Re: glycation and ageing

From: Technotranscendence (neptune@mars.superlink.net)
Date: Sat Dec 23 2000 - 10:19:15 MST


On Friday, December 22, 2000 11:34 PM mez mez@mezziah.org wrote:
> Just to be clear - Carnosine inhibits glycation processes, reducing the
> amount of glycation that takes place. ALT-711 seems to break down
existing
> AGE's (Advanced Glycation Endproducts) in the body, restoring useful
> function.
>
> Carnosine seems potentially useful as a prophylactic, but I haven't seen
> any evidence that use late in life can restore function, which is what
> ALT-711 is being evaluated for.

Actually, in the January 2001 issue of _Life Extension_, two studies are
cited (p30) where carnosine seems to not only inhibit glycation but to
reverse it. If this is so, then it is more than a prophylactic.

Also, it's available over the counter right now and some toxicity studies
have already been done. The literature on it is much larger, I suspect,
than that on ALT-711, and it seems to be extremely safe.

I'm not dismissing ALT-711, just pointing out that some of what it does is
done by another, more readily available chemical. (If ALT-711 becomes
widely available, I'd certainly think about taking it.:) What would be
interesting to do would be to combine the two to see if there are any
synergistic effects.

Cheers!

Daniel Ust
http://uweb.superlink.net/neptune/

My "Rand the Libertarian," published in the current issue of _The Thought_,
is now up viewable on the web at:
http://uweb.superlink.net/neptune/RandLib.html



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