dibenzolymethane cures lymphoma/leukemia?

From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Tue Sep 28 1999 - 11:52:59 MDT


Citations: 1-2
<1>
Authors
  Huang MT. Lou YR. Xie JG. Ma W. Lu YP. Yen P. Zhu BT. Newmark H. Ho
  CT.
Institution
  Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State
  University of New Jersey, Piscataway 08854-8020, USA.
Title
  Effect of dietary curcumin and dibenzoylmethane on formation
  of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and
  lymphomas/leukemias in Sencar mice.
Source
  Carcinogenesis. 19(9):1697-700, 1998 Sep.
Local Messages
  Held at Gerstein, U of Toronto
Abstract
  Female Sencar mice (6 weeks old) were administered 1 mg of
  7,12-dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks.
  At 20 weeks after the first dose of DMBA, 68% of mice developed mammary
  tumors (the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias.
  Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting
  at 2 weeks before the first dose of DMBA and continuing until the end of the
  experiment, inhibited both the multiplicity and incidence of DMBA-induced
  mammary tumor by 97%. The incidence of lymphomas/leukemias was completely
  inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or
  no effect on the incidence of mammary tumors, and the incidence of
  lymphomas/leukemias was reduced by 53%.

<2>
Authors
  Singletary K. MacDonald C. Iovinelli M. Fisher C. Wallig M.
Institution
  Department of Food Science and Human Nutrition, University of Illinois,
  Urbana-Champaign, Urbana 61801, USA.
Title
  Effect of the beta-diketones diferuloylmethane (curcumin) and
  dibenzoylmethane on rat mammary DNA adducts and tumors
  induced by 7,12-dimethylbenz[a]anthracene.
Source
  Carcinogenesis. 19(6):1039-43, 1998 Jun.
Local Messages
  Held at Gerstein, U of Toronto
Abstract
  Curcumin is a beta-diketone constituent of the spice turmeric that possesses
  anticarcinogenic properties in several animal models. The present studies
  were conducted in order to identify beta-diketones structurally-related to
  curcumin that would be effective dietary blocking agents toward the
  initiation stage of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary
  carcinogenesis. Of the beta-diketone compounds initially screened for their
  capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7
  cells and a mutant subclone, curcumin (diferuloylmethane) and
  dibenzoylmethane were most effective. However, when added to
  semipurified diets fed to female rats, dibenzoylmethane
  (1%), but not curcumin (1%), was effective in inhibiting in vivo mammary
  DMBA-DNA adduct formation. This inhibitory effect on mammary adduct formation
  was associated with a significant increase in liver activities of glutathione
  S-transferase, QR and 7-ethoxyresorufin-O-deethylase activities. Female rats
  provided diets supplemented with dibenzoylmethane at 0.1,
  0.5 and 1.0% for 14 days prior to dosing with DMBA exhibited a significant
  decrease in mammary tumor development, compared with controls. However, tumor
  development for animals fed diets containing 1.0% curcumin was not different
  from that of controls. Therefore, dibenzoylmethane, and
  possibly other structurally-related beta-diketones, warrant examination as
  breast cancer chemopreventative blocking agents.



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