Hi Bryan, "The real obstacle, however, is not the creation or the manufacture of protective antibodies against pathogens, but the delivery of those antibodies or cells into the body. Currently the only way to deliver antibodies into the body is difficult and unreliable. One needs to isolate stem or immune cells (B and T cells) from each individual patient and then custom-tailor the receptors for their genetic backgrounds, a process that is far too expensive to implement on a mass scale." HUH???? (what year is this, anyway?) Customizeable individual (autologous) humoral & cytotoxic immunity-on-demand is not inordinately hard, I think. And it can possibly be achieved in computer-controlled microfluidics cells of the type that I surmise you're working on. The key, I'd guess, is to reproduce the natural temporal sequence of the various molecular environments that cause differentiation and then selection of a particular antigen-specific clonal line. The T would be harder than the B. Once your people know their stuff - and the literature is surely out there in the public domain - I'm very confident that it can be done. This stuff is not as hard as it looks to the uninitiated, i.e., those who are stuck in the last Century. This is the 21st Century. Also, I think it's hyped as really difficult so that the current status quo: rip-off the Government; rip-off the patient - is maintained. I'm out of the loop. Is there a huge (in terms of mindshare) Open Source Medicine Community out there? 12 attachments — Download all attachments (zipped for UTF-8 Filename encoding menu ) T cell - Wikipedia, the free encyclopedia.mht T cell - Wikipedia, the free encyclopedia.mht 380K Download Cytotoxic T cell - Wikipedia, the free encyclopedia.mht Cytotoxic T cell - Wikipedia, the free encyclopedia.mht 305K Download B cell - Wikipedia, the free encyclopedia.mht B cell - Wikipedia, the free encyclopedia.mht 610K Download Molecular aspects of T-cell differentiation.pdf Molecular aspects of T-cell differentiation.pdf 837K View Download Molecular orchestration of differentiation and function of regulatory T cells.pdf Molecular orchestration of differentiation and function of regulatory T cells.pdf 500K View Download The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.pdf The AKT–mTOR axis regulates de novo differentiation of CD4+Foxp3+ cells.pdf 3586K View Download In Vitro Differentiation of Adult Bone Marrow Progenitors into Antigen-Specific CD4 Helper T Cells Using Engineered Stromal Cells Expressing a Notch Ligand.pdf In Vitro Differentiation of Adult Bone Marrow Progenitors into Antigen-Specific CD4 Helper T Cells Using Engineered Stromal Cells Expressing a Notch Ligand.pdf 1102K View Download Repression of BCL-6 is required for the formation of human memory B cells in vitro.pdf Repression of BCL-6 is required for the formation of human memory B cells in vitro.pdf 2731K View Download Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor α chain expression on activated B cells.pdf Oct2 enhances antibody-secreting cell differentiation through regulation of IL-5 receptor α chain expression on activated B cells.pdf 2328K View Download Antigen-driven B cell differentiation in vivo.pdf Antigen-driven B cell differentiation in vivo.pdf 1322K View Download Antibody production by single, hapten-specific B lymphocytes- an antigen-driven cloning system free of filler or accessory cells.pdf Antibody production by single, hapten-specific B lymphocytes- an antigen-driven cloning system free of filler or accessory cells.pdf 1066K View Download Molecular mechanisms involved in receptor editing at the Ig heavy chain locus.pdf Molecular mechanisms involved in receptor editing at the Ig heavy chain locus.pdf 186K View Download