CMV Latency

Catherine Patterson cpatterson at WATSON.PRINCETON.EDU
Tue Nov 28 10:47:34 EST 1995


mattw at sfsu.edu (MATTHEW FRANCIS WETTLAUFER) says this about CMV:

'The virus establishes latency in monocytes, endothelial cells,
smooth muscle cells, and some CD8+.  It is not yet known which cells act
as principle reservoir for the viral genome, nor is it known whether
latency is a true latency or a low level chronic production of virus
restricted by immune mediation (hence reactivation due to immunesuppression).'

Should we be more (or less) precise in what we say about CMV latency?

I don't know how many herpes virologists or latency experts subscribe to
this group, but I think it would be interesting to find out how everyone
feels about CMV latency.  Generally, I think it is accepted that the
monocytes are a long term resevoir and may harbor latent virus.  How do you
view this?





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