Fascinating: hemispheric specificity of depression!?

From: Michael M. Butler (butler@comp-lib.org)
Date: Thu Apr 04 2002 - 16:25:44 MST


http://www.medscape.com/viewarticle/430189

Visual field stimulation of the less depressed hemisphere apparently was found
helpful. Bizarre, very interesting if true. Forward this to anyone who you
think could benefit from it. Fair use, this is important news, Copyright
retained by Menisses Communication Group, please don't sue me, I'm broke.

MMB

...

Report: Depression Research Supports Dual-Brain Theory

   from Mental Health Weekly

   Researchers have uncovered evidence that illnesses, such as depression, are
associated with one half
   of the brain and that by activating the brain's healthier other half, a
person's condition may improve. The
   report appears in this month's Neuropsychiatry, Neuropsychology, and
Behavioral Neurology.

   "If you activate the healthier hemisphere, you may help the person. If you
activate the hemisphere where
   the troubles were, you make it worse," Fredric Schiffer, M.D., an associate
attending psychiatrist at
   McLean Hospital, told MHW.

   According to Schiffer, who is working with researchers at other
institutions on this research, severely
   depressed patients' spirits were lifted when they received visual stimuli
primarily to the healthy left side
   of the brain, and their mood improved significantly when their left
hemispheres were treated with a more
   powerful form of stimulation, involving electromagnetic fields.

   In a healthy person, the two parts of the brain work together in harmony;
however, in people suffering with
   an illness like depression, one hemisphere may sabotage or dominate the
other.

   Schiffer said this latest report supports his earlier theory developed
several years ago, which found that
   each half of the healthy brain houses a separate emotional mind. At that
time, he found that he could
   elicit positive emotional responses from depressed patients by restricting
their visual stimuli to one
   hemisphere.

   He equipped his patients with goggles that restricted their visual stimuli
to the right field of vision. He
   found that the goggles directed stimuli mostly to the left hemisphere,
because signals from the right field
   of vision travel primarily to the opposite side of the brain.

   Schiffer's depressed patients reported feeling better when visual stimuli
was directed primarily to their
   left hemisphere, which suggested their right hemispheres were functioning
abnormally. To develop a
   stronger approach to stimulating the healthier left hemisphere of the
brain, Schiffer began working with
   Alvaro Pascual-Leone, MD, Ph.D., a researcher at Boston's Beth Israel
Deaconess Medical Center, who
   developed a method of stimulating the brain using electromagnetic fields,
called transcranial magnetic
   stimulation (TMS).

   Schiffer and Pascual-Leone suspected that the TMS method benefited only 50
percent of depressed
   patients. They suspected that those patients were the ones whose healthy
hemispheres were being
   stimulated. They embarked on an experiment to determine if those patients
could be identified in
   advance by Schiffer's goggle test.

   When they channeled visual stimuli primarily to the left side of 37
depressed patients for 45 seconds
   and then to their right side for the same time, they found that 20 patients
reported feeling better when
   stimuli were directed to the left side of the brain, suggesting it was the
healthier hemisphere. Fifteen
   patients felt worse, which suggested the right half of their brain was
healthier. The patients subsequently
   received a two-week course of TMS treatments only to the left hemisphere.

   The patients' depression levels were tested prior to wearing the goggles
and tested again two weeks
   after the last of a series of TMS treatments using a standard measure,
called the Hamilton Depression
   Rating Scale (HDRS).

   Under the HDRS measure, higher scores are associated with higher levels of
depression. The
   researchers found that the 20 patients who felt more improvement with the
left hemisphere visual
   stimulation experienced a median 42 percent reduction in HDRS. A
fifty-percent reduction is considered
   remission. The average reduction for the second group of 15 patients who
felt worse was only 11
   percent, which is considered below the failure mark.

   Schiffer said the study could be used to fortify current TMS procedures by
predicting which individuals
   with depression will most likely benefit. "In addition, this study bolsters
my dual-brain hypothesis," said
   Schiffer.

   Schiffer said he uses goggles with positive results in his clinical
practice and as an adjunct to
   psychotherapy. He said he intends to take his approach a step further by
using functional MRI to study
   how the brain changes with goggle use. Schiffer said the functional image
will help them determine if the
   goggle activates one hemisphere more than the other.

   Call for Applications Applicants Sought for Leadership Program

   The International Center for Health Leadership Development is accepting
applications for the Health
   Partners Fellows Class of 2002 to 2004. The Health Partners Fellowship is a
two-year leadership
   development program that seeks to prepare a diversity of leaders capable of
and committed to creating
   organizational collaborations between communities and academic institutions
to improve health.

   Five week-long seminars are held each year to strengthen collaborative
leadership skills. For more
   information visit www.uic.edu/sph/healthleaders or call (312) 355-1087. The
application deadline is May
   17, 4 p.m. (CST).

   Resources SAMHSA Offers Guide on Screening for MI

   The Substance Abuse and Mental Health Services Administration (SAMHSA) has
released Screening for
   Mental Illness in Nursing Facility Applicants: Understanding Federal
Requirements. The new report is
   intended to help state and local authorities and nursing facilities
understand their responsibilities for
   ensuring proper admission and treatment of individuals with mental illness
applying to and residing in
   nursing facilities.

   The report covers Preadmission Screening and Resident Review (PASRR) policy
and is based on a
   review and comparison of current law, regulations and state guidance. The
report is published by
   SAMHSA's Center for Mental Health Services (CMHS)and can be downloaded from
   www.mentalhealth.org/cmhs/ManagedCare/pubs.asp.

   Mental Health Weekly 12(11):5-6, 2002. © 2002 Manisses Communications
Group, Inc

-- 
                     butler a t comp - lib . o r g
I am not here to have an argument. I am here as part of a civilization.
                           Sometimes I forget.


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