From: Robert J. Bradbury (bradbury@aeiveos.com)
Date: Tue Sep 10 2002 - 13:01:22 MDT
On Wed, 11 Sep 2002, Christopher Whipple wrote:
> Unfortunately, I couldn't find the study as cited in the report.
> Needless to say, it's discouraging to see things like this in the media.
There are 2 Y2001 studies involving Jaenisch in PNAS. I don't know
if the article is citing a more recent, perhaps, in process publications.
Kevin Eggan, Hidenori Akutsu, Janet Loring, Laurie Jackson-Grusby, Martina Klemm, William M. Rideout, 3rd, Ryuzo Yanagimachi, and
Rudolf Jaenisch
Hybrid vigor, fetal overgrowth, and viability of mice derived by nuclear cloning and tetraploid embryo complementation
PNAS 2001 98: 6209-6214; published online before print as 10.1073/pnas.101118898
Abstract: http://www.pnas.org/cgi/content/abstract/98/11/6209?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Rudolf+Jaenisch&searchid=1031683786145_1867&stored_search=&FIRSTINDEX=08
Volker H. Haase, Jonathan N. Glickman, Merav Socolovsky, and Rudolf Jaenisch
Vascular tumors in livers with targeted inactivation of the von Hippel-Lindau tumor suppressor
PNAS 2001 98: 1583-1588.
Abstract: http://www.pnas.org/cgi/content/abstract/98/4/1583?maxtoshow=&HITS=10&hits=10&RESULTFORMAT=&author1=Rudolf+Jaenisch&searchid=1031683786145_1867&stored_search=&FIRSTINDEX=0¤8
I'll go on record here that the cloning of any animal from adult
cells is a very bad idea. Those cells have sustained damage
of uncategorized significance. Most humans are the product
of cells that happen to have survived damage inducing environments.
Unless you introduce a natural selection sieve to filter the damaged
programs -- reproductive cloning (as currently conducted) is a very
bad idea.
Another way to look at this is that you can *never* get a
perfect copy. Not with our current hardware. So you have
to decide whether you want an approximate copy or wait
until perfect copies are feasible.
Robert
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