sesame and blood pressur
Doug Skrecky (oberon@vcn.bc.ca)
Fri, 10 Apr 1998 02:01:47 -0700 (PDT)
Authors
Kita S. Matsumura Y. Morimoto S. Akimoto K. Furuya M. Oka N. Tanaka T.
Institution
Department of Pharmacology, Osaka University of Pharmaceutical Sciences,
Japan.
Title
Antihypertensive effect of sesamin. II. Protection against two-kidney,
one-clip renal hypertension and cardiovascular hypertrophy.
Source
Biological & Pharmaceutical Bulletin. 18(9):1283-5, 1995 Sep.
Abstract
We investigated the antihypertensive effect of sesamin, a lignan from
sesame oil, using two-kidney, one-clip
(2K,1C) renal hypertensive rats. After clipping the left renal artery,
animals were assigned to either a normal diet group (control group) or a
sesamin-containing (1% (w/w)) diet group (sesamin group). The sham-operated
rats (sham group) were fed a normal diet and tap water. The systolic blood
pressure of the control group increased progressively in comparison with the
sham group. This 2K,1C-induced hypertension was markedly reduced by feeding
the sesamin-containing diet. The systolic blood pressure after 4 weeks was
123.60 +/- 4.01 mmHg in the sham group, 187.43 +/- 5.69 mmHg in the control
group and 145.57 +/- 6.78 mmHg in the sesamin group, respectively. There were
significant increases in left ventricle plus septum weight-body weight ratio
in the control group compared with the sham group. This rise was also
significantly reduced in the sesamin group. When the thoracic aorta was
histochemically evaluated, the wall thickness and wall-to-lumen ratio in the
control group were significantly increased, compared with the sham group,
indicating that vascular hypertrophy had occurred in the control group. The
sesamin diet tended to ameliorate this vascular hypertrophy, although its
effect was not statistically significant. These findings suggest that sesamin
is useful as prophylactic treatment to combat the development of renal
hypertension and cardiac hypertrophy.