Neurotoxicology 2000 Dec;21(6):1091-100
Association of silicofluoride treated water with elevated blood lead.
Masters RD, Coplan MJ, Hone BT, Dykes JE
Foundation for Neuroscience and Society, Dartmouth College,
Hanover, NH 03755-3547, USA. roger.d.masters@dartmouth.edu
[Medline record in process]
Previous epidemiological studies have associated silicofluoride-
treated community water with enhanced child blood lead parameters.
Chronic, low-level dosage of silicofluoride (SiF) has never been
adequately tested for health effects in humans. We report here
on a statistical study of 151,225 venous blood lead (VBL) tests
taken from children ages 0-6 inclusive, living in 105 communities
of populations from 15,000 to 75,000. The tests are part of a
sample collected by the New York State Department of Children's
Health, mostly from 1994-1998. Community fluoridation status
was determined from the CDC 1992 Fluoridation Census. Covariates
were assigned to each community using the 1990 U.S. Census.
Blood lead measures were divided into groups based on race and
age. Logistic regressions were carried out for each race/age
group, as well as above and below the median of 7 covariates to
test the relationship between known risk factors for lead uptake,
exposure to SiF-treated water, and VBL >10 microg/dL. RESULTS:
For every age/race group, there was a consistently significant
association of SiF treated community water and elevated blood
lead. Logistic regressions above and below the median value of
seven covariates show an effect of silicofluoride on blood lead
independent of those covariates. The highest likelihood of
children having VBL> 10 microg/dL occurs when they are both
exposed to SiF treated water and likely to be subject to another
risk factor known to be associated with high blood lead (e.g.,
old housing). Results are consistent with prior analyses of
surveys of children's blood lead in Massachusetts and NHANES
III. These data contradict the null hypothesis that there is
no difference between the toxic effects of SiF and sodium
fluoride, pointing to the need for chemical studies and
comprehensive animal testing of water treated with commercial
grade silicofluorides.
http://www.fluoridealert.org/neurotoxicology.htm
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