Authors
Fujiwara R. Komori T. Noda Y. Kuraoka T. Shibata H. Shizuya K. Miyahara
S. Ohmori M. Nomura J. Yokoyama MM.
Institution
Department of Immunology, Kurume University School of Medicine, Kurume,
Japan.
Title
Effects of a long-term inhalation of fragrances on the stress-induced
immunosuppression in mice.
Source
Neuroimmunomodulation. 5(6):318-22, 1998 Nov-Dec.
Abstract
The aim of this study was to determine the effects of the long-term
application of various fragrances on the suppression of immune response
induced by high-pressure stress in mice. The immune response was analyzed
based on plaque-forming cell (PFC) count, using mice sensitized with sheep
red blood cells. The decreased PFC involving thymic involution induced by
high-pressure stress in mice was restored by exposing the stressed mice to
tuberose, lemon, oakmoss and labdanum for 24 h following exposure to stress.
The decreased PFC and thymic involution from stress were restored by exposure
to lemon and oakmoss, but not to tuberose and labdanum when the mice were
exposed to those fragrances continuously for 3 weeks before the stress was
given, followed by exposure to the same fragrances for 24 h after the stress.
The decreased PFC and thymic involution from stress were restored by exposure
to lemon and labdanum for 24 h after the stress, but not to tuberose over 3
weeks before the stress was given. These data suggest that the
neuroimmunomodulatory effects of fragrances may be affected by tolerance
depending on the kinds of fragrances in the case of a long-term application.