Re: Japanese Scientists Find Possible Alzheimer's Cure

From: Damien Broderick (d.broderick@english.unimelb.edu.au)
Date: Tue May 22 2001 - 21:09:42 MDT

>http://dailynews.yahoo.com/htx/nm/20010522/ts/health_japan_alzheimers_dc_2.
html

Here's a more technical abstract on the relevant substance, humanin:

http://dragon.prit.go.jp/en/Inter_Sympo/14th/lec12.html

< Using this system and a modified death trap method, we screened genes, by
transfecting a human expression cDNA library, that protected neuronal cells
from death by V642I APP. A clone, named Humanin (HN) cDNA, encoded a novel
24 amino acid polypeptide that prevented neuronal cell death induced by
V642I APP, KM595/596NL APP, M146L presenilin (PS)-1, and N141I PS-2,
without effect on neuronal cell death by Huntington's
disease/spinocerebellar ataxia - associated polyglutamine repeat Q79 or
familial amyotrophic lateral sclerosis-associated SOD1 mutants.>

I do like those modified death traps. (Actually a friend of mine used to
drive one.)

But personally, I'm waiting for the release of transhumanin. :)

Damien Broderick

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