Re: THC & Cognitive Function

From: Anders Sandberg (asa@nada.kth.se)
Date: Fri Dec 10 1999 - 04:13:50 MST


"Zeb Haradon" <zharadon@inconnect.com> writes:

> It's well known that the neural pathways for recognizing objects are
> different from those used in recognizing faces. This is illustrated by
> various disorders in which a person can recognize common household objects,
> but cannot recognize his father's face, or the opposite disorder where he
> can recognize faces but not objects.

The face recognition pathways are part of the general ventral object
recognition stream; recognition of everyday objects is based on data
from the lower levels of the stream just like face
recognition. Interestingly, tools and other objects closely associated
with actions seem to be independently recognised from the other
objects (likely with strong links to frontal areas), since they are
associated with various action-memories.
                                              -> normal objects
                                             /
low level visual processing -> higher levels --> faces (with limbic input)
                                             \
                                              -> tools (with frontal input)

> I suggest a line of research to discover if the receptor which THC
> binds to is responsible for mediation of facial recognition, and
> possibly usage of THC for treatment of facial aphasia (I don't know
> if that's the proper term for it).

Prosopagnosia. My guess is that THC affects the limbic system, and
this is the soruce of the over-detection of faces. Since most people
with prosopagnosia have damaged inferotemporal cortex, THC might not
help them much since the actual recognition system is out of order,
the increase in modulation won't change anything. Then again, they
might feel happier.

> It's been
> discovered recently that there are THC receptors in the eyes (which is why
> marijuana helps glaucoma patients), I'd bet that the receptors go all the
> way down the facial visual system.

There are cannabinoid receptors in a lot of places, the effects are
complicated. In the hippocampus it seems to mediate memory loss for
example (antagonists have nootropic effects).

-- 
-----------------------------------------------------------------------
Anders Sandberg                                      Towards Ascension!
asa@nada.kth.se                            http://www.nada.kth.se/~asa/
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