Opinions on the CPE of Polio

[Wade]

I have been doing some paper research lately on picorna(esp. polio) 
viruses and have found that an explanation for the extensive CPE 
generated by multiplying polioviruses has yet to be explained.  Many 
suggestions exist, but I would like to see what others have to say as far 
as information or opinions on how the host cell is destroyed so rapidly.  
Post here or write the above address.
Thanks everyone