Viral DNA insertion into host genome.

[Dan Mcleod]

Most interesting.  Was there any discussion w.r.t. mutation in chromosome
19 in Alzheimers patients DNA and AAV integration.
Thanx
Dan McLeod
LCDC, Canada



Don Haut (c601591 at mizzou1.missouri.edu) writes:
> In article <199509141718.NAA15530 at hobbes.kzoo.edu>, ogston at HOBBES.KZOO.EDU
> (Walter Ogston) wrote:
> 
>> > In article <Pine.A32.3.91.950909123618.24020C-100000 at red.weeg.uiowa.edu>,
>> > volm timothy gerard <tvolm at blue.weeg.uiowa.edu> wrote:
> ...snip!!...
>> How do we explain the difference between a retrovirus and AAV, then?
>> (homework problem). 
> 
> As it turns out, I just came from a meeting where we discussed some of the
> new things that came out of the International Parvovirus Meeting which was
> held last week.  AAV integrates into an area of human Chromosome 19; from
> what is know it always integrates somewhere withing about a 1KB area which
> contains two specific sequences, but it does not always integrate at
> exacty the same place within that 1KB area.  Also, when we are thinking
> about the above "homework" we should remember, that AAV is not an
> autonomous virus, it requires Adenovirus proteins in order to replicate.
> 
> Don
> 
> Don Haut 
> Molecular Microbiology and Immunology
> University of Missouri-Columbia
> C601591 at showme.missouri.edu
> 314-882-3171


--
Dan McLeod, Ottawa, Ontario, Canada
e-mail dmcleod at hpb.hwc.ca  or aq224 at freenet.carleton.ca