From: Dehede011@aol.com
Date: Fri Apr 07 2000 - 06:43:08 MDT
In a message dated 4/6/00 9:25:38 PM Pacific Daylight Time, klemencc@sgi.net
writes:
<< My inference based on the DNA polymerase alpha story that it should be
possible to prevent replicative senescence and compromised DNA repair
appears to have been confirmed beyond all reasonable expectations by Mike
West's findings. West claims to have totally conquered the cellular aging
clock by using just two naturally occurring molecular triggers that can
restore the youthful phenotype to any one of four entirely different types
of senescent cell (endothelial cells, astrocytes, chondrocytes, and
fibroblasts). (17) Finally, the possible significance of elongation factor
one has been delightfully demonstrated by a paper of Shepard et al. In which
flies made transgenic for EF-1 so as to avoid or postpone its down
regulation with age were shown to have mean life spans equivalent to the
maximum life spans of control flies. (18) However, this experiment is not
yet definitive and awaits rigorous verification.
>>
Don
That is really interesting. Do you have any predictions for when we can
expect a treatment to help us? Is there anything we can do now as
individuals?
Ron Harrison
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