From: Ian Goddard (Ian@goddard.net)
Date: Sun Mar 12 2000 - 21:40:54 MST
From: Ian@Goddard.net (Ian Goddard)
Newsgroups: alt.support.depression.medication
Subject: Re: Prozac & Violence - New Study
Date: Mon, 13 Mar 2000 04:08:05 GMT
Organization: Question Authority
On Mon, 13 Mar 2000 22:23:40 GMT, djmmm@my-deja.com wrote:
>
>Prozac does not work in a similar fashion as pcp.
IAN: If both Prozac and PCP modify behavior by
raising serotonin, I'd say they work in a similar
way (which of course is not to say all things they
do are similar). PCP, like Prozac, is believed to
modify behavior by increasing serotonin levels.
The journal Pharmacology, Biochemistry, and
Behavior (1984;21(3):401-8) states:
"From these results, PCP-induced stereotyped
behaviors are related to an increased serotonergic
neuronal activity due to 5-HT releasing action
and/or inhibitory action of 5-HT uptake-by this drug."
For those who may not know, 5-HT is serotonin. About
the degree to which PCP raises serotonin, or 5-HT,
the journal Neuroreport (1998;9(13):2985-8) states:
"We here report for the first time that
systemically administered PCP (5 mg/kg, s.c.)
increases extracellular 5-HT levels in the rat
medial prefrontal cortex (to 322%) and dorsal
hippocampus (to 233%)."
>PCP interacts with acetylcholene and the opiate system and is a nmda
>antagonist....it dose not block the reuptake of serotonin....
IAN: Yes, PCP is an NMDA antagonist, however, as
we see in the cited study, behavior modification
is linked to PCP's action on 5-HT. Several months
ago I contacted Lance Kreplick, M.D., <LKJK@aol.com>
who had written a report posted to the web about PCP.
I asked if PCP is an SSRI. He said: "Yes it is an SSRI."
Corroborating Dr. Kreplick is a study published in
Neuroscience Letters (2000;280(1):53-6), which states:
"Phencyclidine (PCP) is known to be an inhibitor of
serotonin (5-HT) uptake and to increase serotonergic activity."
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