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Synthesis of deoxyoligonucleotides on a polymer support - Journal of the American Chemical Society (ACS Publications)
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<link rel="schema.DC" href="http://purl.org/DC/elements/1.0/"></link><meta name="dc.Title" content="Synthesis of deoxyoligonucleotides on a polymer support"></meta><meta name="dc.Creator" content="M. D. Matteucci"></meta><meta name="dc.Creator" content="M. H. Caruthers"></meta><meta name="dc.Publisher" content="American Chemical Society"></meta><meta name="dc.Date" scheme="WTN8601" content="May 1, 2002"></meta><meta name="dc.Format" content="text/HTML"></meta><meta name="dc.Identifier" scheme="doi" content="10.1021/ja00401a041"></meta><meta name="dc.Language" content="EN"></meta><meta name="dc.Coverage" content="world"></meta>
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<a href="/action/clickThrough?id=317640&url=%2Fjournal%2Fjafcau&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">Journal of Agricultural and Food Chemistry</a>
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<a href="/action/clickThrough?id=317640&url=%2Floi%2Fjceaax&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">- I&EC Chemical & Engineering Data Series</a>
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<a href="/action/clickThrough?id=317640&url=%2Fjournal%2Fjceda8&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">Journal of Chemical Education</a>
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<a href="/action/clickThrough?id=317640&url=%2Floi%2Fjcisd8&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">- Journal of Chemical Documentation</a>
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<a href="/action/clickThrough?id=317640&url=%2Floi%2Fjcisd8&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">- Journal of Chemical Information and Computer Sciences</a>
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<a href="/action/clickThrough?id=317640&url=%2Fjournal%2Fjpccck&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">The Journal of Physical Chemistry C</a>
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<a href="/action/clickThrough?id=317640&url=%2Floi%2Fjpchax&loc=%2Fdoi%2Fabs%2F10.1021%2Fja00401a041&pubId=40065803">- The Journal of Physical Chemistry</a>
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<!-- abstract content --><h1 class="articleTitle">Synthesis of deoxyoligonucleotides on a polymer support</h1><!--AccessDenialMessagePlaceholder--><div id="links"><ul class="wide icons"><li class="icon-item pdf-high-res"><a title="Download the PDF Full Text" href="/doi/pdf/10.1021/ja00401a041"><div class="icon-32px"></div>PDF <span class="filesize">[998 KB]</span></a></li></ul><ul><li class="onPage"><a title="View the Abstract" href="/doi/abs/10.1021/ja00401a041"><span>First Page</span></a></li><li><a title="View Citing Articles" href="#citing"><span>Citing Articles</span></a></li><li class="rightQuickLinkLi icon-item chemworx-entry"><a title="Add to ACS ChemWorx" href="javascript:void(0)" onclick="ACSPubs.platinum.addCitation(['10.1021/ja00401a041']);"><div class="icon-32px"></div>
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</a></li></ul><!-- ppvBox placeholder --></div><div id="articleMeta"><div id="authors"><a id="authors" href="http://pubs.acs.org/action/doSearch?action=search&author=Matteucci%2C+M.+D.&qsSearchArea=author">M. D. Matteucci</a><span class="NLM_x"> </span><span class="NLM_x">, </span><a id="authors" href="http://pubs.acs.org/action/doSearch?action=search&author=Caruthers%2C+M.+H.&qsSearchArea=author">M. H. Caruthers</a><span class="NLM_x"> </span></div><div id="citation"><cite>J. Am. Chem. Soc.</cite>, <span class="citation_year">1981</span>, <span class="citation_volume">103</span> (11), pp 3185–3191</div><div id="doi"><strong>DOI: </strong>10.1021/ja00401a041</div><div id="pubDate">Publication Date: June 1981</div><a href="/servlet/linkout?suffix=s0&dbid=16384&doi=10.1021/ja00401a041&url=http%3A%2F%2Fwq5rp2ll8a.search.serialssolutions.com%3Fsid%3Dachs%26id%3Ddoi%3A10.1021%2Fja00401a041%26genre%3Darticle%26aulast%3DMatteucci%26date%3D1981%26atitle%3DSynthesis+of+deoxyoligonucleotides+on+a+polymer+support%26volume%3D103%26issue%3D11%26spage%3D3185%26epage%3D3191%26title%3DJournal+of+the+American+Chemical+Society" title="OpenURL PORTLAND STATE UNIV" onclick="newWindow(this.href);return false" class="sfxLink"><img src="/templates/jsp/_style2/_achs/images/sfxbutton.gif" alt="OpenURL PORTLAND STATE UNIV" /></a><div id="correspondence"></div><div id="articleIcons"><div><img src="/templates/jsp/_style2/_achs/images/icon-archive.gif" alt="ACS Legacy Archive"/></div></div></div><div class="archiveNote"><p><strong>Note: </strong>In lieu of an abstract, this is the article's first page.</p></div><div id="firstPage"><a href="#" onclick="showFull(this); return false;" title="Increase/Reduce Image Size"><span class="imgToggleMsg" style="width:611px">
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encouraged to perform a search in <a href="http://scifinder.cas.org">SciFinder</a>.
</p><p>This article has been cited by 43 ACS Journal articles (5 most recent appear below).</p><ul id="citedBy"><li><img src="/appl/literatum/publisher/achs/journals/content/joceah/2012/joceah.2012.77.issue-6/joceah.2012.77.issue-6/production/joceah.2012.77.issue-6.cover.jpg" alt="Cover Image" class="cover"/><h2><a href="/doi/abs/10.1021/jo202505h">Solution-Phase Synthesis of Branched DNA Hybrids Based on Dimer Phosphoramidites and Phenolic or Nucleosidic Cores</a></h2><div class="contributors">Helmut<span class="NLM_x"> </span>Griesser<span class="NLM_x">, </span>Mariyan<span class="NLM_x"> </span>Tolev<span class="NLM_x">, </span>Arunoday<span class="NLM_x"> </span>Singh<span class="NLM_x">, </span>Thomas<span class="NLM_x"> </span>Sabirov<span class="NLM_x">, </span>Claudia<span class="NLM_x"> </span>Gerlach<span class="NLM_x">, and </span>Clemens<span class="NLM_x"> </span>Richert<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">The Journal of Organic Chemistry</span></cite><strong>2012</strong> <em>77</em>
(6),
2703-2717</div><ul><li><h3>Solution-Phase Synthesis of Branched DNA Hybrids Based on Dimer Phosphoramidites and Phenolic or Nucleosidic Cores</h3><div class="contributors">Helmut<span class="NLM_x"> </span>Griesser<span class="NLM_x">, </span>Mariyan<span class="NLM_x"> </span>Tolev<span class="NLM_x">, </span>Arunoday<span class="NLM_x"> </span>Singh<span class="NLM_x">, </span>Thomas<span class="NLM_x"> </span>Sabirov<span class="NLM_x">, </span>Claudia<span class="NLM_x"> </span>Gerlach<span class="NLM_x">, and </span>Clemens<span class="NLM_x"> </span>Richert<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">The Journal of Organic Chemistry</span></cite><strong>2012</strong> <em>77</em>
(6),
2703-2717</div><p>Branched oligonucleotides with “CG zippers” as DNA arms assemble into materials from micromolar solutions. Their synthesis has been complicated by low yields in solid-phase syntheses. Here we present a solution-phase synthesis based on phosphoramidites of ...</p><div class="linkbar"><a href="/doi/abs/10.1021/jo202505h">Abstract</a>
| <a href="/doi/full/10.1021/jo202505h" title="View the Full Text HTML">Full Text HTML</a>
| <a target="_blank" title="Full-Text PDF" href="/doi/pdf/10.1021/jo202505h">PDF</a>
| <a title="Full-Text Enhanced PDF" target="_blank" href="/doi/pdfplus/10.1021/jo202505h">PDF w/ Links</a></div></li></ul></li><li><img src="/appl/literatum/publisher/achs/journals/content/jacsat/2011/jacsat.2011.133.issue-30/jacsat.2011.133.issue-30/production/jacsat.2011.133.issue-30.cover.jpg" alt="Cover Image" class="cover"/><h2><a href="/doi/abs/10.1021/ja201561z">Streamlined Process for the Chemical Synthesis of RNA Using 2′-<i>O</i>-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase</a></h2><div class="contributors">Douglas J.<span class="NLM_x"> </span>Dellinger<span class="NLM_x">, </span>Zoltán<span class="NLM_x"> </span>Timár<span class="NLM_x">, </span>Joel<span class="NLM_x"> </span>Myerson<span class="NLM_x">, </span>Agnieszka B.<span class="NLM_x"> </span>Sierzchala<span class="NLM_x">, </span>John<span class="NLM_x"> </span>Turner<span class="NLM_x">, </span>Fernando<span class="NLM_x"> </span>Ferreira<span class="NLM_x">, </span>Zoltán<span class="NLM_x"> </span>Kupihár<span class="NLM_x">, </span>Geraldine<span class="NLM_x"> </span>Dellinger<span class="NLM_x">, </span>Kenneth W.<span class="NLM_x"> </span>Hill<span class="NLM_x">, </span>James A.<span class="NLM_x"> </span>Powell<span class="NLM_x">, </span>Jeffrey R.<span class="NLM_x"> </span>Sampson<span class="NLM_x">, and </span>Marvin H.<span class="NLM_x"> </span>Caruthers<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">Journal of the American Chemical Society</span></cite><strong>2011</strong> <em>133</em>
(30),
11540-11556</div><ul><li><h3>Streamlined Process for the Chemical Synthesis of RNA Using 2′-<i>O</i>-Thionocarbamate-Protected Nucleoside Phosphoramidites in the Solid Phase</h3><div class="contributors">Douglas J.<span class="NLM_x"> </span>Dellinger<span class="NLM_x">, </span>Zoltán<span class="NLM_x"> </span>Timár<span class="NLM_x">, </span>Joel<span class="NLM_x"> </span>Myerson<span class="NLM_x">, </span>Agnieszka B.<span class="NLM_x"> </span>Sierzchala<span class="NLM_x">, </span>John<span class="NLM_x"> </span>Turner<span class="NLM_x">, </span>Fernando<span class="NLM_x"> </span>Ferreira<span class="NLM_x">, </span>Zoltán<span class="NLM_x"> </span>Kupihár<span class="NLM_x">, </span>Geraldine<span class="NLM_x"> </span>Dellinger<span class="NLM_x">, </span>Kenneth W.<span class="NLM_x"> </span>Hill<span class="NLM_x">, </span>James A.<span class="NLM_x"> </span>Powell<span class="NLM_x">, </span>Jeffrey R.<span class="NLM_x"> </span>Sampson<span class="NLM_x">, and </span>Marvin H.<span class="NLM_x"> </span>Caruthers<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">Journal of the American Chemical Society</span></cite><strong>2011</strong> <em>133</em>
(30),
11540-11556</div><p>An improved method for the chemical synthesis of RNA was developed utilizing a streamlined method for the preparation of phosphoramidite monomers and a single-step deprotection of the resulting oligoribonucleotide product using 1,2-diamines under ...</p><div class="linkbar"><a href="/doi/abs/10.1021/ja201561z">Abstract</a>
| <a href="/doi/full/10.1021/ja201561z" title="View the Full Text HTML">Full Text HTML</a>
| <a target="_blank" title="Full-Text PDF" href="/doi/pdf/10.1021/ja201561z">PDF</a>
| <a title="Full-Text Enhanced PDF" target="_blank" href="/doi/pdfplus/10.1021/ja201561z">PDF w/ Links</a></div></li></ul></li><li><img src="/appl/literatum/publisher/achs/journals/content/bcches/2011/bcches.2011.22.issue-4/bcches.2011.22.issue-4/production/bcches.2011.22.issue-4.cover.jpg" alt="Cover Image" class="cover"/><h2><a href="/doi/abs/10.1021/bc100444v">Targeting G-Quadruplex Structure in the Human c-Kit Promoter with Short PNA Sequences</a></h2><div class="contributors">Jussara<span class="NLM_x"> </span>Amato<span class="NLM_x">, </span>Bruno<span class="NLM_x"> </span>Pagano<span class="NLM_x">, </span>Nicola<span class="NLM_x"> </span>Borbone<span class="NLM_x">, </span>Giorgia<span class="NLM_x"> </span>Oliviero<span class="NLM_x">, </span>Valérie<span class="NLM_x"> </span>Gabelica<span class="NLM_x">, </span>Edwin De<span class="NLM_x"> </span>Pauw<span class="NLM_x">, </span>Stefano<span class="NLM_x"> </span>D’Errico<span class="NLM_x">, </span>Vincenzo<span class="NLM_x"> </span>Piccialli<span class="NLM_x">, </span>Michela<span class="NLM_x"> </span>Varra<span class="NLM_x">, </span>Concetta<span class="NLM_x"> </span>Giancola<span class="NLM_x">, </span>Gennaro<span class="NLM_x"> </span>Piccialli<span class="NLM_x">, and </span>Luciano<span class="NLM_x"> </span>Mayol<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">Bioconjugate Chemistry</span></cite><strong>2011</strong> <em>22</em>
(4),
654-663</div><ul><li><h3>Targeting G-Quadruplex Structure in the Human c-Kit Promoter with Short PNA Sequences</h3><div class="contributors">Jussara<span class="NLM_x"> </span>Amato<span class="NLM_x">, </span>Bruno<span class="NLM_x"> </span>Pagano<span class="NLM_x">, </span>Nicola<span class="NLM_x"> </span>Borbone<span class="NLM_x">, </span>Giorgia<span class="NLM_x"> </span>Oliviero<span class="NLM_x">, </span>Valérie<span class="NLM_x"> </span>Gabelica<span class="NLM_x">, </span>Edwin De<span class="NLM_x"> </span>Pauw<span class="NLM_x">, </span>Stefano<span class="NLM_x"> </span>D’Errico<span class="NLM_x">, </span>Vincenzo<span class="NLM_x"> </span>Piccialli<span class="NLM_x">, </span>Michela<span class="NLM_x"> </span>Varra<span class="NLM_x">, </span>Concetta<span class="NLM_x"> </span>Giancola<span class="NLM_x">, </span>Gennaro<span class="NLM_x"> </span>Piccialli<span class="NLM_x">, and </span>Luciano<span class="NLM_x"> </span>Mayol<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">Bioconjugate Chemistry</span></cite><strong>2011</strong> <em>22</em>
(4),
654-663</div><p>The cKit87up sequence d(5′AGGGAGGGCGCTGGGAGGAGGG3′) can form a unique G-quadruplex structure in the promoter region of the human c-kit protooncogene. It provides a peculiar platform for the design of selective quadruplex-binding agents, which could ...</p><div class="linkbar"><a href="/doi/abs/10.1021/bc100444v">Abstract</a>
| <a href="/doi/full/10.1021/bc100444v" title="View the Full Text HTML">Full Text HTML</a>
| <a target="_blank" title="Full-Text PDF" href="/doi/pdf/10.1021/bc100444v">PDF</a>
| <a title="Full-Text Enhanced PDF" target="_blank" href="/doi/pdfplus/10.1021/bc100444v">PDF w/ Links</a></div></li></ul></li><li><img src="/appl/literatum/publisher/achs/journals/content/bichaw/2010/bichaw.2010.49.issue-37/bichaw.2010.49.issue-37/production/bichaw.2010.49.issue-37.cover.jpg" alt="Cover Image" class="cover"/><h2><a href="/doi/abs/10.1021/bi100286n">Comparisons between Chemical Mapping and Binding to Isoenergetic Oligonucleotide Microarrays Reveal Unexpected Patterns of Binding to the <i>Bacillus subtilis</i> RNase P RNA Specificity Domain</a></h2><div class="contributors">Ruiting<span class="NLM_x"> </span>Liang<span class="NLM_x">, </span>Elzbieta<span class="NLM_x"> </span>Kierzek<span class="NLM_x">, </span>Ryszard<span class="NLM_x"> </span>Kierzek<span class="NLM_x">, and </span>Douglas H.<span class="NLM_x"> </span>Turner<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">Biochemistry</span></cite><strong>2010</strong> <em>49</em>
(37),
8155-8168</div><ul><li><h3>Comparisons between Chemical Mapping and Binding to Isoenergetic Oligonucleotide Microarrays Reveal Unexpected Patterns of Binding to the <i>Bacillus subtilis</i> RNase P RNA Specificity Domain<a class="ref" href="#fs1"></a></h3><div class="contributors">Ruiting<span class="NLM_x"> </span>Liang<span class="NLM_x">, </span>Elzbieta<span class="NLM_x"> </span>Kierzek<span class="NLM_x">, </span>Ryszard<span class="NLM_x"> </span>Kierzek<span class="NLM_x">, and </span>Douglas H.<span class="NLM_x"> </span>Turner<span class="NLM_x"> </span></div><div><cite><span class="NLM_source">Biochemistry</span></cite><strong>2010</strong> <em>49</em>
(37),
8155-8168</div><p>Microarrays with isoenergetic pentamer and hexamer 2′-O-methyl oligonucleotide probes with LNA (locked nucleic acid) and 2,6-diaminopurine substitutions were used to probe the binding sites on the RNase P RNA specificity domain of Bacillus subtilis. ...</p><div class="linkbar"><a href="/doi/abs/10.1021/bi100286n">Abstract</a>
| <a href="/doi/full/10.1021/bi100286n" title="View the Full Text HTML">Full Text HTML</a>
| <a target="_blank" title="Full-Text PDF" href="/doi/pdf/10.1021/bi100286n">PDF</a>
| <a title="Full-Text Enhanced PDF" target="_blank" href="/doi/pdfplus/10.1021/bi100286n">PDF w/ Links</a></div></li></ul></li><li><img src="/appl/literatum/publisher/achs/journals/covergifs/joceah/2009/joceah.2009.74.issue-24/cover.jpg" alt="Cover Image" class="cover"/><h2><a href="/doi/abs/10.1021/jo902254w">Highly Stereoselective Synthesis of α-<span class="smallcaps">d</span>-Mannopyranosyl Phosphosugars</a></h2><div class="contributors">David<span class="NLM_x"> </span>Crich<span class="NLM_x"> and </span>Sébastien<span class="NLM_x"> </span>Picard</div><div><cite><span class="NLM_source">The Journal of Organic Chemistry</span></cite><strong>2009</strong> <em>74</em>
(24),
9576-9579</div><ul><li><h3>Highly Stereoselective Synthesis of α-<span class="smallcaps">d</span>-Mannopyranosyl Phosphosugars</h3><div class="contributors">David<span class="NLM_x"> </span>Crich<span class="NLM_x"> and </span>Sébastien<span class="NLM_x"> </span>Picard</div><div><cite><span class="NLM_source">The Journal of Organic Chemistry</span></cite><strong>2009</strong> <em>74</em>
(24),
9576-9579</div><p>α-Mannopyranosyl phosphosugars are obtained in 61−90% yields from 4,6-O-benzylidene-protected mannosyl thioglycosides bearing ester functionality in the 3-O-position by coupling reactions with ammonium salts of phosphosugars on activation with 1-...</p><div class="linkbar"><a href="/doi/abs/10.1021/jo902254w">Abstract</a>
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