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Effect of Eucommia ulmoides on Systolic Blood Pressure in the Spontaneous Hypertensive Rat : The American Journal of Chinese Medicine: Vol. 33, No. 02
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<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/"></link><meta name="dc.Title" content="Effect of Eucommia ulmoides on Systolic Blood Pressure in the Spontaneous Hypertensive Rat"></meta><meta name="dc.Creator" content="CynthiaLang"></meta><meta name="dc.Creator" content="ZhijunLiu"></meta><meta name="dc.Creator" content="H.Wayne Taylor"></meta><meta name="dc.Creator" content="David G.Baker"></meta><meta name="dc.Subject" content=" Eucommia ulmoides ; Du-Zhong; Hypertension; Rat; Medicinal Herb; Extract"></meta><meta name="dc.Description" content="Experiments were conducted to establish the safety and efficacy of Eucommia ulmoides (Du-Zhong) extract in the treatment of hypertension. Pilot experiments using rats demonstrated that E. ulmoides extract was safe to the saturation limits of the compound. The maximum tolerated dose (MTD) was 1200 mg/kg when administered by gastric gavage at a concentration of 1200 mg/ml. Also, rats given 200 mg/kg, 600 mg/kg or 1200 mg/kg doses of E. ulmoides extract daily for 28 days demonstrated no evidence of acute toxicity as determined by clinical appearance, histopathology and serum chemistry evaluation. Lastly, spontaneous hypertensive rats (SHRs) were administered E. ulmoides extract daily for 22 days. Systolic blood pressure (BP) was measured on treatment days 1, 8, 15 and 22 at 0, 1, 2 and 3 hours post-treatment. Beginning on day 8, E. ulmoides extract administered at the mid or high dosages lowered BP in male, but not female, rats. BP declined at a rate of approximately 10 mmHg per hour. The mid dosage of 600 m..."></meta><meta name="dc.Publisher" content=" World Scientific Publishing Company & Institute for Advanced Research in Asian Science and Medicine "></meta><meta name="dc.Date" scheme="WTN8601" content="2012-05-03"></meta><meta name="dc.Type" content="research-article"></meta><meta name="dc.Format" content="text/HTML"></meta><meta name="dc.Identifier" scheme="doi" content="10.1142/S0192415X05002795"></meta><meta name="dc.Source" content="http://dx.doi.org/10.1142/S0192415X05002795"></meta><meta name="dc.Language" content="en"></meta><meta name="dc.Coverage" content="world"></meta><meta name="keywords" content=" Eucommia ulmoides , Du-Zhong, Hypertension, Rat, Medicinal Herb, Extract"></meta>
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Cynthia Lang et al,
<i>Am. J. Chin. Med.</i>
<b><span itemprop='volume'>33</span></b>, 215 (<span itemprop="copyrightYear">2005</span>).
DOI: 10.1142/S0192415X05002795
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<div id="articleContent"><p class="fulltext"></p><!-- abstract content --><h1 class="arttitle">Effect of <i>Eucommia ulmoides</i> on Systolic Blood Pressure in the Spontaneous Hypertensive Rat</h1><div class="artAuthors">Cynthia Lang<div><li class="listGroup">Department of Pathobiological Sciences, School of Renewable Natural Resources, Louisiana State University, Baton Rouge, LA 70803, USA</li></div>Zhijun Liu<div><li class="listGroup">School of Veterinary Medicine and School of Renewable Natural Resources, Louisiana State University, Baton Rouge, LA 70803, USA</li></div>H. Wayne Taylor<div><li class="listGroup">Department of Pathobiological Sciences, School of Renewable Natural Resources, Louisiana State University, Baton Rouge, LA 70803, USA</li></div>David G. Baker<div><li class="listGroup">Correspondence to: Dr. David G. Baker, Division of Laboratory Animal Medicine, School of Veterinary Medicine, Louisiana State University, Baton Rouge, LA 70803, USA. Tel: (+01) 225-578-9643, Fax: (+01) 225-578-9649.</li><li class="listGroup">Department of Pathobiological Sciences, School of Renewable Natural Resources, Louisiana State University, Baton Rouge, LA 70803, USA</li></div></div><p class="fulltext"></p><div class="abstractSection"> <p class="first last">Experiments were conducted to establish the safety and efficacy of <i>Eucommia ulmoides</i> (Du-Zhong) extract in the treatment of hypertension. Pilot experiments using rats demonstrated that <i>E. ulmoides</i> extract was safe to the saturation limits of the compound. The maximum tolerated dose (MTD) was 1200 mg/kg when administered by gastric gavage at a concentration of 1200 mg/ml. Also, rats given 200 mg/kg, 600 mg/kg or 1200 mg/kg doses of <i>E. ulmoides</i> extract daily for 28 days demonstrated no evidence of acute toxicity as determined by clinical appearance, histopathology and serum chemistry evaluation. Lastly, spontaneous hypertensive rats (SHRs) were administered <i>E. ulmoides</i> extract daily for 22 days. Systolic blood pressure (BP) was measured on treatment days 1, 8, 15 and 22 at 0, 1, 2 and 3 hours post-treatment. Beginning on day 8, <i>E. ulmoides</i> extract administered at the mid or high dosages lowered BP in male, but not female, rats. BP declined at a rate of approximately 10 <span class="roman">mmHg</span> per hour. The mid dosage of 600 mg/kg was found to be the minimum effective dose. In conclusion, <i>E. ulmoides</i> extract was non-toxic and effective in reducing systolic BP in the SHR.</p> </div><!-- /abstract content --><div class="abstractKeywords"><b>Keywords: </b> <i>Eucommia ulmoides</i> ; Du-Zhong; Hypertension; Rat; Medicinal Herb; Extract</div><div></div><!-- fulltext content --><a name="citedBySection"><div class="citedBySection"><a name="citedBySection"></a><b>Cited by :</b><div class="citedByEntry"><a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(liu%2C+erwei)">Erwei<span class="NLM_x"> </span>Liu</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(han%2C+lifeng)">Lifeng<span class="NLM_x"> </span>Han</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(wang%2C+jialong)">Jialong<span class="NLM_x"> </span>Wang</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(he%2C+wei)">Wei<span class="NLM_x"> </span>He</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(shang%2C+haihua)">Haihua<span class="NLM_x"> </span>Shang</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(gao%2C+xiumei)">Xiumei<span class="NLM_x"> </span>Gao</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(wang%2C+tao)">Tao<span class="NLM_x"> </span>Wang</a>. (2012) <i>Eucommia ulmoides</i>
Bark Protects Against Renal Injury in Cadmium-Challenged Rats. <i><span class="NLM_source">Journal of Medicinal Food</span></i> <b>15</b>:3, 307-314. Online publication date: 1-Mar-2012.<!--noindex--><a class="ref" href="http://dx.doi.org/10.1089/jmf.2011.1756" target="_blank" title="Opens new window"> [ CrossRef ]</a><!--/noindex--></div><div class="citedByEntry"><a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(wang%2C+jia%5C-long)">Jia-Long<span class="NLM_x"> </span>Wang</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(liu%2C+er%5C-wei)">Er-Wei<span class="NLM_x"> </span>Liu</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(zhang%2C+yi)">Yi<span class="NLM_x"> </span>Zhang</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(wang%2C+tao)">Tao<span class="NLM_x"> </span>Wang</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(han%2C+li%5C-feng)">Li-feng<span class="NLM_x"> </span>Han</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(gao%2C+xiu%5C-mei)">Xiu-Mei<span class="NLM_x"> </span>Gao</a>. (2012) Validation of a HPLC-tandem MS/MS method for pharmacokinetics study of (+)-pinoresinol-di-β-d-glucopyranoside from Eucommia ulmoides Oliv extract in rats’ plasma. <i><span class="NLM_source">Journal of Ethnopharmacology</span></i> <b>139</b>:2, 337-342. Online publication date: 1-Jan-2012.<!--noindex--><a class="ref" href="http://dx.doi.org/10.1016/j.jep.2011.10.037" target="_blank" title="Opens new window"> [ CrossRef ]</a><!--/noindex--></div><div class="citedByEntry"><a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(tan+garcia%2C+joan)">Joan<span class="NLM_x"> </span>Tan Garcia</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(gonzaga%2C+florante)">Florante<span class="NLM_x"> </span>Gonzaga</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(tan%2C+delfin)">Delfin<span class="NLM_x"> </span>Tan</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(yaa+ng%2C+toon)">Toon<span class="NLM_x"> </span>Yaa Ng</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(ling+oei%2C+pau)">Pau<span class="NLM_x"> </span>Ling Oei</a>, <a class="entryAuthor" href="/action/doSearch?action=runSearch&type=advanced&result=true&prevSearch=%2Bauthorsfield%3A(chan%2C+cathryn+w.b.)">Cathryn W.B.<span class="NLM_x"> </span>Chan</a>. (2010) Use of a multibotanical (Nutrafem) for the relief of menopausal vasomotor symptoms. <i><span class="NLM_source">Menopause</span></i> <b>17</b>:2, 303-308. Online publication date: 1-Mar-2010.<!--noindex--><a class="ref" href="http://dx.doi.org/10.1097/gme.0b013e3181bf8e92" target="_blank" title="Opens new window"> [ CrossRef ]</a><!--/noindex--></div></div></a><!-- /fulltext content --></div>
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