From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Wed Sep 15 1999 - 13:19:31 MDT
High-dose biotin, an inducer of glucokinase expression, may synergize
with chromium picolinate to enable a definitive nutritional therapy for
type II diabetes
Medical Hypotheses (1999) 52(5): 401-406
M. F. McCarty
Summary Glucokinase (GK), expressed in hepatocyte and pancreatic B
cells, has a central regulatory role in glucose metabolism. Efficient GK
activity is required for normal glucose-stimulated insulin secretion,
postprandial hepatic glucose uptake, and the appropriate suppression of
hepatic glucose output and gluconeogenesis by elevated plasma glucose.
Hepatic GK activity is subnormal in diabetes, and GK may also be
decreased in the B cells of type II diabetics. In supraphysiological
concentrations, biotin promotes the transcription and translation of the
GK gene in hepatocytes; this effect appears to be mediated by activation
of soluble guanylate cyclase. More recent evidence indicates that biotin
likewise increases GK activity in islet cells. On the other hand,
high-dose biotin suppresses hepatocyte transcription of
phosphoenolpyruvate carboxykinase, the rate-limiting enzyme for
gluconeogenesis. Administration of high-dose biotin has improved glycemic
control in several diabetic animals models, and a recent Japanese
clinical study concludes that biotin (3 mg t.i.d. orally) can
substantially lower fasting glucose in type II diabetics, without
side-effects. The recently demonstrated utility of chromium picolinate in
type II diabetes appears to reflect improved peripheral insulin
sensitivity - a parameter which is unlikely to be directly influenced by
biotin. Thus, the joint administration of supranutritional doses of
biotin and chromium picolinate is likely to combat insulin resistance,
improve B-cell function, enhance postprandial glucose uptake by both
liver and skeletal muscle, and inhibit excessive hepatic glucose
production. Conceivably, this safe, convenient, nutritional regimen will
constitute a definitive therapy for many type II diabetics, and may
likewise be useful in the prevention and management of gestational
diabetes. Biotin should also aid glycemic control in type I patients.
Additional note by poster:
The dramatic effects of oral megadose biotin in diabetes have been
largely ignored by medical doctors, perhaps partly because some of the
research papers investigating this effect are not available in medline.
Also biotin is not a patentable drug and so there exists no motivation
for drug companies to promote this as a possible therapy.
Also note that supplemental magnesium (500 mg/day) has also been found
to reduce insulin requirements in type I diabetics. (Magnesium 1988 7:
117-122)
IMHO - I expect that biotin/chromium picolinate/magnesium
supplementation could eliminate the use of insulin by most type II
diabetics who try combination. Needless to say, don't expect either drug
companies selling insulin, or doctors to recommend this. If you want to
try this - you're on your own.
Also note that 16 mg/day biotin has been found to eliminate the need
for insulin in some type I diabetics. (Annals of the New York Academy of
Sciences June 24 1985 447: 389-392 - note that this citation is not
included in medline's database even though other papers from the same
issue are)
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