Flu question

[BIE034 at news.salford.ac.uk]

I was recently reading a book on protein structure and was intrigued by the 
influenza haemaglutinin protein. The book remarked that on the lowering 
of the pH whilst inside the endocytotic vesicle the viral protein undergoes a 
considerable structural change to fuse the viral membrane to that of the 
vesicle. The book was several years old but I would assume that such a change 
would be an ideal target for drug interactions and so should have a large 
body of associated research. Could anyone tell me if there has been any 
progress in determining the mechanism by which the change occurs? If so I 
would appreciate any pertinent references which they may know!

		I thank everyone for their help
		Simon.