From: gts (gts@optexinc.com)
Date: Tue Oct 08 2002 - 21:29:19 MDT
Here is more research supporting my view that the information contained
in our genes is indispensable in the preservation of our personalities.
ABSTRACT
A multivariate analysis of 59 candidate genes in personality traits: the
temperament and character inventory
DE Comingsa, R Gade-Andavolua, N Gonzaleza, S Wua, D Muhlemana, H
Blakea, MB Manna, G Dietza, G Saucierb and JP MacMurrayc
Cloninger (Cloninger CR. Neurogenetic adaptive mechanisms in alcoholism.
Science 1987: 236: 410-416) proposed three basic personality dimensions
for temperament: novelty seeking, harm avoidance, and reward dependence.
He suggested that novelty seeking primarily utilized dopamine pathways,
harm avoidance utilized serotonin pathways, and reward dependence
utilized norepinephrine pathways. Subsequently, one additional
temperament dimension (persistence) and three character dimensions
(cooperativeness, self-directedness, and self-transcendence) were added
to form the temperament and character inventory (TCI). We have utilized
a previously described multivariate analysis technique (Comings DE,
Gade-Andavolu R, Gonzalez N et al. Comparison of the role of dopamine,
serotonin, and noradrenergic genes in ADHD, ODD and conduct disorder.
Multivariate regression analysis of 20 genes. Clin Genet 2000: 57:
178-196; Comings DD, Gade-Andavolu R, Gonzalez N et al. Multivariate
analysis of associations of 42 genes in ADHD, ODD and conduct disorder.
Clin Genet 2000: in press) to examine the relative role of 59 candidate
genes in the seven TCI traits and test the hypothesis that specific
personality traits were associated with specific genes. While there was
some tendency for this to be true, a more important trend was the
involvement of different ratios of functionally related groups of genes,
and of different genotypes of the same genes, for different traits.
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