From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Mon Mar 04 2002 - 11:31:57 MST
[Comment by poster:The experiment below compared a diet containing
coenzyme Q8, with a Q-less diet. Caenorhabditis can manufacture coenzyme
Q9 themselves, so the experiment is really comparing the effect of Q9
versus Q8 on nematode longevity. Metabolism of Q9 is known to produce
less oxygen derived free radicals than metabolism of Q8. The human
isoform is coenzyme Q10, which generates still less oxygen derived free
radicals. Rodent studies using added Q10, find that longevity is either
increased or it is unchanged. Like nematodes, rodents naturally produce
Q9. IMHO, research using Q11, or Q12 might yield some
interesting results.]
________________________________________________________________
Extension of Life-Span in Caenorhabditis Elegans by a Diet Lacking
Coenzyme Q
Science 295: 120-123 2002
Abstract: The isoprenylated benzoquinone coenzyme Q is a redox-active
lipid essential for electron transport in aerobic respiration. Here, we
show that withdrawal of coenzyme Q (Q) from the diet of wild-type
nematodes extends adult life-span by 60%. The longevity of clk-l, daf-2,
daf-12, and daf-16 mutants is also extended by a Q-less diet. These
results establish the importance of Q in life-span determination. The
findings suggest that Q and the daf-2 pathway intersect at the
mitochondria and imply that a concerted production coupled with enhanced
scavenging of reactive oxygen species contributes to the substantial
life-span extension.
This archive was generated by hypermail 2.1.5 : Sat Nov 02 2002 - 09:12:45 MST