Ian Goddard <Ian@goddard.net> writes:
> On Mon, 13 Mar 2000 22:23:40 GMT, djmmm@my-deja.com wrote:
> >
> >Prozac does not work in a similar fashion as pcp.
>
> IAN: If both Prozac and PCP modify behavior by
> raising serotonin, I'd say they work in a similar
> way (which of course is not to say all things they
> do are similar). PCP, like Prozac, is believed to
> modify behavior by increasing serotonin levels.
The main effect of PCP is more complex, and deals with how it messes
up the dopaminergic activity of the ventral tegmental area and nucleus
accumbens through its NMDA-antagonist activity, something that
serotonin to my knowledge does not.
There are many kinds of serotonin receptors with very different
functions in the brain. That something increases serotonin levels
doesn't tell much, the important question is *where* it increases
serotonin levels. Also, Prozac is a specific reuptake inhibitor, not
an agonist or antagonist, so the effects would be very much different
from PCP even if they acted on the same systems.
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