From: CurtAdams@aol.com
Date: Sat Jun 05 1999 - 18:21:05 MDT
In a message dated 6/4/99 18:58:01, Paul Hughes wrote:
>Can somebody explain to me why nearly ALL studies determining Deprnyl's
effects on
>longevity have shown it to increase it as much as 60%, and this study
reveals the
>opposite? Can the genetic uniqueness of one species possibly have the exact
>opposite reaction to a chemical versus every other species studied?
Oh, yes. There was one case where somebody crossed two related butterfly
species that both had multiple color patterns. Turned out the gene that
turned *on* a pattern in one species turned it *off* in another. The
researchers were quite surprised.
It's not the usual pattern, though.
Another possibility is that the details of the genetic background may make a
difference. People have found conflicting results for longevity when you
splice in extra antioxidant genes in flies. Careful research showed it
varied with the flies you spliced it into - some flies benefitted from the
gene while other flies of the same species were hurt.
(I do have this reference handy - "FLP Recombinase-Mediated Induction of
Cu/Zn-Superoxide Dismutase Transgene Can Extend the Life Span of Adult
Drosophila Melanogaster Flies" Jingtao Sun and John Tower, Molecular
and Cellular Biology, Jan 1999. Sorry, no page number since my copy's a
preprint.)
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