(concerned about health risks with sucrose?
Authors
Hecht SS. Kenney PM. Wang M. Trushin N. Agarwal S. Rao AV. Upadhyaya P.
Institution
University of Minnesota Cancer Center, Minneapolis 55455, USA.
hecht002@gold.tc.umn.edu
Title
Evaluation of butylated hydroxyanisole, myo-inositol, curcumin, esculetin,
resveratrol and lycopene as inhibitors of benzo[a]pyrene
plus 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung
tumorigenesis in A/J mice.
Source
Cancer Letters. 137(2):123-30, 1999 Apr 1.
Abstract
The potential activities of butylated hydroxyanisole (BHA), myo-inositol,
curcumin, esculetin, resveratrol and lycopene-enriched
tomato oleoresin (LTO) as chemopreventive agents against lung tumor induction
in A/J mice by the tobacco smoke carcinogens benzo[a]pyrene (BaP) and
4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were evaluated. Groups
of 20 A/J mice were treated weekly by gavage with a mixture of BaP and NNK (3
micromol each) for 8 weeks, then sacrificed 26 weeks after the first
carcinogen treatment. Mice treated with BHA (20 or 40 micromol) by gavage 2 h
before each dose of BaP and NNK had significantly reduced lung tumor
multiplicity. Treatment with BHA (20 or 40 micromol) by gavage weekly or with
dietary BHA (2000 ppm), curcumin (2000 ppm) or resveratrol
(500 ppm) from 1 week after carcinogen treatment until termination had no
effect on lung tumor multiplicity. Treatment with dietary myo-inositol
(30,000 ppm) or esculetin (2000 ppm) from 1 week after carcinogen treatment
until termination significantly reduced lung tumor multiplicity, with the
effect of myo-inositol being significantly greater than that of esculetin.
Treatment with dietary LTO (167, 1667 or 8333 ppm) from 1 week before
carcinogen treatment until termination had no effect on lung tumor
multiplicity. The results of this study demonstrate that BHA is an effective
inhibitor of BaP plus NNK-induced lung tumorigenesis in A/J mice when
administered during the period of carcinogen treatment and that, among the
compounds tested, myo-inositol is most effective after carcinogen treatment.