From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Sun Dec 08 2002 - 20:42:59 MST
This is the 73'rd update of my fly longevity experiments. Average
temperature was 25.5 C during this run. Here mitochondrial
antioxidants/substrates are tested. I also recently found another source
for coconut juice, and with an eye to making (colorless) coconut juice a
standard addition I test out this lastest batch.
The control had a very poor survival, possibly because of viral
contamination. Acetyl-L-carnitine (ALC) by itself did nothing, and
inconsistent effects were obtained with lipoic acid by itself. However the
combination of ALC 125 mg & lipoic 25 mg yielded a more "normal" survival
curve. I've obtained large increases in survival before, but it has always
been when the control bottle showed poor results. I'm skeptical, but
none-the-less will try ALC, and lipoic acid again.
The negative result with coconut juice was a big surprise, as this
type of fruit juice has repeatedly exhibited a survival promoting effect
in the past. However the coconut juice used this time is from a different
source, and possibly heat treatment may have deactivated the juice. This
coconut juice is looked at again in the next run.
Run #73 Percent Survival on Day
supplement 6 15 24 36 43 48 53 59 66 71 78 83
______________________________________________________________
control 83 54 21 4 0 - - - - - - -
coconut juice 80 30 8 3 0 - - - - - - -
ALC 125 mg 90 45 5 3 0 - - - - - - -
ALC 125 mg + lipoic 25 mg 92 78 62 48 29 12 11 8 5 3 2 0
ALC 500 mg 78 56 22 0 - - - - - - - -
ALC 500 mg + lipoic 100 mg 77 40 20 0 - - - - - - - -
lipoic 25 mg 80 4 0 - - - - - - - - -
lipoic 100 mg 85 40 30 10 5 5 0 - - - - -
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