Viral DNA insertion into host genome.

[John Brunstein]

It's my understanding that while the site of AAV integration is in a cDNA 
(one of Ventner's ESTs, I believe) I do not think its function is known.  
I certainly have not heard anything with respect to a correlation between 
B19 integration and Alzheimers, and I suspect if there were data to 
suggest this there would be somewhat less interest in using AAV as a 
vector.. very few people want a genetic treatment if it's going to cause 
Alzheimers! :-)

On 22 Sep 1995, Don Haut wrote:

> In article <DFA9xD.4AE at freenet.carleton.ca>, aq224 at FreeNet.Carleton.CA
> (Dan Mcleod) wrote:
> 
> > Most interesting.  Was there any discussion w.r.t. mutation in chromosome
> > 19 in Alzheimers patients DNA and AAV integration.
> > Thanx
> > Dan McLeod
> > LCDC, Canada
> > 
> Not that we discussed, but I will read through the abstract book to see. 
> Unfortunately I could not make the meeting ($$$$$).  I am not familiar
> with the chromosome mutations in Alzheimers patients.  Do you have a ref??
> 
> Don
> 
> Don Haut 
> Molecular Microbiology and Immunology
> University of Missouri-Columbia
> C601591 at showme.missouri.edu
> 314-882-3171
> 
>