) Dihydroergonine binding to <em class="a-plus-plus">α</em>-adrenergic receptors in human platelets. Klin Wochenschr [Suppl 1] 56:139–145</span>
<a class="external" href="http://dx.doi.org/10.1007/BF01477465" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Jakobs KH, Schultz G (1979) Different inhibitory effects of adrenaline on platelet adenylate cyclase E.C. 4.6.1.1 in the presence of GTP plus cholera toxin and stable GTP analogs. Naunyn Schmiedebergs Arch Pharmacol 310:121–128</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00500276" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Jakobs KH, Bohme E, Mocikat S (1974) Cyclic GMP formation in human platelets. Naunyn Schmiedebergs Arch Pharmacol [Suppl] 282:R 40</span>
</li>
<li>
<span class="authors">Jakobs KH, Saur W, Schultz G (1976) Reduction of adenylate cyclase activity of human platelets by the alpha adrenergic component of epinephrine. J Cyclic Nucleotide Res 2:381–392</span>
</li>
<li>
<span class="authors">Jakobs KH, Sauer W, Schultz G (1978 a) Metal and metal-ATP interactions with human platelet adenylate cyclase: effects of alpha adrenergic inhibition. Mol Pharmacol 14:1073–1078</span>
</li>
<li>
<span class="authors">Jakobs KH, Saur W, Schultz G (1978 b) Characterisation of <em class="a-plus-plus">α</em>- and <em class="a-plus-plus">β</em>-adrenergic receptors linked to human platelet adenylate cyclase. Naunyn Schmiedebergs Arch Pharmacol 302:285–291</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00508297" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Jakobs KH, Saur W, Schultz G (1978 c) Inhibition of platelet adenylate cyclase by epinephrine requires GTP. FEBS Lett 85:167–170</span>
<a class="external" href="http://dx.doi.org/10.1016/0014-5793(78)81272-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Jakobs KH, Saur W, Johnson RA (1979) Regulation of platelet adenylate cyclase by adenosine. Biochim Biophys Acta 583:409–421</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(79)90058-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Johnson RA, Saur W, Jakobs KH (1979) Effects of prostaglandin E<sub class="a-plus-plus">1</sub> and adenosine on metal and metal-ATP kinetics of platelet adenylate cyclase. J Biol Chem 234:1095–1101</span>
</li>
<li>
<span class="authors">Jorgensen KA, Dyerberg J, Stofferson E (1979) PGI<sub class="a-plus-plus">2</sub> and the effect of phosphodiesterase inhibitors on platelet function. Pharmacol Res Commun 11:605–615</span>
<a class="external" href="http://dx.doi.org/10.1016/S0031-6989(79)80032-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Kafka MS, Tallman JF, Smith CC, Costa JL (1977) Alpha adrenergic receptors on human platelets. Life Sci 21:1429–1438</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(77)90197-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Kafka MS, VanKammen DP, Bunney WE Jr (1979) Reduced cyclic AMP production in the blood platelets from schizophrenic patients. Am J Psychiatry 136:685–687</span>
</li>
<li>
<span class="authors">Kariya T, Kume S, Tanabe A, Kaneko T, Yamanaka M, Oda T (1979) Effects of PGE<sub class="a-plus-plus">1</sub> on protein kinase activity and endogenous phosphorylation of intact human platelets. Biochem Pharmacol 28:2747–2751</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-2952(79)90558-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Kaser-Glanzmann R, Jacabova M, George JN, Luscher EF (1977) Stimulation of calcium uptake in platelet membrane vesicles by adenosine 3′,5′-cyclic monophosphate and protein kinase. Biochim Biophys Acta 466:429–440</span>
<a class="external" href="http://dx.doi.org/10.1016/0005-2736(77)90336-4" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Kaulen HD, Gross R (1964) Purification and properties of a soluble cyclic AMP dependent protein kinase of human platelets. Hoppe Seylers Z Physiol Chem 355:471–480</span>
<a class="external" href="http://dx.doi.org/10.1515/bchm2.1974.355.1.471" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Kaywin P, McDonough M, Insel PA, Shattil SJ (1978) Platelet function in essential thrombocythemia. N Engl J Med 299:505–509</span>
<a class="external" href="http://dx.doi.org/10.1056/NEJM197809072991002" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Kloeze J (1966) Influence of prostaglandins on platelet aggregation and platelet adhesiveness. In: Bergstrom S, Samuelsson B (eds) Proc II Nobel Symposium Interscience, London, pp 241–252</span>
</li>
<li>
<span class="authors">Kloeze J (1969) Relationship between chemical structure and platelet aggregation activity of prostaglandins. Biochim Biophys Acta 187:285–292</span>
</li>
<li>
<span class="authors">Klysner R, Geisler A, Hansen KW, Stahlskov P, Norn S (1980) Histamine H2 receptor-mediated cyclic AMP formation in human platelets. Acta Pharmacol Toxicol 47:1–4</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1600-0773.1980.tb01650.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Krishna G, Harwood JP, Barber AJ, Jamieson GA (1972) Requirement for guanosine triphosphate in the prostaglandin activation of adenylate cyclase of platelet membranes. J Biol Chem 247:2253–2254</span>
</li>
<li>
<span class="authors">Lagard M, Dechavanne M (1975) Etude de taux d’AMP cyclique (AMPc) et de Prostaglandine E<sub class="a-plus-plus">1</sub> (PGE<sub class="a-plus-plus">1</sub> dans les plaquettes sanguines, avant et au cours des thromboses veineuses post-operatoires. Biomedicine 23:374–377</span>
</li>
<li>
<span class="authors">Lagard M, Dechavanne M, Rigaud M, Durand J (1979) Basal level of human platelet prostaglandins. PGE<sub class="a-plus-plus">1</sub> is more elevated than PGE<sub class="a-plus-plus">2</sub>. Prostaglandins 17:685–705</span>
<a class="external" href="http://dx.doi.org/10.1016/S0090-6980(79)80041-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Lammernant-Guillemare E, Corcelle-Cerf F, Lammernant J (1977) Cyclic 3′,5′-adenosine monophosphate level and adenylate cyclase activity in human blood platelets during storage in ACD solution. Blut 34:329–330</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00996209" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Lapetina EG, Schmitges CJ, Chandrabose K, Cuatrecasas P (1977) Cyclic adenosine 3′,5′-monophosphate and prostacyclin inhibit membrane phospholipase activity in platelets. Biochem Biophys Res Commun 76:828–835</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(77)91575-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Lasch P, Jakobs KH (1979) Agonistic and antagonistic effects of various <em class="a-plus-plus">α</em>-adrenergic agonists in human platelets. Naunyn Schmiedebergs Arch Pharmacol 306:119–125</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00498981" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Lindgren JA, Claesson HE, Kindahl H, Hammerstrom S (1979) Effects of adenosine 3′:5′-monophosphate and platelet aggregation on thromboxane biosynthesis in human platelets. FEBS Lett 98:247–250</span>
<a class="external" href="http://dx.doi.org/10.1016/0014-5793(79)80192-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Londos C, Wolff J (1977) Two distinct adenosine sensitive sites on adenylate cyclase. Proc Natl Acad Sci USA 74:5482–5486</span>
<a class="external" href="http://dx.doi.org/10.1073/pnas.74.12.5482" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Longnecker GL, Koaciewicz LJ, Palmer SJ, Palmer GC (1980) Prostaglandin stimulation of canine platelet adenylate cyclase. Thromb Res 19:119–124</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(80)90410-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Lyons RM, Stanford N, Majerus PW (1975) Thrombin-induced protein phosphorylation in human platelets. J Clin Invest 56:924–936</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI108172" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Macfarlane DE, Mills DCB (1975) The effects of ATP on platelets: evidence against the central role of released ADP in primary aggregation. Blood 46:309–320</span>
</li>
<li>
<span class="authors">Macfarlane DE, Mills DCB (1977) The number and nature of ADP receptors on human blood platelets determined with a photoaffmity label. Thromb Haemost 38:241</span>
</li>
<li>
<span class="authors">Macfarlane DE, Mills DCB (1981) Inhibition by ADP of prostaglandin induced accumulation of cyclic AMP in intact human platelets. J Cyclic Nucleotide Res 7:1–11</span>
</li>
<li>
<span class="authors">Macfarlane DE, Stump DC (1981) Selective binding of <sup class="a-plus-plus">3</sup>H yohimbine to the <em class="a-plus-plus">α</em>
<sub class="a-plus-plus">2</sub>-receptor of intact platelets — comparison with <sup class="a-plus-plus">3</sup>H dihydroergocryptine binding. Thromb Haemost 46:24</span>
</li>
<li>
<span class="authors">Macfarlane DE, Srivastava PC, Mills DCB (1979) 2 Methylthioadenosine 5′-diphosphate, a high affinity probe for ADP receptors on the human platelet. Thromb Haemost 42:182</span>
</li>
<li>
<span class="authors">MacIntyre DE (1981) Platelet prostaglandin receptors. In: Gordon JL (ed) Platelets in biology and pathology, vol 2. Elsevier/North Holland, Amsterdam pp 211–247</span>
</li>
<li>
<span class="authors">Maclntyre DE, Gordon JL (1975) Calcium-dependent stimulation of platelet aggregation by PGE<sub class="a-plus-plus">2</sub>. Nature 258:337–339</span>
<a class="external" href="http://dx.doi.org/10.1038/258337a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">MacIntyre DE, Gordon JL (1977) Discrimination between platelet prostaglandin receptors with a specific antagonist of bisenoic prostaglandins. Thromb Res 11:705–713</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(77)90099-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Maguire HM, Penglis-Caredes F, Gough GR (1974) Effects of the 3′5′-cyclic phosphates of 2-methylthioadenosine, 2-chloroadenosine and adenosine on platelet aggregation. Experientia 30:922–92454</span>
<a class="external" href="http://dx.doi.org/10.1007/BF01938364" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Malmsten C, Granstrom E, Samuelsson B (1976) Cyclic AMP inhibits synthesis of prostaglandin endoperoxides (PGG<sub class="a-plus-plus">2</sub>) in human platelets. Biochim Biophys Acta 68:569–576</span>
</li>
<li>
<span class="authors">Mannucci PM, Pareti FI (1974) Platelet functions after intravenous administration in man of cyclic AMP and related drugs. J Lab Clin Med 84:828–838</span>
</li>
<li>
<span class="authors">Marcus AJ, Zucker MB (1965) The physiology of blood platelets. Grune & Stratton, New York</span>
</li>
<li>
<span class="authors">Markwardt F, Hoffmann A (1970) Effects of papaverine derivatives on cyclic AMP phosphodiesterase of human platelets. Biochem Pharmacol 19:2519–2520</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-2952(70)90279-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Markwardt F, Barthel W, Glusa E, Hoffmann A (1967) Untersuchungen über den Einfluß von Papaverin auf Reaktionen der Blutplättchen. Naunyn Schmiedebergs Arch Pharmacol 257:420–431</span>
</li>
<li>
<span class="authors">Marquis NR, Vigdahl RL, Tavormina PA (1969) Platelet aggregation 1. Regulation by cyclic AMP and prostaglandin E<sub class="a-plus-plus">1</sub>. Biochem Biophys Res Commun 36:965–972</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(69)90298-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Marquis NR, Becker JA, Vigdahl RL (1970) Platelet aggregation 3. An epinephrine induced decrease in cyclic AMP synthesis. Biochem Biophys Res Commun 79:783–789</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(70)90391-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">McDonald JW (1970) Lymphocyte and platelet adenylate cyclase. Can J Biochem 49:316–319</span>
</li>
<li>
<span class="authors">McDonald JW, Stuart RK (1973) Regulation of cyclic AMP levels and aggregation in human platelets by prostaglandin E<sub class="a-plus-plus">1</sub>. J Lab Clin Med 81:838–849</span>
</li>
<li>
<span class="authors">McDonald JW, Stuart RK (1974) Interaction of prostaglandins E<sub class="a-plus-plus">1</sub> and E<sub class="a-plus-plus">2</sub> in regulation of cyclic AMP and aggregation in human platelets: evidence for a common prostaglandin receptor. J Lab Clin Med 84:111–121</span>
</li>
<li>
<span class="authors">McElroy FA, Philp RB (1976) Relative potencies of dipyridamole and related agents as inhibitors of cyclic nucleotide phosphodiesterases: possible explanation of mechanism of inhibition of platelet function. Life Sci 17:1479–1490</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(75)90170-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">McMillan R, Bakich MJ, Yelenofsky RJ (1979) The adrenaline binding site on human platelets. Br J Haematol 41:597–604</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1365-2141.1979.tb05896.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mehta P, Mehta J (1980) Platelet function studies in coronary heart disease VIII. Decreased platelet sensitivity to prostacyclin in patients with myocardial ischaemia. Thromb Res 18:273–277</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(80)90193-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mellwig KP, Jakobs KH (1980) Inhibition of platelet adenylate cyclase by ADP. Thromb Res 18:7–17</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(80)90166-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Michel H, Caen JP, Born GVR, Miller R, D’Auriac GA, Meyer P (1976) Relation between the inhibition of aggregation and the concentration of cAMP in human and rat platelets. Br J Haematol 33:27–38</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1365-2141.1976.tb00969.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Michel T, Hoffman BB, Lefkowitz RJ (1980) Differential regulation of the <em class="a-plus-plus">α</em>-adrenergic receptor by Na and guanine nucleotides. Nature 288:709–711</span>
<a class="external" href="http://dx.doi.org/10.1038/288709a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Miller OV, Gorman RR (1976) Modulation of platelet cyclic nucleotide content by PGE<sub class="a-plus-plus">1</sub> and the prostaglandin endoperoxide PGG<sub class="a-plus-plus">2</sub>. J Cyclic Nucleotide Res 2:79–87</span>
</li>
<li>
<span class="authors">Miller OV, Gorman RR (1979) Evidence for distinct prostaglandin I<sub class="a-plus-plus">2</sub> and D<sub class="a-plus-plus">2</sub> receptors in human platelets. J Pharmacol Exp Ther 210:134–140</span>
</li>
<li>
<span class="authors">Miller OV, Johnson RA, Gorman RR (1977) Inhibition of PGE<sub class="a-plus-plus">1</sub>-stimulated cyclic AMP accumulation in human platelets by thromboxane A<sub class="a-plus-plus">2</sub>. Prostaglandins 13:599–609</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(77)90231-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mills DCB (1974) Factors influencing the adenylate cyclase system in human platelets. In: Sherry S, Scriabine A (eds) Platelets and thrombosis. University Park Press, Baltimore, pp 45–67</span>
</li>
<li>
<span class="authors">Mills DCB (1975) Initial biochemical responses of platelets to stimulation. Ciba Found Symp 35:153–167</span>
</li>
<li>
<span class="authors">Mills DCB (1979) The regulation of adenylate cyclase activity in human platelets. In: Mann KG, Taylor FB (eds) The regulation of coagulation. Elsevier/North Holland, New York, pp 419–427</span>
</li>
<li>
<span class="authors">Mills DCB, Macfarlane DE (1974) Stimulation of human platelet adenylate cyclase by prostaglandin D<sub class="a-plus-plus">2</sub>. Thromb Res 5:401–412</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(74)90176-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mills DCB, Macfarlane DE (1975) Cytochalasins: effects on platelet aggregation, adenylate cyclase and membrane transport processes. Thromb Diath Haemorrh 34:917</span>
</li>
<li>
<span class="authors">Mills DCB, Macfarlane DE (1976) Platelet receptors. In: Gordon JL (ed) Platelets in biology and pathology. Elsevier, Amsterdam, pp 159–202</span>
</li>
<li>
<span class="authors">Mills DCB, Macfarlane DE (1977) Prostaglandins and platelet adenylate cyclase. In: Silver MJ, Smith JB, Kocsis JJ (eds) Prostaglandins in hematology. Spectrum, Fellbach, pp 219–233</span>
</li>
<li>
<span class="authors">Mills DCB, Macfarlane DE (1980) An inhibitory effect of prostaglandin E<sub class="a-plus-plus">1</sub> (PGE<sub class="a-plus-plus">1</sub>) and prostaglandin-like aggregating agents on platelet cyclic AMP accumulation, Proc 18th Int. Congr. Hematol. Montreal</span>
</li>
<li>
<span class="authors">Mills DCB, Roberts GCK (1967 a) Membrane active drugs and the aggregation of human blood platelets. Nature 213:35–38</span>
<a class="external" href="http://dx.doi.org/10.1038/213035a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mills DCB, Roberts GCK (1967) Effects of adrenaline on human blood platelets. J Physiol 193:443–453</span>
</li>
<li>
<span class="authors">Mills DCB, Smith JB (1971) The influence on platelet aggregation of drugs that affect the accumulation of adenosine 3′:5′-cyclic monophosphate in platelets. Biochem J 121:185–196</span>
</li>
<li>
<span class="authors">Mills DCB, Smith JB (1972) The control of platelet responsiveness by agents that influence cyclic AMP metabolism. Ann NY Acad Sci 201:391–399</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1749-6632.1972.tb16312.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mills DCB, Thomas DP (1969) Blood platelet nucleotides in man and other species. Nature 222:991–992</span>
<a class="external" href="http://dx.doi.org/10.1038/222991a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mills DCB, Robb IA, Roberts GCK (1968) The release of nucleotides, 5-hydroxytryptamine and enzymes from human blood platelets during aggregation. J Physiol 195:715–729</span>
</li>
<li>
<span class="authors">Mills DCB, Smith JB, Born GVR (1970) Pharmacology of platelet aggregation inhibition. In: Mammen EF, Anderson GF, Barnhart MI (eds) Platelet adhesion and aggregation in thrombosis: Countermeasures. Schattauer, Stuttgart, pp 165–184</span>
</li>
<li>
<span class="authors">Minkes M, Stanford N, Chi MMY, Roth GJ, Raz A, Needleman P, Majerus PW (1977) Cyclic adenosine 3′5′-monophosphate inhibits availability of arachidonate to prostaglandin synthetase in human platelet suspensions. J Clin Invest 59:449–454</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI108659" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Mitchell JRA, Sharp AA (1964) Platelet clumping in vitro. Br J Haematol 10:78–93</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1365-2141.1964.tb00681.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Moake JL, Cimo PL, Widner P, Peterson DM, Gum JR (1977) Effects of prostaglandins, derivatives of cyclic 3′:5′-AMP, theophylline, cholinergic agents and colchicine on clot retraction in dilute platelet rich plasma and gel-separated platelet test systems. Thromb Diath Haemorrh 38:420–428</span>
</li>
<li>
<span class="authors">Moncada S, Korbut R (1978) Dipyridamole and other phosphodiesterase inhibitors act as antithrombotic agents by potentiating endogenous prostacyclin. Lancet I:1286–1287</span>
<a class="external" href="http://dx.doi.org/10.1016/S0140-6736(78)91269-2" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Moncada S, Vane JR (1979) Pharmacology and endogenous roles of prostaglandin endoperoxides, thromboxanes and prostacyclin. Pharmacol Rev 30:293–331</span>
</li>
<li>
<span class="authors">Moskowitz J, Harwood JP, Reid WD, Krishna G (1971) The interaction of norepinephrine and prostaglandin E<sub class="a-plus-plus">1</sub> on the adenylate cyclase of human and rabbit blood platelets. Biochim Biophys Acta 230:279–285</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(71)90214-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Motulsky HJ, Shattil SA, Insel PA (1980) Characterization of <em class="a-plus-plus">α</em>
<sup class="a-plus-plus">2</sup>-adrenergic receptors on human platelets using [<sup class="a-plus-plus">3</sup>H]yohimbine. Biochem Biophys Res Commun 97:1562–1570</span>
<a class="external" href="http://dx.doi.org/10.1016/S0006-291X(80)80044-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Murer EH (1971a) Compounds known to effect the adenosine monophosphate level in blood platelets: effects on thrombin-induced clot retraction and platelet release. Biochim Biophys Acta 237:310–315</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(71)90323-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Murer EH (1971b) Effect of prostaglandin E<sub class="a-plus-plus">1</sub> on clot retraction. Nature 229:112–113</span>
<a class="external" href="http://dx.doi.org/10.1038/229112a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Murphy D, Donnelly C, Moskowitz J (1973) Inhibition by lithium of PGE<sub class="a-plus-plus">1</sub> and norepinephrine effects on cyclic AMP production in human platelets. Clin Pharmacol Ther 14:810–814</span>
</li>
<li>
<span class="authors">Mustard JF, Packham MA (1970) Factor influencing platelet function: adhesion, release and aggregation. Pharmacol Rev 22:97–187</span>
</li>
<li>
<span class="authors">Mustard JF, Kinlough-Rathbone RL, Packham M (1980) Prostaglandins and platelets. Annu Rev Med 31:89–96</span>
<a class="external" href="http://dx.doi.org/10.1146/annurev.me.31.020180.000513" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Needleman P, Wyche A, Raz A (1979) Platelet and blood vessel arachidonate metabolism and interactions. J Clin Invest 63:345–349</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI109309" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Newman KD, Williams LT, Bishopric NH, Lefkowitz RJ (1978) Identification of alpha-adrenergic receptors in human platelets by (<sup class="a-plus-plus">3</sup>H)dihydroergocryptine binding. J Clin Invest 61:395–402</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI108950" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Nishizawa EE, Miller WL, Gorman RR, Bundy GL, Svensson J, Hamberg M (1975) Prostaglandin D<sub class="a-plus-plus">2</sub> as a potential antithrombotic agent. Prostaglandins 9:109–121</span>
<a class="external" href="http://dx.doi.org/10.1016/S0090-6980(75)80122-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">O’Brien JR (1963) Some effects of adrenaline and antiadrenaline compounds on platelets in vitro and in vivo. Nature 200:763–764</span>
<a class="external" href="http://dx.doi.org/10.1038/200763a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Pandey GN, DeLeon-Jones FA, Inwang ET, Davies JM (1980) Effects of acute methadone withdrawal on prostaglandin E-stimulated <sup class="a-plus-plus">3</sup>H cyclic adenosine monophosphate accumulation in human platelets. J Lab Clin Med 27:607–611</span>
</li>
<li>
<span class="authors">Pareti FI, Carrera D, Mannucci L, Mannucci PM (1978) Effect on platelet functions of derivatives of cyclic nucleotides. Thromb Haemost 39:404–410</span>
</li>
<li>
<span class="authors">Patterson WD, Hardman JG, Sutherland EW (1975) Hydrolysis of guanosine and adenosine 3′,5′-monophosphate by rat blood. Biochim Biophys Acta 384:159–167</span>
</li>
<li>
<span class="authors">Pichard A-L, Kaplan JC (1975) Effect of N<sup class="a-plus-plus">6</sup>,2′0-dibutyryl cyclic AMP upon the interconvertible forms of cyclic AMP phosphodiesterase from human platelets. Biochem Biophys Res Commun 64:342–346</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(75)90259-4" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Pichard A-L, Hanoune J, Kaplan JC (1972) Human brain and platelet cyclic adenosine 3′,5′-monophosphate phosphodiesterases: different response to drugs. Biochim Biophys Acta 279:217–220</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(72)90258-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Pichard A-L, Hanoune J, Kaplan JC (1973) Multiple forms of cyclic AMP phosphodiesterase from human blood platelets 1. Kinetic and electrophoretic characterization of two molecular species. Biochim Biophys Acta 315:370–377</span>
</li>
<li>
<span class="authors">Rasmussen H, Goodman DBP (1977) Relationships between calcium and cyclic nucleotides in cell activation. Physiol Rev 57:421–509</span>
</li>
<li>
<span class="authors">Reches A, Eldor A, Vogel Z, Solomon Y (1980) Do human platelets have opiate receptors? Nature 288:382–383</span>
<a class="external" href="http://dx.doi.org/10.1038/288382a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Roberts JM, Goldfein RD, Tsuchiya AM, Insel PA (1979) Estrogen treatment decreases adrenergic binding sites on rabbit platelets. Endocrinology 104:722–728</span>
<a class="external" href="http://dx.doi.org/10.1210/endo-104-3-722" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Robison GA, Arnold A, Hartmann RC (1969) Divergent effects of epinephrine and prostaglandin E<sub class="a-plus-plus">1</sub> on the level of cyclic AMP in human blood platelets. Pharmacol Res Commun 1:325–332</span>
<a class="external" href="http://dx.doi.org/10.1016/S0031-6989(69)80047-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Robison GA, Cole B, Arnold A, Hartmann RC (1971) Effects of prostaglandins on function and cyclic AMP levels of human platelets. Ann NY Acad Sci 180:324–331</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1749-6632.1971.tb53200.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Roblee LS, Shepro D, Belamarich FA (1973) Calcium uptake and associated adenosine triphosphatase activity of isolated platelet membranes. J Gen Physiol 61:462–481</span>
<a class="external" href="http://dx.doi.org/10.1085/jgp.61.4.462" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Rodan GA, Feinstein MB (1976) Interrelationships between Ca<sup class="a-plus-plus">2+</sup> and adenylate and guanylate cyclases in the control of platelet secretion and aggregation. Proc Natl Acad Sci USA 73:1829–1833</span>
<a class="external" href="http://dx.doi.org/10.1073/pnas.73.6.1829" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Rotrosen J, Miller A, Mandio D, Traficante L, Gershon S (1978) Reduced PGE<sub class="a-plus-plus">1</sub> stimulated cyclic AMP accumulation in platelets from schizophrenics. Life Sci 23:1989–1996</span>
<a class="external" href="http://dx.doi.org/10.1016/0024-3205(78)90230-8" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Rozenberg MC, Walker CM (1973) The effect of pyrimidine compounds on the potentiation of adenosine inhibition of aggregation, on adenosine phosphorylation and on phosphodiesterase activity of blood platelets. Biochem J 24:409–418</span>
</li>
<li>
<span class="authors">Saba HI, Saba SR, Blackburn CA, Hartmann RC, Mason RG (1979) Heparin neutralization of PGI<sub class="a-plus-plus">2</sub>: effects upon platelets. Science 205:499–501</span>
<a class="external" href="http://dx.doi.org/10.1126/science.377493" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Salzman EW (1972) Cyclic AMP and platelet function. N Engl J Med 286:358–363</span>
<a class="external" href="http://dx.doi.org/10.1056/NEJM197202102860629" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Salzman EW (1973) Prostaglandins in the function of blood platelets. In: Baulieu E (ed) Les Prostaglandines. INSERM, Paris, pp. 331–343</span>
</li>
<li>
<span class="authors">Salzman EW (1977) Interrelation of prostaglandin endoperoxide PGG<sub class="a-plus-plus">2</sub> and cyclic 3′,5′-adenosine monophosphate in human blood platelets. Biochim Biophys Acta 499:48–60</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(77)90227-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Salzman EW (1978) Platelets, prostaglandins and cyclic nucleotides. In: DeGaetano G, Garrattini S (eds) Platelets: a multidisciplinary approach. Raven Press, New York, pp 227–238</span>
</li>
<li>
<span class="authors">Salzman EW, Levine L (1971) Cyclic 3′,5′-adenosine monophosphate in human blood platelets 2. Effect of N<sup class="a-plus-plus">6–</sup>2′o-dibutyryl cyclic 3′,5′-adenosine monophosphate on human platelet function. J Clin Invest 50:131–141</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI106467" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Salzman EW, Neri LL (1969) Cyclic 3′,5′-adenosine monophosphate in human blood platelets. Nature 224:609–610</span>
<a class="external" href="http://dx.doi.org/10.1038/224609a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Salzman EW, Weisenberger H (1972) Role of cyclic AMP in platelet function. Adv Cyclic Nucleotide Res 1:231–247</span>
</li>
<li>
<span class="authors">Salzman EW, Rubino EB, Sims RV (1970) Cyclic 3′,5′-adenosine monophosphate in human platelets 3. The role of cyclic AMP in platelet aggregation. Ser Haematol 3:100–113</span>
</li>
<li>
<span class="authors">Salzman EW, Lindon JN, Rodvien R (1976) Cyclic AMP in human blood platelets: relation to platelet prostaglandin synthesis induced by centrifugation or surface contact. J Cyclic Nucleotide Res 2:25–37</span>
</li>
<li>
<span class="authors">Salzman EW, MacIntyre DE, Steer ML, Gordon JL (1979) Effect on platelet activity of inhibition of adenylate cyclase. Thromb Res 13:1089–1101</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(78)90237-2" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Samuels CE, Robinson PG, Elliot RB (1975) Decreased inhibition of platelet aggregation by prostaglandin E<sub class="a-plus-plus">1</sub> in children with cystic fibrosis and their parents. Prostaglandins 10:617–621</span>
<a class="external" href="http://dx.doi.org/10.1016/S0090-6980(75)80008-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Schafer AI, Cooper B, O’Hara D, Handin RI (1979) Identification of platelet receptors for prostaglandin E<sub class="a-plus-plus">2</sub> and D<sub class="a-plus-plus">2</sub>. J Biol Chem 254:2914–2917</span>
</li>
<li>
<span class="authors">Schafer AI, Levine S, Handin RI (1980) Regulation of platelet arachidonic acid oxidation by cyclic AMP. Blood 56:853–858</span>
</li>
<li>
<span class="authors">Schaumann W, Juhran W, Dietmann K (1970) Antagonism of theophylline to circulatory effects of adenosine. Arzneim 20:372–377</span>
</li>
<li>
<span class="authors">Schillinger E, Prior G (1980) Prostaglandin I<sub class="a-plus-plus">2</sub> receptors in a particulate fraction of platelets of different species. Biochem Pharmacol 29:2297–2299</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-2952(80)90261-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Schneider WHG (1974) Regulation of energy metabolism in human platelets by cyclic AMP. In: Baldini MG, Ebbe S (eds) Platelets: production, function, transfusion and storage. Grune & Stratton, New York, pp 177–186</span>
</li>
<li>
<span class="authors">Schoepflin GS, Pickett W, Austen KF, Goetzl EJ (1977) Evaluation of the cyclic GMP concentration in human platelets by sodium ascorbate and 5-hydroxytryptamine. J Cyclic Nucleotide Res 3:355–356</span>
</li>
<li>
<span class="authors">Schoepflin GS, Goetzl EJ, Austen KF (1978) The predominant contribution of platelets to baseline and ascorbate-stimulated increments in cyclic GMP in human mononuclear leucocytes. Cell Immunol 35:330–339</span>
<a class="external" href="http://dx.doi.org/10.1016/0008-8749(78)90153-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Scott M, Reading HW, Loudon JB (1979) Studies of human blood platelets in affective disorders. Psychopharmacology (Berlin) 60:131–135</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00432283" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Shattil SJ, McDonough M, Turnbull J, Insel PA (1981) Characterization of alpha-adrenergic receptor in human platelets using <sup class="a-plus-plus">3</sup>H Clonidine. Mol Pharmacol 19:179–183</span>
</li>
<li>
<span class="authors">Shio H, Ramwell PW, Jessup SJ (1972) Prostaglandin E<sub class="a-plus-plus">2</sub>: effects on aggregation, shape change and cyclic AMP of rat platelets. Prostaglandins 1:29–36</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(72)90063-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Siegl AM, Smith JB, Silver MJ, Nicolaou KC, Ahern D (1979 a) Selective binding sites for (<sup class="a-plus-plus">3</sup>H) prostacyclin on platelets. J Clin Invest 63:215–220</span>
<a class="external" href="http://dx.doi.org/10.1172/JCI109292" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Siegl AM, Smith JB, Silver MJ (1979 b) Specific binding sites for prostaglandin D<sub class="a-plus-plus">2</sub> on human platelets. Biochem Biophys Res Commun 90:291–296</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(79)91623-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Sinha AK, Colman RW (1978) Prostaglandin E<sub class="a-plus-plus">1</sub> inhibits platelet aggregation by a pathway independent of adenosine 3′,5′-monophosphate. Science 200:202–203</span>
<a class="external" href="http://dx.doi.org/10.1126/science.204997" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Sinha AK, Colman RW (1980) Persistence of increased platelet cyclic AMP induced by prostaglandin E<sub class="a-plus-plus">1</sub> after removal of the hormone. Proc Natl Acad Sci USA 77:2946–2950</span>
<a class="external" href="http://dx.doi.org/10.1073/pnas.77.5.2946" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Sinha AK, Shattil SJ, Colman RW (1977) Cyclic AMP metabolism in cholesterol-rich platelets. J Biol Chem 252:3310–3314</span>
</li>
<li>
<span class="authors">Smith JB, Macfarlane DE (1974) Platelets. In: Ramwell PW (ed) The prostaglandins, vol 2. Plenum, New York, pp 293–343</span>
</li>
<li>
<span class="authors">Smith JB, Mills DCB (1971) Inhibition of adenosine 3′:5′-cyclic monophosphate phosphodiesterase. Biochem J 120:20 P</span>
</li>
<li>
<span class="authors">Smith JB, Silver MJ, Ingerman CM, Kocsis JJ (1974) Prostaglandin D<sub class="a-plus-plus">2</sub> inhibits the aggregation of the human platelets. Thromb Res 5:291–299</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(74)90168-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Smith JB, Ingerman CM, Silver MJ (1976) Formation of prostaglandin D<sub class="a-plus-plus">2</sub> during endoperoxide-induced platelet aggregation. Thromb Res 9:413–418</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(76)90141-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Smith JB, Ogletree ML, Lefer AM, Nicolaou KC (1978) Antibodies with antagonise the effect of prostacyclin. Nature 274:64–65</span>
<a class="external" href="http://dx.doi.org/10.1038/274064a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Song S-Y, Cheung WY (1971) Cyclic 3′5′-nucleotide phosphodiesterase. Properties of the enzyme of human blood platelets. Biochim Biophys Acta 242:593–605</span>
</li>
<li>
<span class="authors">Statland BE, Heagan BM, White JG (1969) Uptake of calcium by platelet relaxing factor. Nature 223:521–522</span>
<a class="external" href="http://dx.doi.org/10.1038/223521a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Steer ML, Wood A (1979) Regulation of human platelet adenylate cyclase by epinephrine, prostaglandin E<sub class="a-plus-plus">1</sub> and guanine nucleotides. J Biol Chem 254:10791–10797</span>
</li>
<li>
<span class="authors">Steer ML, Khorana J, Galgoci B (1979) Quantitation and characterization of human platelet alpha adrenergic receptors using (<sup class="a-plus-plus">3</sup>H) phentolamine Mol Pharmacol 16:719–728</span>
</li>
<li>
<span class="authors">Steer ML, MacIntyre DE, Levine L, Salzman EW (1980) Is prostacyclin a physiologically important circulating antiplatelet agent? Nature 283:194–195</span>
<a class="external" href="http://dx.doi.org/10.1038/283194a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Steiner M (1975) Endogenous phosphorylation of platelet membrane proteins. Arch Biochem Biophys 171:245–254</span>
<a class="external" href="http://dx.doi.org/10.1016/0003-9861(75)90029-6" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Steiner M (1978) 3′,5′-cyclic AMP binds to and promotes polymerization of platelet tubulin. Nature 272:834–835</span>
<a class="external" href="http://dx.doi.org/10.1038/272834a0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Stoff JB, Stemmerman M, Steer M, Salzman EW, Brown RS (1980) A defect in platelet aggregation in Bartter’s syndrome. Am J Med 68:171–180</span>
<a class="external" href="http://dx.doi.org/10.1016/0002-9343(80)90351-4" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Subbarao K, Rucinski B, Niewiarowski S (1977) Effect of dipyridamole on adenosine uptake by human platelets and ADP-induced platelet aggregation. Biochem Pharmacol 26:906–907</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-2952(77)90413-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Tateson JE, Moncada S, Vane JR (1977) Effects of prostacyclin (PGX) on cyclic AMP concentrations in human platelets. Prostaglandins 13:387–397</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(77)90019-3" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Taylor PM, Heppinstall S (1978) Cyclic nucleotide phosphodiesterase activity and the platelet release reaction. Thromb Haemost 39:550–555</span>
</li>
<li>
<span class="authors">Taylor RG, Lewis JC, Rudell LL, Biddulph DM (1979) Low density lipoprotein modulation of cAMP in avian thrombocytes. Thromb Res 14:799–804</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(79)90135-X" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Tsai BS, Lefkowitz RJ (1978) Agonist-specific effects of monovalent and divalent cations on adenylate cyclase-coupled alpha receptors in rabbit platelets. Mol Pharmacol 14:540–548</span>
</li>
<li>
<span class="authors">Tsai BS, Lefkowitz RJ (1979) Agonist-specific effects of guanine nucleotides on alpha adrenergic receptors in human platelets. Mol Pharmacol 16:61–68</span>
</li>
<li>
<span class="authors">Vainer H (1977) <sup class="a-plus-plus">14</sup>C-epinephrine interaction with platelet membrane binding sites. Cell Structure Function 2:267–280</span>
<a class="external" href="http://dx.doi.org/10.1247/csf.2.267" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Vainer H, Bussel A (1979) Decreased number of binding sites for [<sup class="a-plus-plus">14</sup>C]-epinephrine on human platelet membranes in chronic myeloid leukemia. IRCS Med Sci 7:47</span>
</li>
<li>
<span class="authors">Vane JR, Moncada S (1980) Prostacyclin. Blood cells and vessel walls: functional interactions. Ciba Found Symp 71:79–97</span>
</li>
<li>
<span class="authors">Vargaftig BB, Chignard M (1975) Substances that increase the cAMP content prevent platelet aggregation and the concurrent release of pharmacologically active substances evoked by arachidonic acid. Agents Actions 5:137–144</span>
<a class="external" href="http://dx.doi.org/10.1007/BF02027355" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Vargaftig BB, Chignard M, Benveniste J, Lefort J, Wal F (1981) Background and present status of research on platelet activating factor (PAF-acether). Ann NY Acad Sci USA 370:119–137</span>
<a class="external" href="http://dx.doi.org/10.1111/j.1749-6632.1981.tb29727.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Vigdahl RL, Marquis NR, Tavormina PA (1969) Platelet aggregation 2. Adenyl cyclase, prostaglandin E<sub class="a-plus-plus">1</sub> and calcium. Biochem Biophys Res Commun 37:409–415</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(69)90930-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Vigdahl RM, Mongin J Jr, Marquis NR (1971) Platelet aggregation 4. Platelet phosphodiesterase and its inhibition by vasodilators. Biochem Biophys Res Commun 42:1088–1094</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(71)90016-7" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Wang TY, Hussey CV, Garancis JC (1977) Effects of dibutyryl cyclic adenosine monophosphate and prostaglandin E<sub class="a-plus-plus">1</sub> on platelet aggregation and shape change. Am J Clin Pathol 67:362–367</span>
</li>
<li>
<span class="authors">Wang TY, Hussey CV, Sasse EA, Fabian JE (1978) Human platelet aggregation and cAMP system. cAMP level, adenyl cyclase, phosphodiesterase. Ann Clin Lab Sci 8:403–412</span>
</li>
<li>
<span class="authors">Wang Y-C, Pandey GN, Mendels J, Frazer A (1974 a) Effects of lithium on prostaglandin E<sub class="a-plus-plus">1</sub> stimulate adenylate cyclase of human platelets. Biochem Pharmacol 23:845–855</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-2952(74)90602-9" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Wang Y-C, Pandey GN, Mendels J, Frazer A (1974 b) Platelet adenylate cyclase response in depression: implications for a receptor defect. Psychopharmacologia 36:291–300</span>
<a class="external" href="http://dx.doi.org/10.1007/BF00422561" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Weisenberger H (1973) Cyclic AMP and platelet function. In: Gerlach E, Moser K, Deutsch E, Wilmanns W (eds) Erythrocytes, thrombocytes and leucocytes. Thieme, Stuttgart, pp 327–333</span>
</li>
<li>
<span class="authors">Weiss A, Baenziger NL, Atkinson JP (1978) Platelet release reaction and intracellular cyclic GMP. Blood 52:524–531</span>
</li>
<li>
<span class="authors">Westwick J, Webb H (1978) Selective antagonism of prostaglandin (PG) E<sub class="a-plus-plus">1</sub>, PGD<sub class="a-plus-plus">2</sub> and prostacyclin (PGI<sub class="a-plus-plus">2</sub>) on human and rabbit platelets by di-4-phloretin phosphate (DPP). Thromb Res 12:973–978</span>
<a class="external" href="http://dx.doi.org/10.1016/0049-3848(78)90053-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">White JG (1979) Current concepts of platelet structure. Am J Clin Pathol 71:363–378</span>
</li>
<li>
<span class="authors">White JG, Goldberg ND, Estensen RD, Haddox MK, Rao GHR (1973) Rapid increase in platelet cyclic 3′,5′-guanosine monophosphate (cGMP) levels in association with irreversible aggregation, deganulation and secretion. J Clin Invest 52:89 a</span>
</li>
<li>
<span class="authors">Whittle BJR, Moncada S, Vane JR (1978) Comparison of the effects of prostacyclin (PGI<sub class="a-plus-plus">2</sub>), prostaglandin E<sub class="a-plus-plus">1</sub> and D<sub class="a-plus-plus">2</sub> on platelet aggregation in different species. Prostaglandins 16:373–388</span>
<a class="external" href="http://dx.doi.org/10.1016/0090-6980(78)90216-2" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Wolfe SM, Shulman NR (1969) Adenyl cyclase activity in human platelets. Biochem Biophys Res Commun 35:265–272</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(69)90277-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Wolfe SM, Shulman NR (1970) Inhibition of platelet energy metabolism and release reaction by PGE<sub class="a-plus-plus">1</sub>, theophylline and cAMP. Biochem Biophys Res Commun 41:128–134</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(70)90478-X" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Wong PY-K, McGiff JC, Sun FF, Lee WH (1979) 6-Keto prostaglandin E<sub class="a-plus-plus">1</sub> inhibits the aggregation of human platelets. Eur J Pharmacol 60:245–248</span>
<a class="external" href="http://dx.doi.org/10.1016/0014-2999(79)90225-5" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Wong PY-K, Malik KU, Desiderio DM, McGiff JC, Sun FF (1980) Hepatic metabolism of prostacyclin (PGI<sub class="a-plus-plus">2</sub>) in the rabbit. Formation of a potent novel inhibitor of platelet aggregation. Biochem Biophys Res Commun 93:486–494</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(80)91103-1" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Yamazaki H, Motomiya T, Mashimo N, Asano T, Hidaka H (1978) Platelet aggregation and cyclic nucleotide phosphodiesterase activity in atherosclerotic patients. Thromb Haemost 39:158–166</span>
</li>
<li>
<span class="authors">Yu SK, Latour JG (1977) Potentiation by <em class="a-plus-plus">α</em> and inhibition by <em class="a-plus-plus">β</em> adrenergic stimulation of rat platelet aggregation: a comparative study with human and rabbit platelets. Thromb Haemost 37:413–422</span>
</li>
<li>
<span class="authors">Zappia GC, Steiner M, Ando Y, Baldini M (1976) Effect of chilling on platelet adenosine 3′:5′-monophosphate and adenylate cyclase activity. Transfusion 16:122–129</span>
<a class="external" href="http://dx.doi.org/10.1046/j.1537-2995.1976.16276155105.x" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Zieve PD, Greenough WB 3rd (1969) Adenyl cyclase in human platelets: activity and responsiveness. Biochem Biophys Res Commun 35:462–466</span>
<a class="external" href="http://dx.doi.org/10.1016/0006-291X(69)90368-4" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Zieve PD, Schmuckler M (1971) The effect of cyclic AMP on glycogenolysis and glycolysis in human platelets. Biochem Biophys Acta 252:280–284</span>
<a class="external" href="http://dx.doi.org/10.1016/0304-4165(71)90008-0" target="_blank" title="It opens in new window">CrossRef</a>
</li>
<li>
<span class="authors">Zucker MB (1980) The functioning of blood platelets. Sci Am 242:86–103</span>
<a class="external" href="http://dx.doi.org/10.1038/scientificamerican0680-86" target="_blank" title="It opens in new window">CrossRef</a>
</li>
</ol>
</div>
</div>
</div>
</div>
<div id="abstract-about" class="expander expander-open">
<div class="expander-title">
<div class="heading">
<button>
<h2>About this Chapter</h2>
</button>
</div>
</div>
<div class="expander-content">
<div class="expander-content-inner">
<div class="summary">
<dl>
<dt>Title</dt>
<dd id="abstract-about-title">The Role of Cyclic Nucleotides in Platelets</dd>
<dt>Book Title</dt>
<dd id="abstract-about-publication">
<a href="/book/10.1007/978-3-642-68393-0">Cyclic Nucleotides</a>
</dd>
<dt id="dt-abstract-about-book-subtitle">Book Subtitle</dt>
<dd id="abstract-about-book-subtitle">Part II: Physiology and Pharmacology</dd>
<dt id="dt-abstract-about-book-chapter-part-number">Book Part</dt>
<dd id="abstract-about-book-chapter-part-number">Section IV</dd>
<dt id="dt-abstract-about-book-chapter-page-ranges">Pages</dt>
<dd id="abstract-about-book-chapter-page-ranges">pp 723-761</dd>
<dt id="dt-abstract-about-book-chapter-copyright-year">Copyright</dt>
<dd id="abstract-about-book-chapter-copyright-year">1982</dd>
<dt>DOI</dt>
<dd id="abstract-about-book-chapter-doi" class="doi">10.1007/978-3-642-68393-0_20</dd>
<dt id="dt-abstract-about-book-print-isbn">Print ISBN</dt>
<dd id="abstract-about-book-print-isbn">978-3-642-68395-4</dd>
<dt id="dt-abstract-about-book-online-isbn">Online ISBN</dt>
<dd id="abstract-about-book-online-isbn">978-3-642-68393-0</dd>
<dt id="dt-abstract-about-book-series-title">Series Title</dt>
<dd id="abstract-about-book-series-title">
<a href="/bookseries/164">Handbook of Experimental Pharmacology</a>
</dd>
<dt id="dt-abstract-about-book-series-volume">Series Volume</dt>
<dd id="abstract-about-book-series-volume">58 / 2</dd>
<dt id="dt-abstract-about-book-series-subtitle">Series Subtitle</dt>
<dd id="abstract-about-book-series-subtitle">Continuation of Handbuch der experimentellen Pharmakologie</dd>
<dt id="dt-abstract-about-book-series-print-issn">Series ISSN</dt>
<dd id="abstract-about-book-series-print-issn">0171-2004</dd>
<dt id="dt-abstract-about-publisher">Publisher</dt>
<dd id="abstract-about-publisher">Springer Berlin Heidelberg</dd>
<dt id="dt-abstract-about-book-copyright-holder">Copyright Holder</dt>
<dd id="abstract-about-book-copyright-holder">Springer-Verlag Berlin Heidelberg</dd>
<dt>Additional Links</dt>
<dd id="abstract-about-additional-links">
<ul>
<li>
<a class="external" href="http://www.springer.com/978-3-642-68395-4" target="_blank" title="It opens in new window">About this Book</a>
</li>
</ul>
</dd>
</dl>
<dl>
<dt>Topics</dt>
<dd itemprop="genre">
<ul class="abstract-about-subject">
<li>
<a href="/search?facet-subject=%22Pharmacology%2FToxicology%22">Pharmacology/Toxicology</a>
</li>
<li>
<a href="/search?facet-subject=%22Pharmacy%22">Pharmacy</a>
</li>
</ul>
</dd>
<dt>Industry Sectors</dt>
<dd itemprop="genre">
<ul class="abstract-about-industrysectors">
<li>
<a title="/industry/health" href="/industry/health">Health & Hospitals</a>
</li>
<li>
<a title="/industry/biotech" href="/industry/biotech">Biotechnology</a>
</li>
<li>
<a title="/industry/pharma" href="/industry/pharma">Pharma</a>
</li>
</ul>
</dd>
<dt>eBook Packages</dt>
<dd itemprop="genre">
<ul class="abstract-about-ebook-packages">
<li>
<a href="/search?package=90011652">eBook Package english full Collection</a>
</li>
<li>
<a href="/search?package=11642">eBook Package english Biomedicine & Life Sciences</a>
</li>
</ul>
</dd>
</dl>
<dl>
<dt>Editors</dt>
<dd>
<ul class="editors">
<li itemprop="editor" itemscope="itemscope" itemtype="http://schema.org/Person">
<a class="person" href="/search?facet-author=%22Dr.+John+W.+Kebabian%22" itemprop="name">Dr. John W. Kebabian</a>
<sup title="Biochemical Neuropharmacology Unit, National Institutes of Health">(1)</sup>
</li>
<li itemprop="editor" itemscope="itemscope" itemtype="http://schema.org/Person">
<a class="person" href="/search?facet-author=%22Professor+Dr.+James+A.+Nathanson%22" itemprop="name">Professor Dr. James A. Nathanson</a>
<sup title="Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital">(2)</sup>
</li>
</ul>
</dd>
<dt>Editor Affiliations</dt>
<dd>
<ul class="editor-affiliations">
<li>
<span class="position">1.</span>
<span class="affiliation">
Biochemical Neuropharmacology Unit, National Institutes of Health
</span>
</li>
<li>
<span class="position">2.</span>
<span class="affiliation">
Neuropharmacology Research Laboratory, Departments of Neurology and Pharmacology, Harvard Medical School, Massachusetts General Hospital
</span>
</li>
</ul>
</dd>
<dt>Authors</dt>
<dd>
<ul class="authors">
<li itemprop="author" itemscope="itemscope" itemtype="http://schema.org/Person">
<a class="person" href="/search?facet-author=%22D.+C.+B.+Mills%22" itemprop="name">D. C. B. Mills</a>
</li>
</ul>
</dd>
</dl>
</div>
</div>
</div>
</div>
</div>
</div>
<div id="look-inside-interrupt" class="look-inside-interrupt">
<h3>Continue reading...</h3>
<div class="col-1">
<p>To view the rest of this content please follow the download PDF link above.</p>
</div>
</div>
</div>
<div id="web-trekk-abstract" doi="10.1007/978-3-642-68393-0_20" parentContentType="Book" contentType="Chapter" viewType="Abstract" publication="10.1007/978-3-642-68393-0 | Cyclic Nucleotides" embedFulltext="false"></div>
<div id="footer">
<hr/>
<div id="footer-verticals" class="section" role="navigation">
<span class="strapline">Over 8.5 million scientific documents at your fingertips</span>
<div class="flyout">
<button class="pillow-btn open-disciplines">
Browse by Discipline
<span class="caret"></span>
</button>
<ol class="disciplines">
<li>
<a href="/search?facet-discipline="Architecture+%26+Design"" title="follow this link to go to Architecture & Design">Architecture & Design</a>
</li>
<li>
<a href="/search?facet-discipline="Astronomy"" title="follow this link to go to Astronomy">Astronomy</a>
</li>
<li>
<a href="/search?facet-discipline="Biomedical+Sciences"" title="follow this link to go to Biomedical Sciences">Biomedical Sciences</a>
</li>
<li>
<a href="/search?facet-discipline="Business+%26+Management"" title="follow this link to go to Business & Management">Business & Management</a>
</li>
<li>
<a href="/search?facet-discipline="Chemistry"" title="follow this link to go to Chemistry">Chemistry</a>
</li>
<li>
<a href="/search?facet-discipline="Computer+Science"" title="follow this link to go to Computer Science">Computer Science</a>
</li>
<li>
<a href="/search?facet-discipline="Earth+Sciences+%26+Geography"" title="follow this link to go to Earth Sciences & Geography">Earth Sciences & Geography</a>
</li>
<li>
<a href="/search?facet-discipline="Economics"" title="follow this link to go to Economics">Economics</a>
</li>
<li>
<a href="/search?facet-discipline="Education+%26+Language"" title="follow this link to go to Education & Language">Education & Language</a>
</li>
<li>
<a href="/search?facet-discipline="Energy"" title="follow this link to go to Energy">Energy</a>
</li>
<li>
<a href="/search?facet-discipline="Engineering"" title="follow this link to go to Engineering">Engineering</a>
</li>
<li>
<a href="/search?facet-discipline="Environmental+Sciences"" title="follow this link to go to Environmental Sciences">Environmental Sciences</a>
</li>
<li>
<a href="/search?facet-discipline="Food+Science+%26+Nutrition"" title="follow this link to go to Food Science & Nutrition">Food Science & Nutrition</a>
</li>
<li>
<a href="/search?facet-discipline="Law"" title="follow this link to go to Law">Law</a>
</li>
<li>
<a href="/search?facet-discipline="Life+Sciences"" title="follow this link to go to Life Sciences">Life Sciences</a>
</li>
<li>
<a href="/search?facet-discipline="Materials"" title="follow this link to go to Materials">Materials</a>
</li>
<li>
<a href="/search?facet-discipline="Mathematics"" title="follow this link to go to Mathematics">Mathematics</a>
</li>
<li>
<a href="/search?facet-discipline="Medicine"" title="follow this link to go to Medicine">Medicine</a>
</li>
<li>
<a href="/search?facet-discipline="Philosophy"" title="follow this link to go to Philosophy">Philosophy</a>
</li>
<li>
<a href="/search?facet-discipline="Physics"" title="follow this link to go to Physics">Physics</a>
</li>
<li>
<a href="/search?facet-discipline="Psychology"" title="follow this link to go to Psychology">Psychology</a>
</li>
<li>
<a href="/search?facet-discipline="Public+Health"" title="follow this link to go to Public Health">Public Health</a>
</li>
<li>
<a href="/search?facet-discipline="Social+Sciences"" title="follow this link to go to Social Sciences">Social Sciences</a>
</li>
<li>
<a href="/search?facet-discipline="Statistics"" title="follow this link to go to Statistics">Statistics</a>
</li>
</ol>
</div>
</div>
<div id="footer-nav" class="section">
<div id="footer-nav-misc">
<div id="footer-our-content" class="block" role="navigation">
<h2>Our Content</h2>
<ul>
<li>
<a title="View Journals" href="/search?facet-content-type=%22Journal%22">Journals</a>
</li>
<li>
<a title="View Books" href="/search?facet-content-type=%22Book%22">Books</a>
</li>
<li>
<a title="View Book Series" href="/search?facet-content-type=%22BookSeries%22">Book Series</a>
</li>
<li>
<a title="View Protocols" href="/search?facet-content-type=%22Protocol%22">Protocols</a>
</li>
<li>
<a title="View Reference Works" href="/search?facet-content-type=%22ReferenceWork%22">Reference Works</a>
</li>
</ul>
</div>
<div id="footer-other-sites" class="block" role="navigation">
<h2>Other Sites</h2>
<ul>
<li>
<a title="Visit Springer.com" href="http://www.springer.com/">Springer.com</a>
</li>
<li>
<a title="Visit Springer Images" href="http://www.springerimages.com/">SpringerImages</a>
</li>
<li>
<a title="Visit Springer Protocols" href="http://www.springerprotocols.com/">SpringerProtocols</a>
</li>
<li>
<a title="Visit Springer Materials" href="http://www.springermaterials.com/">SpringerMaterials</a>
</li>
<li>
<a title="Visit Springer Reference" href="http://www.springerreference.com/">SpringerReference</a>
</li>
</ul>
</div>
<div class="block" role="navigation">
<h2>Help & Contacts</h2>
<ul>
<li>
<a class="contact-us-link" title="Contact us" href="/contactus">Contact Us</a>
</li>
<li>
<a class="feedback-community-link" title="Visit the Feedback Community" href="http://feedback.rd.springer.com/springer_rd">Feedback Community</a>
</li>
<li>
<a class="impressum-link" title="View Impressum" href="/impressum">Impressum</a>
</li>
</ul>
</div>
</div>
</div>
<div id="footer-legal" class="section" role="contentinfo">
<div id="mobile-nav">
<span class="pillow-btn open-legal" title="Show Legal Information">Legal</span>
</div>
<div id="legal" role="contentinfo">
<span id="footer-copyright">© Springer, Part of Springer Science+Business Media</span>
<a id="footer-privacy" title="View Terms and Conditions" href="/termsandconditions">Privacy Policy, Disclaimer, General Terms & Conditions</a>
<div id="diagnostic-info">
<span id="diagnostic-login-status">Not logged in</span>
<span class="diagnostic-business-partners">Orbis Cascade Alliance (3000165890)</span>
<span class="diagnostic-business-partners">PORTLAND STATE UNIV (8200420897)</span>
<span id="diagnostic-ip">131.252.130.248</span>
</div>
</div>
</div>
<div id="footer-branding" class="section">
<div class="block">
<span id="branding-logo">Springer for Research & Development</span>
</div>
</div>
<div id="google-analytics-account" style="display: none">UA-26408784-1</div>
</div>
<div id="doubleclick-ad" class="banner-advert">
<script type="text/javascript">if ( window.outerWidth || document.body.clientWidth > 1100 ) { googletag.cmd.push(function() { googletag.display('doubleclick-ad'); }); };</script>
</div>
</div>
<noscript>
<div id="jsnotice" class="prompt-bar">
<p>
JavaScript is currently disabled<span>, this site works much better if you enable JavaScript in your browser.</span>
</p>
</div>
</noscript>
<script src="/static/js/webtrekk/webtrekk_v3.js"></script>
<script type="text/javascript">
var webtrekkProperties = {
trackDomain : "springergmbh01.webtrekk.net",
trackId : "935649882378213",
pageType : "rd_springer_com.book.chapter_abstract"
,userDetails :{ 1: "3000165890;8200420897", 2: "Orbis Cascade Alliance;PORTLAND STATE UNIV" }
};
</script>
<noscript>
<div id="webtrekk">
<img src="http://springergmbh01.webtrekk.net/935649882378213/wt?p=315,rd_springer_com.book.chapter_abstract" height="1" width="1" alt=""/>
</div>
</noscript>
<script src="http://ajax.googleapis.com/ajax/libs/jquery/1.10.2/jquery.min.js"></script>
<script src="http://ajax.googleapis.com/ajax/libs/jqueryui/1.10.3/jquery-ui.min.js"></script>
<script src="http://code.jquery.com/jquery-migrate-1.2.1.js"></script>
<script src="/static/js/lib/crossmark.js"></script>
<script type="text/javascript">
var springerImagesProperties = {
apiUrl: 'http://api.springer.com/images/jsonp'
};
var vgWortProperties = {
vgWortDomain: 'springer.met.vgwort.de'
};
var inDevelopment = false;
</script>
<script src="/static/0.8657/js/all.js"></script>
<script type="text/x-mathjax-config" src="/static/0.8657/js/internal/mathJaxConfig.js"></script>
<script src="http://rd.springer.com/mathjax/v2.2/MathJax.js?config=TeX-AMS_HTML-full.js"></script>
<script src="/static/0.8657/js/internal/mathJaxHooks.js"></script>
<script type="text/javascript">
_gaq.push(['_setAccount', 'UA-26408784-1']);
_gaq.push (['_gat._anonymizeIp']);
_gaq.push(['_trackPageview']);
(function() {
var ga = document.createElement('script'); ga.type = 'text/javascript'; ga.async = true;
ga.src = ('https:' === document.location.protocol ? 'https://ssl' : 'http://www') + '.google-analytics.com/ga.js';
var s = document.getElementsByTagName('script')[0]; s.parentNode.insertBefore(ga, s);
})();
</script>
<div id="gimme-satisfaction"></div>
<script type="text/javascript">var _kiq = _kiq || [];</script>
<script type="text/javascript" src="//s3.amazonaws.com/ki.js/47412/9CC.js" async="true"></script>
<script type="text/javascript" charset="utf-8">
_kiq.push(['set', { 'BPID': '8200420897' }]);
</script>
</body>
</html>