From: Robert J. Bradbury (bradbury@ilr.genebee.msu.su)
Date: Fri Nov 19 1999 - 10:40:00 MST
Well, I haven't managed to download this page yet,
>> http://www.wired.com/news/reuters/0,1349,32621,00.html
one of the trials of working in Russia.
But re:
> I heard Robert mention this at Extro 4 as being on his wish list.
The sequence has been "complete" since ~1998. I believe I
even found a rough copy on TIGR (www.tigr.org) at one point, but it
seems to be gone now. You can do Blast searches on the TIGR database
against D. radiodurans sequences so it is "kind of" finished.
There was some discussion of the work on the genome at the
TIGR genome conference in Sept. Its a strange organism
since it has 2-3 chromosomes (I keep seeing different numbers
quoted). Most bacteria only have 1 chromosome, though they
may have additional small plasmids.
It may be that they are having trouble finishing the complete
sequence, because it has been known for some time that there
are sequences of the D. radiodurans genome that are toxic to
E. coli (probably even some of those involved in radiation
tolerance). Those sequences are hard to clone and amplify
and may therefore be difficult to get placed into the sequence.
There is a lot of work still to be done on this organism, but
bit by bit we will begin to see how nature has implemented ECC
for DNA. One thing that seems apparent is *lots* of redundancy.
D. radiodurans is interesting from the perspective of astrobiology
and bioastronomy because it keeps being offered by proponents
of the Panspermia hypothesis (that the Earth was "seeded") as
an example of an organism that could cross interplanetary or
perhaps even interstellar space. I believe there was some
discussion of this in the PBS SETI series.
Robert
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