From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Tue Sep 28 1999 - 11:52:59 MDT
Citations: 1-2
<1>
Authors
Huang MT. Lou YR. Xie JG. Ma W. Lu YP. Yen P. Zhu BT. Newmark H. Ho
CT.
Institution
Laboratory for Cancer Research, College of Pharmacy, Rutgers, The State
University of New Jersey, Piscataway 08854-8020, USA.
Title
Effect of dietary curcumin and dibenzoylmethane on formation
of 7,12-dimethylbenz[a]anthracene-induced mammary tumors and
lymphomas/leukemias in Sencar mice.
Source
Carcinogenesis. 19(9):1697-700, 1998 Sep.
Local Messages
Held at Gerstein, U of Toronto
Abstract
Female Sencar mice (6 weeks old) were administered 1 mg of
7,12-dimethylbenz[a]anthracene (DMBA) by oral gavage once a week for 5 weeks.
At 20 weeks after the first dose of DMBA, 68% of mice developed mammary
tumors (the average 1.08 tumors per mouse) and 45% had lymphomas/leukemias.
Feeding 1% dibenzoylmethane (DBM) in AIN 76A diet, starting
at 2 weeks before the first dose of DMBA and continuing until the end of the
experiment, inhibited both the multiplicity and incidence of DMBA-induced
mammary tumor by 97%. The incidence of lymphomas/leukemias was completely
inhibited by 1% DBM diet. In contrast, feeding 2% curcumin diet had little or
no effect on the incidence of mammary tumors, and the incidence of
lymphomas/leukemias was reduced by 53%.
<2>
Authors
Singletary K. MacDonald C. Iovinelli M. Fisher C. Wallig M.
Institution
Department of Food Science and Human Nutrition, University of Illinois,
Urbana-Champaign, Urbana 61801, USA.
Title
Effect of the beta-diketones diferuloylmethane (curcumin) and
dibenzoylmethane on rat mammary DNA adducts and tumors
induced by 7,12-dimethylbenz[a]anthracene.
Source
Carcinogenesis. 19(6):1039-43, 1998 Jun.
Local Messages
Held at Gerstein, U of Toronto
Abstract
Curcumin is a beta-diketone constituent of the spice turmeric that possesses
anticarcinogenic properties in several animal models. The present studies
were conducted in order to identify beta-diketones structurally-related to
curcumin that would be effective dietary blocking agents toward the
initiation stage of 7,12-dimethylbenz[a]anthracene (DMBA)-induced rat mammary
carcinogenesis. Of the beta-diketone compounds initially screened for their
capacity to induce quinone-reductase (QR) activity in wild-type Hepa1c1c7
cells and a mutant subclone, curcumin (diferuloylmethane) and
dibenzoylmethane were most effective. However, when added to
semipurified diets fed to female rats, dibenzoylmethane
(1%), but not curcumin (1%), was effective in inhibiting in vivo mammary
DMBA-DNA adduct formation. This inhibitory effect on mammary adduct formation
was associated with a significant increase in liver activities of glutathione
S-transferase, QR and 7-ethoxyresorufin-O-deethylase activities. Female rats
provided diets supplemented with dibenzoylmethane at 0.1,
0.5 and 1.0% for 14 days prior to dosing with DMBA exhibited a significant
decrease in mammary tumor development, compared with controls. However, tumor
development for animals fed diets containing 1.0% curcumin was not different
from that of controls. Therefore, dibenzoylmethane, and
possibly other structurally-related beta-diketones, warrant examination as
breast cancer chemopreventative blocking agents.
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