From: Damien Broderick (d.broderick@english.unimelb.edu.au)
Date: Tue Jul 30 2002 - 21:20:15 MDT
New study here in Oz suggests that Clioquinol might indeed be a fix for
Alzheimer's, reducing amyloid plaques. Here's an old source on it:
http://www.ext.colostate.edu/pubs/columnha/ha0106.html
< The amyloid deposits in the Alzheimer's brain are held together in part
by copper and zinc bonds. We all need small quantities of copper and zinc
to live, so we do not want to completely remove these metals from our
bodies. But if we could break the bonds in the amyloid deposits, we might
be able to fight the disease. An old antibiotic called clioquinol seems to
be able to do exactly this. Mice that are given clioquinol seem to lose the
amyloid deposits. Clioquinol has been approved by the FDA as an antibiotic,
but was removed from the market because of side effects involving the loss
of Vitamin B-12. A clinical trial is under way to see if clioquinol,
perhaps supplemented with B-12, can be helpful in humans with Alzheimer's. >
Damien Broderick
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