All I've heard and read of uploading concentrates on taking an intact
brain and "reading it" to another substarate, a non-trivial task by any
measure. Instead of this approach, how about using a biological brain
as a scaffolding upon which to build an "uploaded" personna. After
extensive and successive augmentation, the grey matter will matter less
and less. The personna of such a being will begin to spred out of the skull
and into the hardware/software, so eventually the wet stuff will not
do anything that isn't done by the hardware/sotfware. Take that brain to
the recycle bin-- or what the hell, sell it! Maybe use it as the seed for
another version of you... What would you do with your brain if you no
longer needed it?
Uploading from this approach can for many of us can be considered to
already be underway.
Michael B.