From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Mon Jun 14 1999 - 07:24:00 MDT
Citations: 1-3
<1>
Authors
Li Y. Sato T. Metori K. Koike K. Che QM. Takahashi S.
Institution
Biochemistry Laboratory, College of Pharmacy, Nihon University, Chiba, Japan.
Title
The promoting effects of geniposidic acid and aucubin in
Eucommia ulmoides Oliver leaves on collagen synthesis.
Source
Biological & Pharmaceutical Bulletin. 21(12):1306-10, 1998 Dec.
Abstract
We have reported that collagen synthesis was stimulated by the administration
of a hot water extract from the leaves of Eucommia ulmoides
OLIVER, Eucommiaceae (Du-Zhong leaves) in false aged model
rats. In this paper, we set out to examine the compounds in Du-Zhong leaves
that stimulated collagen synthesis in false aged model rats. In experiment 1,
a methanol extract of Du-Zhong leaves also stimulated collagen synthesis in
aged model rats. An acetone fraction was derived from the methanol extract by
silica gel chromatography in experiment 2. The acetone fraction mainly
contained iridoides mono-glycosides such as geniposidic acid and aucubin. The
administration of geniposidic acid or aucubin stimulated collagen synthesis
in aged model rats in experiments 3 and 4 (significance (p<0.05)). The
reported pharmacological effects of Du-Zhong leaves, including healing organs
and strengthening bone and muscle, are closely related to collagen
metabolism. It appears that geniposidic acid and aucubin are the actual
compounds in Du-Zhong which caused the effect in our experiments.
<2>
Authors
Metori K. Furutsu M. Takahashi S.
Institution
Department of Biochemistry, College of Pharmacy, Nihon University, Chiba,
Japan.
Title
The preventive effect of ginseng with du-zhong leaf on protein metabolism in
aging.
Source
Biological & Pharmaceutical Bulletin. 20(3):237-42, 1997 Mar.
Abstract
Stimulation of collagen synthesis prevents the aging process. We found such a
synergistic effect by using the leaves of Eucommia ulmoides
Oliver, Eucomiaceae (Du-Zhong leaf) and the roots of Panax ginseng C. A.
MEYER (Ginseng). The formula consists of amounts which exert no effect when
used individually. We tested several formula ratios of Ginseng and Du-Zhong
leaf, 1:1, 1:2, 1:3 and 1:4, and concluded that the last two formulas were
effective. However, we did not observe a significant difference between 1:3
and 1:4. Thus, it was demonstrated that the formula ratio of Ginseng to
Du-Zhong leaf of 1:3 was the most effective for the stimulation of collagen
synthesis and the prevention of decreased protein metabolism in aging.
<3>
Authors
Nakamura T. Nakazawa Y. Onizuka S. Satoh S. Chiba A. Sekihashi K. Miura
A. Yasugahira N. Sasaki YF.
Institution
Biotechnology Engineering Division, Hitachi Zosen Cor., Hiroshima, Japan.
Title
Antimutagenicity of Tochu tea (an aqueous extract of
Eucommia ulmoides leaves): 1. The clastogen-suppressing
effects of Tochu tea in CHO cells and mice.
Source
Mutation Research. 388(1):7-20, 1997 Jan 15.
Abstract
The suppressing effect of crude extracts of Tochu tea, an aqueous extract of
Eucommia ulmoides leaves and a popular beverage in Japan, on
the induction of chromosome aberrations in CHO cells and mice was studied.
When CHO cells were treated with Tochu tea crude extract after MMC treatment,
the frequency of chromosome aberrations was reduced. Out of 17 Tochu tea
components, 5 irridoids (geniposidic acid, geniposide, asperulosidic acid,
deacetyl asperulosidic acid, and asperuloside) and 3 phenols (pyrogallol,
protocatechuic acid, and p-trans-coumaric acid) were found to have
anticlastogenic activity. Since the anticlastogenic irridoids had an
alpha-unsaturated carbonyl group, this structure was considered to play an
important role in the anticlastogenicity. The anticlastogenic effect of Tochu
tea extracts was examined in mice using a micronucleus assay. When mice
received 1.0 ml 4% Tochu tea extract by oral gavage 6 h before
intraperitoneal injection of MMC, a decrease in the frequency of micronuclei
was observed. This decrease was not due to a delay in the maturation of
micronucleated reticulocytes.
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