RE: FW: Obesity in mice offers proof of cloning's unpredictability

From: Harvey Newstrom (mail@HarveyNewstrom.com)
Date: Sat Mar 02 2002 - 16:22:27 MST


Robert J. Bradbury wrote,
> Actually I think Harvey misses one of the main problems with cloning.
> The process doesn't get gene imprinting right.

I didn't miss this. There are many factors in DNA duplication and
expression that current cloning techniques do not handle properly.

Current cloning techniques:
- fail to address mitochondrial DNA
- fail to address telomeres at the end of DNA
- fail to address factors that control gene expression
- fail to address damage suppression and damage repair of DNA
- fail to address DNA selection, egg selection, sperm selection of
contraception
- fail to address sperm and egg cell factors (such as imprinting enzymes),
but use adult cells
- may damage DNA in the process

In short, cloning a person's DNA with today's techniques will not produce
the same result that their parents' conception did. Many DNA-related
factors of selection and expression are not reproduced. In the future, when
these various other factors are better known and better duplicated, we will
see clones that are better copies of the originals.

--
Harvey Newstrom, CISSP <www.HarveyNewstrom.com>
Principal Security Consultant <www.Newstaff.com>


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