TCD

[Geoff Crawford]

TCID means "Tissue Culture Infectious Dose" and is usually measured at the
50% point, ie the dilution of viral sample that produces CPE in 50% of the
replicates.  Thus you will also see it expressed as TCID50.

There is some statistical number crunching involved to arrive at the 50% end
point.  This was described in a paper written by Reed & Muench in the 1930s.

Regards,


--
Dr Geoff Crawford
Access Academix
89 Dellfield Drive
Templestowe VIC 3106
Australia

Phone      +61 3 981 272 80
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Email        access_academix at optusnet.com.au


Ruth B Hamilton <ruthh at zoo.cam.ac.uk> wrote in message
news:Pine.GSO.3.95.990923162959.27976J-100000 at parasite...
> I have been reading some fairly old virology papers which have measured
viral
> titres in log(10)TCD (I have also seen TCID). So far my searches of
textbooks,
> journals and websites haven't been able to define what this means.  Any
> explanation would be very helpful.
> Ruth
>
>
>
>