defective interfering genome

[brett]

>Dear virologist,
>Does every virus have defective interfering genome?
>Is this genome responsible to the attenuation of polio virus?
>Thank you
>
>Dori Ugiyadi

No naturally arising DI has ever been characterized for a flavivirus (also a
(+) RNA), although one can get subgenomic replicons by designing them. 


Brett Lindenbach
    
Program in Immunology                              
Washington University - St Louis                  
brett at borcim.wustl.edu                             

"I own my own pet virus. I get to pet and name her." - Cobain