Are Poppy-Seed Cakes in Your Future

From: Matthew Gaylor (freematt@coil.com)
Date: Sun Jul 25 1999 - 08:48:09 MDT


Pubdate: Sat, 24 July 1999
Source: New Scientist (UK)
Copyright: New Scientist, RBI Limited 1999
Contact: letters@newscientist.com
Website: http://www.newscientist.com/

NO CAKE FOR YOU

As If Our Working Lives Weren't Fraught Enough Already...

YOU CAN FIND SCORES OF RECIPES for poppy-seed cake on the Internet. "Take
three-quarters of a cup of poppy seeds..." is how many of them will begin
before adding their favourite flavourings of lemon or orange, or even coffee.

Sounds tempting, but there are lots of people--many of them Americans--who
definitely won't want to indulge. That's because they know that if you eat
too many poppy seeds, a random drug test can show up a false positive for
morphine. And with drug testing in the workplace becoming ever more common,
that's just too embarrassing a risk to take, even if you might later be
able to talk your way out of it.

It sounds crazy that there are people who can't even eat a poppy-seed cake
or bagel without worrying about being pilloried as a user. But such is the
sensitivity of assays spun off from advances in molecular immunology that
drugs, or things that look like them, can be picked up at incredibly low
levels, days or weeks after they might have been taken. And the technology
is growing ever more sophisticated: today a urine sample, tomorrow a single
hair or the sweat from your palm will be enough.

The drug-testing business is booming in the US as more and more companies
are drawn into testing for a "drug-free workplace" by government
incentives. And the boom is now spreading to the UK (see "The prying game",
p 18). The big question is, does workplace drug testing actually achieve
anything?

Obviously with airline pilots, nuclear power plant operators, train drivers
or the police, there is a strong case to made for prohibiting the use of
all drugs, including alcohol. But in the average workplace, the situation
is far less clear. Drug testing, with a significant rate of false
positives, can create a climate of fear and loss of morale. And
drug-testing programmes are very expensive with the sample having to be
guarded as carefully as if it was part of a murder trial.

No contest: murder is harmful. But there is no clear evidence that people
who might occasionally smoke cannabis (the most common substance picked up
in testing given that alcohol is not usually considered a drug) are
generally less effective at work. And the last thing that any user of more
serious drugs needs is to suddenly lose his or her job and the one route
back to a normal life.

If a company needs a rational policy to increase productivity, rather than
advance moral outrage, it would surely be better off measuring productivity
directly and dealing with it, than measuring drug use just because
monoclonal antibodies have made it possible. Unfortunately, this is one
case where the lure of a highly sensitive new technology far outweighs the
value of its use. Let us not encourage workplace drug testing until we have
some idea of what--if any--overall good it can do society.

And let us eat poppy cake without losing any sleep.

~~~~~~~~~~~~~~~~~~~~~~~~~~

Pubdate: 24 July 1999
Source: New Scientist (UK)
Copyright: New Scientist, RBI Limited 1999
Contact: letters@newscientist.com
Website: http://www.newscientist.com/
Author: Matt Walker

THE PRYING GAME

LSD turns up in a woman's urine sample. If this was one of the
increasingly common workplace drugs tests, she'd probably be out of
job. But the woman is an 82-year-old intensive care patient who had
never taken LSD in her life. The only fun she had was taking ambroxol,
an over-the-counter medicine, which in addition to clearing mucus from
her lungs, caused the bogus test result.

Drugs tests are supposed to be a fast and accurate way for employers
to spot workers who are indulging in illicit thrills. But mounting
evidence suggests otherwise. Last year, after "finding LSD" in the
82-year-old woman's urine by serendipity, the same German researchers
uncovered 11 other false positives for the drug following urine tests
of a kind widely used in German drugs screening labs.

This is disturbing, since drug testing is a growth industry. According
to Lewis Maltby, director of the American Civil Liberties Union's
workplace rights office, 80 per cent of large US companies now test
their employees. Britain and Europe are catching on. The British
government's Forensic Science Service is coy about the number of UK
companies paying for its drug-testing service, but a spokeswoman said
that "demand is growing all the time". Last month, the Police
Superintendents' Association of England and Wales called for the law
to be changed so that random drugs tests can be carried out on all
police officers. Existing British laws such as The Transport and Works
Act of 1992 require some employers, such as providers of public
transport, to ensure their staff are drug-free on the job. As a result
these organisations perform random testing on employees--although less
extensively than counterparts in the US. However, doubts about the
validity of such tests remain.

Apart from the question marks over reliability, it is unclear whether
companies are harmed by drug use or even whether testing employees
actually helps business.

The most recent survey from the US National Institute on Drug Abuse
(NIDA) estimated that drug misuse by employees cost the country $14.2
billion in lost productivity in 1992, and their employers had to pay
twice as much in medical and compensation claims as for their
drug-free colleagues. But last year, researchers from Le Moyne
College's Institute of Industrial Relations in Syracuse, New York
state, examined the productivity of 63 high-tech firms and found that
companies testing workers were less productive than firms which
trusted their staff to be "clean". The reasons are unclear, but
testing is time-consuming and expensive, and can undermine the morale
and loyalty of staff. And some workers may even use drugs to boost
their performance, the researchers say.

Private Lives

Civil rights groups are quick to point out that the tests may identify
substances at insignificant doses because of recreational drug use
outside working hours and that such activity has no bearing on their
performance as employees.

Owen Tudor, policy officer of the British Trades Union Congress says:
"We're very concerned there is a creeping intrusion into people's
private lives." Such fears haven't deterred American society from
embracing the drugs testing culture, and tying itself in some legal
knots in the process. For example, in 1997, the Supreme Court ruled
that a Georgia law requiring political candidates to be drug tested
violated the Fourth Amendment's prohibition against unreasonable
searches. But in March last year, the same court upheld the legality
of compulsory random drugs tests for White House employees, presumably
to ensure the President is not served by drug-addled interns or worse,
senior advisers under the influence of narcotics.

But it's important to recognise the distinction between tests applied
to public workers and the tests carried out by private companies, says
Marilyn Huestis, acting chief of NIDA's drug metabolism programs.
Federal employees working in sensitive departments, the military, and
those covered by transport regulations routinely have their urine
tested for five key drugs--marijuana, cocaine, opiates, amphetamines
(including "speed") and PCP, the hallucinogen known as "angel dust".
Seventy-odd labs certified by the Substance Abuse Mental Health
Services Administration (SAMHSA), which has responsibility for federal
testing standards, perform the tests on samples kept under strictly
controlled conditions. Samples that come up positive are double
checked by a gas chromatograph mass spectrometer, the "gold standard"
test that identifies a substance's exact molecular structure. A doctor
then reviews the findings.

In contrast, some private employers work to lower standards. While
some do follow SAMHSA procedures and use federal laboratories, others
use poorly trained staff and commercial drugs testing kits to perform
on-site tests that are never confirmed, says Huestis. "You go from one
extreme to the other," she says. It all depends on the company and the
laws of the particular state. In the UK, the respected Forensic
Science Service does much of the testing for private companies. But a
number of smaller private testing services are also vying for business.

Earlier this year, Howard Taylor, director of laboratory services at
the US National Safety Alliance, a firm which runs drugs testing
programs for over 5000 companies, tested five commonly used commercial
kits for testing urine samples on site. All the manufacturers claimed
their tests were as accurate as any done in a lab. But that's not what
Taylor found. "The results indicated discrepancies between claims and
performance for all products," he says.

Four out of five kits recorded positives for tetrahydrocannabinol
(THC), the active ingredient in marijuana, at levels 25 per cent below
the SAMHSA's cut-off. Three kits recorded positives for morphine and
two kits registered PCP below similar cut-off levels (Journal of
Analytical Toxicology, vol 23, p 119).

Some employers may regard the SAMHSA cut-off levels to be as redundant
as workers with even the minutest amounts of an illegal drug in their
system. But what if someone tests positive without taking any illegal
substances?

It can happen--just by eating lunch. In 1997, Judith Bonicamp and Ida
Santana, chemists at Middle Tennessee State University, Murfreesboro,
showed that poppy seed dressings contain enough opiates to make you
test positive for morphine (Microchemical Journal, vol 58, p 73).

Sex is a more bizarre reason for failing a cocaine test. NIDA studies
have shown cocaine can be passed on in semen and absorbed through the
vagina, although the amounts are too small to register in most tests.
However, if drugs such as cocaine are placed on the lips or other
areas of the body, the risk is higher. It's quite likely that enough
could be transferred to another person through kissing or other oral
contact to produce a positive drugs test, says Dan Berkable, president
of the American Toxicology Institute in Las Vegas.

The problems associated with urine testing have sparked interest in
alternative techniques, mainly hair, sweat and saliva testing, says
Huestis. Proponents of hair testing argue that it is less invasive and
offers a much larger window of detection, as drugs stay in hair long
after they have been metabolised by the body.

But hair testing is controversial too, mainly because natural hair
colour can affect the amount of drug detected. Edward Cone, now
retired from NIDA, found that significantly more cocaine binds to the
very dark hair of male Afro-Americans than to hair of other groups.

SAMHSA's Drug Testing Advisory Board is looking at whether hair, sweat
or saliva tests could be appropriate for federal test programs. Each
may prove to be faster, cheaper and more sensitive than current
methods. But they come with their own problems, and the Board is
trying to draw up stringent guidelines to govern their use.

Regardless of the tests used, civil rights groups remain concerned.
"Of course we want employees to come to work sober," says Maltby of
the American Civil Liberties Union. "But private companies that
indiscriminately test are inevitably going to fire innocent people."

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