BSE versus Creutzveld-Jacobs-syndrome

[bhjelle at unm.edu]

In article <Pine.SOL.3.91.960401081356.18501C-100000 at ursa.cus.cam.ac.uk>,
Tim Fitzmaurice  <tjf11 at cus.cam.ac.uk> wrote:
>On 29 Mar 1996 bhjelle at unm.edu wrote:
>> co.uk/bse/tse.htm.#immunity). BSE can be transmitted into
>> transgenic mice bearing human PrP and produces human PrPSc.
>
>Excuse me could you cite this paper, the only work of this kind that I 
>have seen had transgenic mice infected with BSE, but those with were 
>positive solely for Human PrP did not develop, and those which where human 
>+ve/mouse +ve only developed mouse PrPsc....indicating a cattle to human
>species barrier in the experiment but no cattle to mouse barrier.
>
The paper to which I refer is in Nature 1995 vol 378
pages 761-2 (with commentary in the same issue page 759).
They claim to have produced human PrP Sc in heterozygous
mouse/human PrP transgenics. Obviously, this is not the
same as human/human homozygotes. The bovine protein may
have induced murine PrP Sc which then induced human PrP
Sc. Has the human/human homozygote transgenic work been
published? Even if negative this would be very helpful
information.

Brian