myo-inositol best at inhibiting cancer progression

From: Doug Skrecky (oberon@vcn.bc.ca)
Date: Tue Oct 03 2000 - 15:06:27 MDT


Title
  Evaluation of butylated
  hydroxyanisole, myo-inositol, curcumin, esculetin,
  resveratrol and lycopene as inhibitors of benzo[a]pyrene plus
  4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone-induced lung tumorigenesis in
  A/J mice.
Source
  Cancer Letters. 137(2):123-30, 1999 Apr 1.
Abstract
  The potential activities of butylated
  hydroxyanisole (BHA), myo-inositol, curcumin, esculetin,
  resveratrol and lycopene-enriched tomato oleoresin (LTO) as chemopreventive
  agents against lung tumor induction in A/J mice by the tobacco smoke
  carcinogens benzo[a]pyrene (BaP) and
  4-(methyl-nitrosamino)-1-(3-pyridyl)-1-butanone (NNK) were evaluated. Groups
  of 20 A/J mice were treated weekly by gavage with a mixture of BaP and NNK (3
  micromol each) for 8 weeks, then sacrificed 26 weeks after the first
  carcinogen treatment. Mice treated with BHA (20 or 40 micromol) by gavage 2 h
  before each dose of BaP and NNK had significantly reduced lung tumor
  multiplicity. Treatment with BHA (20 or 40 micromol) by gavage weekly or with
  dietary BHA (2000 ppm), curcumin (2000 ppm) or resveratrol (500 ppm) from 1
  week after carcinogen treatment until termination had no effect on lung tumor
  multiplicity. Treatment with dietary myo-inositol (30,000 ppm) or esculetin
  (2000 ppm) from 1 week after carcinogen treatment until termination
  significantly reduced lung tumor multiplicity, with the effect of
  myo-inositol being significantly greater than that of esculetin. Treatment
  with dietary LTO (167, 1667 or 8333 ppm) from 1 week before carcinogen
  treatment until termination had no effect on lung tumor multiplicity. The
  results of this study demonstrate that BHA is an effective inhibitor of BaP
  plus NNK-induced lung tumorigenesis in A/J mice when administered during the
  period of carcinogen treatment and that, among the compounds tested,
  myo-inositol is most effective after carcinogen treatment.



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