Student seeks research reports on Ebola/Marburg

[Bob Horton]

Jessica Jeffcote <jj at aardvark.apana.org.au> wrote:

> I am trying also to find the report on the 'investigation' into the
> possibility of aerosolization of the Ebola Virus (Tested by Jaax
> et al on primates by spraying concentrated droplets down the
> monkeys' throats). I've found plenty of comments about this
> but can't find the report itself.

Jessica;

This is probably the report you are looking for. If you want to read the 
whole thing, you'll probably have to get it from a university or medical 
library.

: Johnson E. Jaax N. White J. Jahrling P. Lethal experimental
: infections of rhesus monkeys by aerosolized Ebola virus.
: International Journal of Experimental Pathology. 76(4):227-36,1995 
:
: Abstract
:  The potential of aerogenic infection by Ebola virus was
:  established by using a head-only exposure aerosol system.
:  Virus-containing droplets of 0.8-1.2 microns were generated and
:  administered into the respiratory tract of rhesus monkeys via
:  inhalation. Inhalation of viral doses as low as 400 
:  plaque-forming units of virus caused a rapidly fatal disease in
:  4-5 days. The illness was clinically identical to that reported
:  for parenteral virus inoculation, except for the occurrence of
:  subcutaneous and venipuncture site bleeding and serosanguineous
:  nasal discharge. Immunocytochemistry revealed cell-associated
:  Ebola virus antigens present in airway epithelium, alveolar
:  pneumocytes, and macrophages in the lung and pulmonary lymph
:  nodes; extracellular antigen was present on mucosal surfaces of
:  the nose, oropharynx and airways. Aggregates of characteristic
:  filamentous virus were present within type I pneumocytes,
:  macrophages, and air spaces of the lung by electron microscopy.
:  Demonstration of fatal aerosol transmission of this virus in
:  monkeys reinforces the importance of taking appropriate
:  precautions to prevent its potential aerosol transmission to
:  humans.

---
Robert M. Horton
http://134.84.47.3                                       Have a :) day

"Scotty, try flushing the radioactive waste into the ventilation 
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